Study of Human Insulin Inhalation Powder in Patients With Type 2 Diabetes

NCT ID: NCT00325364

Last Updated: 2019-09-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

415 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-04-30

Study Completion Date

2008-05-31

Brief Summary

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This is a phase 3, open-label, randomized study to evaluate the safety and efficacy of the Lilly/Alkermes inhaled insulin system compared to injected pre-meal insulin in non-smoking patients with type 2 diabetes. Patients will be treated for 24 months with a 2-month follow-up period.

Detailed Description

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Conditions

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Diabetes Mellitus, Type 2

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Group Type EXPERIMENTAL

Human Insulin Inhalation Powder

Intervention Type DRUG

patient specific dose, inhaled, before meals, 24 months

2

Group Type ACTIVE_COMPARATOR

Injectable insulin

Intervention Type DRUG

patient specific dose, injectable, before meals, 24 months

Interventions

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Human Insulin Inhalation Powder

patient specific dose, inhaled, before meals, 24 months

Intervention Type DRUG

Injectable insulin

patient specific dose, injectable, before meals, 24 months

Intervention Type DRUG

Other Intervention Names

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LY041001

Eligibility Criteria

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Inclusion Criteria

* Type 2 diabetes
* Non smoker
* Normal lung function

Exclusion Criteria

* Pulmonary, hepatic, or renal disease
* Congestive heart failure
* Active malignancy
* Systemic glucocorticoid therapy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Alkermes, Inc.

INDUSTRY

Sponsor Role collaborator

Eli Lilly and Company

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern Time (UTC/GMT - 5 hours, EST)

Role: STUDY_DIRECTOR

Eli Lilly and Company

Locations

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For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.

Sacramento, California, United States

Site Status

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Santa Ana, California, United States

Site Status

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Jacksonville, Florida, United States

Site Status

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Miami, Florida, United States

Site Status

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Baton Rouge, Louisiana, United States

Site Status

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Hamilton, New Jersey, United States

Site Status

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Greenville, South Carolina, United States

Site Status

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Ogden, Utah, United States

Site Status

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Charleston, West Virginia, United States

Site Status

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Fortaleza, , Brazil

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Porto Alegre, , Brazil

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São Paulo, , Brazil

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Berlin, , Germany

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Dresden, , Germany

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Erlangen, , Germany

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Frankfurt, , Germany

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Leipzig, , Germany

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Mainz, , Germany

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Budapest, , Hungary

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Makó, , Hungary

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Veszprém, , Hungary

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Zalaegerszeg, , Hungary

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Bangalore, , India

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Mumbai, , India

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Pune, , India

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Catania, , Italy

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Genova, , Italy

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Milan, , Italy

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Pisa, , Italy

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Rome, , Italy

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Mexico City, , Mexico

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Monterrey, , Mexico

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Katowice, , Poland

Site Status

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Lublin, , Poland

Site Status

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Oleśnica, , Poland

Site Status

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Coimbra, , Portugal

Site Status

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Lisbon, , Portugal

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Manatí, , Puerto Rico

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San Juan, , Puerto Rico

Site Status

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Yabucoa, , Puerto Rico

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Changhua, , Taiwan

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Neihu Taipei, , Taiwan

Site Status

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Yungkang City, , Taiwan

Site Status

Countries

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United States Brazil Germany Hungary India Italy Mexico Poland Portugal Puerto Rico Taiwan

References

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Gross JL, Nakano M, Colon-Vega G, Ortiz-Carasquillo R, Ferguson JA, Althouse S, Tobian JA, Berclaz PY, Milicevic Z. Initiation of prandial insulin therapy with AIR inhaled insulin or insulin lispro in patients with type 2 diabetes: A randomized noninferiority trial. Diabetes Technol Ther. 2009 Sep;11 Suppl 2:S27-34. doi: 10.1089/dia.2009.0037.

Reference Type RESULT
PMID: 19772446 (View on PubMed)

Other Identifiers

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H7U-MC-IDAU

Identifier Type: OTHER

Identifier Source: secondary_id

9626

Identifier Type: -

Identifier Source: org_study_id

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