The Incidence and Treatment of Insulin Resistance Among Men With Erectile Dysfunction

NCT ID: NCT00284960

Last Updated: 2017-08-03

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 30 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2005-06-30
• Study Completion Date: 2007-03-31

Brief Summary

Determine if men with erectile dysfunction (ED) are more likely to have insulin resistance compared to healthy controls.

Detailed Description

Insulin is a hormone produced by the body that lets sugar into the cells, where it is used for energy. Insulin resistance occurs when the body's cells have a decreased ability to react to insulin. This leads to an increase in insulin secretion. Over time, insulin resistance can lead to higher levels of sugar in the blood (diabetes), and can also contribute to obesity, high blood pressure, high cholesterol levels and heart disease. There are no simple tests to actually diagnose insulin resistance. Currently, the glucose tolerance test is used to diagnose IR, but it involves several blood draws over a 2-hour period. Another purpose of this study is to compare a blood test involving only one blood draw to the 2-hour glucose tolerance test, which involves several blood draws over a 2-hour period.

It is well known that diabetes often leads to erectile dysfunction. Because insulin resistance occurs before diabetes, it is possible that erectile dysfunction may occur in some individuals while they have insulin resistance, but before they develop diabetes. If this is true, it might be possible to use erectile dysfunction as a sign of insulin resistance, which may lead to more timely treatment of insulin resistance and may delay or prevent the development of diabetes, and the other problems mentioned above.

Conditions

Erectile Dysfunction; Metabolic Syndrome; Insulin Resistance

Study Design

• Study Time Perspective: PROSPECTIVE

Eligibility Criteria

Inclusion Criteria

• 18-65 years of age, male,

Exclusion Criteria

• diabetes, peyronies

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

Milton S. Hershey Medical Center

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

J C Trussell, MD

Role: PRINCIPAL_INVESTIGATOR

Locations

Hershey Med Center

Hershey, Pennsylvania, United States

Countries

United States

Other Identifiers

NIH: K24 H001476

Identifier Type: -

Identifier Source: secondary_id

18805

Identifier Type: -

Identifier Source: org_study_id