Symptom Assessment in Adult Patients With Erosive GERD (Gastroesophageal Reflux Disease) or enGERD (Endoscopic-negative GERD) After Treatment With Pantoprazole (BY1023/M3-343)

NCT ID: NCT00336219

Last Updated: 2012-05-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

628 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-08-31

Study Completion Date

2007-04-30

Brief Summary

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The aim of this study is to compare investigator and patient-assessed gastroesophageal reflux disease symptoms in patients with erosive GERD or endoscopic-negative GERD (enGERD). An endoscopy will be performed at study start and study end. During the study, the patients will complete a patient-orientated, self-assessed reflux questionnaire (ReQuest™ questionnaire). The study duration consists of a baseline period (8 days) and treatment period (28 days). Pantoprazole (tablet) will be administered once daily at one dose level. The study will provide further data on safety and tolerability of pantoprazole.

Detailed Description

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Conditions

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GERD

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Pantoprazole 40 mg

Group Type ACTIVE_COMPARATOR

Pantoprazole

Intervention Type DRUG

Symptom Assessment after treatment with Pantoprozole 40 mg

Interventions

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Pantoprazole

Symptom Assessment after treatment with Pantoprozole 40 mg

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Written informed consent
* Outpatients
* History of GERD-related symptoms for at least 6 months prior to study inclusion
* Endoscopically confirmed erosive GERD or non-erosive GERD

Exclusion Criteria

* Acute peptic ulcer and/or ulcer complications
* PPIs during last 7 days prior to study start
* Systemic glucocorticoids or non-steroidal anti-inflammatory drugs including COX-2 inhibitors during the last 28 days prior to study start; except regular intake of acetylsalicylic acid up to a daily dose of 163 mg/day
* Intake of PPIs in combination with antibiotics for eradication of H. pylori
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Takeda

INDUSTRY

Sponsor Role lead

Responsible Party

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Nycomed

Principal Investigators

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Gerald Holtmann, Prof.

Role: PRINCIPAL_INVESTIGATOR

Department of Gastroenterology, Hepatology and General Medicine, Royal Adelaide Hospital, North Terrace, Adelaide, Australia

Locations

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Altana Pharma/Nycomed

Bondi Junction, , Australia

Site Status

Altana Pharma/Nycomed

Box Hill, Victoria, , Australia

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Altana Pharma/Nycomed

New South Wales, , Australia

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Altana Pharma/Nycomed

South Australia, , Australia

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Altana Pharma/Nycomed

Feldbach, , Austria

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Altana Pharma/Nycomed

Graz, , Austria

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Altana Pharma/Nycomed

Stockerau, , Austria

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Altana Pharma/Nycomed

Vienna, , Austria

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Altana Pharma/Nycomed

Wiener Neustadt, , Austria

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Altana Pharma/Nycomed

Amberg, , Germany

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Altana Pharma/Nycomed

Aschersleben, , Germany

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Altana Pharma/Nycomed

Berlin, , Germany

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Altana Pharma/Nycomed

Berlin, , Germany

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Altana Pharma/Nycomed

Berlin, , Germany

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Altana Pharma/Nycomed

Cologne, , Germany

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Altana Pharma/Nycomed

Cologne, , Germany

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Altana Pharma/Nycomed

Freising, , Germany

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Altana Pharma/Nycomed

Germersheim, , Germany

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Altana Pharma/Nycomed

Grünstadt, , Germany

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Altana Pharma/Nycomed

Jülich, , Germany

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Altana Pharma/Nycomed

Köthen, , Germany

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Altana Pharma/Nycomed

Künzing, , Germany

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Altana Pharma/Nycomed

Landsberg, , Germany

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Altana Pharma/Nycomed

Langen, , Germany

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Altana Pharma/Nycomed

Leipzig, , Germany

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Altana Pharma/Nycomed

Ludwigshafen, , Germany

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Altana Pharma/Nycomed

Lüneburg, , Germany

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Altana Pharma/Nycomed

Mönchengladbach, , Germany

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Altana Pharma/Nycomed

München, , Germany

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Altana Pharma/Nycomed

Potsdam-Babelsberg, , Germany

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Altana Pharma/Nycomed

Reinfeld, , Germany

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Altana Pharma/Nycomed

Saarbrücken, , Germany

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Altana Pharma/Nycomed

Budapest, , Hungary

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Altana Pharma/Nycomed

Győr, , Hungary

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Altana Pharma/Nycomed

Hatvan, , Hungary

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Altana Pharma/Nycomed

Kaposvár, , Hungary

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Altana Pharma/Nycomed

Kistarcsa, , Hungary

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Altana Pharma/Nycomed

Miskolc, , Hungary

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Altana Pharma/Nycomed

Szentes, , Hungary

Site Status

Altana Pharma/Nycomed

Vác, , Hungary

Site Status

Countries

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Australia Austria Germany Hungary

Other Identifiers

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BY1023/M3-343

Identifier Type: -

Identifier Source: org_study_id

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