Montelukast in Pediatric Allergic Asthma (0476-336)(COMPLETED)

NCT ID: NCT00289874

Last Updated: 2022-02-02

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

421 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-03-31

Study Completion Date

2007-07-31

Brief Summary

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This is a 3-week study to evaluate FEV1 following treatment with drugs in persistent asthma which is also active during allergy seasons in pediatric patients with seasonal aeroallergen sensitivity.

Detailed Description

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Conditions

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Asthma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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1

montelukast

Group Type EXPERIMENTAL

montelukast sodium

Intervention Type DRUG

montelukast 5 mg chewable tablet once daily. Up to 3 weeks of treatment.

2

placebo

Group Type PLACEBO_COMPARATOR

Comparator: Placebo

Intervention Type DRUG

Placebo. Up to 3 weeks of treatment

Interventions

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montelukast sodium

montelukast 5 mg chewable tablet once daily. Up to 3 weeks of treatment.

Intervention Type DRUG

Comparator: Placebo

Placebo. Up to 3 weeks of treatment

Intervention Type DRUG

Other Intervention Names

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MK0476

Eligibility Criteria

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Inclusion Criteria

* Male and female patients, ages 6 to 14 years, with persistent asthma that is also active during allergy season
* Patients must demonstrate positive skin prick tests to seasonally relevant geographic aeroallergens

Exclusion Criteria

* Patient cannot have any other acute or chronic pulmonary disorder
Minimum Eligible Age

6 Years

Maximum Eligible Age

14 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Organon and Co

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Medical Monitor

Role: STUDY_DIRECTOR

Merck Sharp & Dohme LLC

References

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Papadopoulos NG, Philip G, Giezek H, Watkins M, Smugar SS, Polos PG. The efficacy of montelukast during the allergy season in pediatric patients with persistent asthma and seasonal aeroallergen sensitivity. J Asthma. 2009 May;46(4):413-20. doi: 10.1080/02770900902847727.

Reference Type BACKGROUND
PMID: 19484680 (View on PubMed)

Other Identifiers

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2006_001

Identifier Type: -

Identifier Source: secondary_id

0476-336

Identifier Type: -

Identifier Source: org_study_id

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