Clofarabine and Cyclophosphamide in Treating Patients With Relapsed or Refractory Acute Leukemia, Chronic Myelogenous Leukemia, or Myeloproliferative Disorders

NCT ID: NCT00293410

Last Updated: 2010-05-06

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE1
• Total Enrollment: 70 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2005-11-30

Brief Summary

RATIONALE: Drugs used in chemotherapy, such as clofarabine and cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more cancer cells.

PURPOSE: This phase I trial is studying the side effects and best dose of clofarabine and cyclophosphamide in treating patients with relapsed or refractory acute leukemia, chronic myelogenous leukemia, or myeloproliferative disorders.

Detailed Description

OBJECTIVES:

Primary

• Determine the feasibility and tolerability of administering clofarabine and fractionated cyclophosphamide in patients with relapsed or refractory acute leukemia, chronic myelogenous leukemia, or high-risk myeloproliferative disorders
• Determine the maximum tolerated dose of clofarabine and fractionated cyclophosphamide in these patients.
• Determine the toxic effects of these drugs in these patients.

Secondary

• Obtain preliminary data of biologic and pharmacodynamic effects of this regimen on marrow and circulating leukemic blasts in these patients.

OUTLINE: This is a dose-escalation study. Patients are stratified according to age (adult vs child).

Patients receive cyclophosphamide IV over 2 hours on day 0. Patients then receive clofarabine IV over 2 hours and cyclophosphamide IV over 2 hours on days 1-3 and 8-10. Treatment with clofarabine and cyclophosphamide repeats every 28 days for at least 2 courses in the absence of disease progression or unacceptable toxicity.

Cohorts of 3-6 patients receive escalating doses of clofarabine and cyclophosphamide until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. At least 10 patients are treated at the MTD.

After completion of study treatment, patients are followed periodically for 1 year.

PROJECTED ACCRUAL: A total of 70 patients will be accrued for this study.

Conditions

Chronic Myeloproliferative Disorders; Leukemia; Myelodysplastic/Myeloproliferative Diseases

Study Design

• Primary Study Purpose: TREATMENT

Interventions

clofarabine

Intervention Type: DRUG

cyclophosphamide

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Chronic myelogenous leukemia in accelerated phase or blast crisis
• High-risk MPD, including any of the following:

• Myelofibrosis
• Chronic myelomonocytic leukemia with 5%-19% blasts
• Relapsed or refractory juvenile myelomonocytic leukemia
• Relapsed and/or refractory disease with progressive disease since last therapy

• No more than 3 prior induction regimens with cytotoxic agents for adults
• Must be in second relapse for patients < 21 years of age

PATIENT CHARACTERISTICS:

• ECOG performance status 0-2 (for adults) OR Lansky 50-100% (for pediatric patients)
• Bilirubin ≤ 1.5 mg/dL (may be elevated due to hemolysis in adult patients)
• AST and ALT ≤ 5 times upper limit of normal
• Creatinine ≤ 2.0 mg/dL (for adults)
• Normal renal function (for pediatric patients)
• Cardiac function normal as measured by MUGA scan or echocardiogram
• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective barrier contraception during and for at least 6 months after completion of study treatment
• HIV negative
• No active graft-versus-host disease ≥ grade 2
• No active, uncontrolled infection
• No fever
• No unstable CT scans of the lungs, sinuses, or abdomen within the past 4 weeks
• No arrhythmias (other than atrial flutter or fibrillation) requiring medication
• No dyspnea at rest or with minimal exertion
• No uncontrolled congestive heart failure
• No myocardial infarction within the past 3 months
• No history of severe coronary artery disease
• No other significant concurrent disease, illness, or psychiatric disorder that would compromise patient safety or compliance or interfere with consent, study participation, follow up, or interpretation of study results

PRIOR CONCURRENT THERAPY:

• Must have recovered from all acute toxic effects from prior treatment
• More than 30 days since prior investigational cytotoxic agents
• At least 3 days since prior azacitidine, thalidomide, hydroxyurea, imatinib mesylate, or interferon
• At least 1 week since prior growth factors except epoetin alfa
• More than 3 weeks since any other prior anticancer therapy
• No concurrent chemotherapy, radiotherapy, or immunotherapy
• No other concurrent anticancer investigational or commercial agents
• No routine prophylactic use of a colony-stimulating factor (filgrastim [G-CSF] or sargramostim [GM-CSF])

• Therapeutic use of colony-stimulating factors may be considered at the discretion of the investigator
• No prolonged use of corticosteroids to prevent or treat emesis or as a chemotherapeutic agent

• Minimum Eligible Age: 2 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

National Cancer Institute (NCI)

NIH

Sponsor Role: collaborator

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

OTHER

Sponsor Role: lead

Principal Investigators

Judith E. Karp, MD

Role: STUDY_CHAIR

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Locations

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Baltimore, Maryland, United States

Countries

United States

References

Karp JE, Ricklis RM, Balakrishnan K, Briel J, Greer J, Gore SD, Smith BD, McDevitt MA, Carraway H, Levis MJ, Gandhi V. A phase 1 clinical-laboratory study of clofarabine followed by cyclophosphamide for adults with refractory acute leukemias. Blood. 2007 Sep 15;110(6):1762-9. doi: 10.1182/blood-2007-03-081364. Epub 2007 Jun 11.

Reference Type: DERIVED

PMID: 17562873 (View on PubMed)

Other Identifiers

P30CA006973

Identifier Type: NIH

Identifier Source: secondary_id

View Link

JHOC-J0561

Identifier Type: -

Identifier Source: secondary_id

JHOC-00000845

Identifier Type: -

Identifier Source: secondary_id

J0561 CDR0000456431

Identifier Type: -

Identifier Source: org_study_id