Oligodendrocyte Progenitor Cell Culture From Human Brain

NCT ID: NCT00283023

Last Updated: 2020-10-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE1

Total Enrollment

5 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-12-31

Study Completion Date

2010-12-31

Brief Summary

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Recent developments in the understanding of stem- and progenitor cell differentiation raises hopes that brain damage in chronic neurological diseases may become repaired by systemic or focal transplantation of such cells. Clinical trials of stem- or progenitor cell transplantation in multiple sclerosis are currently premature. The researchers developed a protocol for human oligodendrocyte progenitor cell culture from human brain for the treatment of demyelinating disease.

Detailed Description

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Oligodendrocyte progenitor cell line were cultures and will be transplanted into the patient with Multiple sclerosis.

Conditions

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Demyelinating Diseases

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Cell culture
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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A

Progenitor cells from the patinets with Craniotomy with V-P Shunt or ventriculostomy will be collected and cultured.

Group Type EXPERIMENTAL

Oligodendrocyte progenitor cell culture/craniotomy

Intervention Type PROCEDURE

Oligodendrocyte progenitor cell culture protocol of Rajavithi Hospital will be apply

Interventions

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Oligodendrocyte progenitor cell culture/craniotomy

Oligodendrocyte progenitor cell culture protocol of Rajavithi Hospital will be apply

Intervention Type PROCEDURE

Other Intervention Names

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Rajavithi Oligodendrocyte progenitor cell culture protocol

Eligibility Criteria

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Inclusion Criteria

* Male or female 20-65 years of age
* Informed consent
* Has elective craniotomy surgery

Exclusion Criteria

* HIV, hepatitis, and other central nervous system (CNS) infections
* Dementia, Alzheimer disease, and neurodegenerative disease
Minimum Eligible Age

20 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Department of Medical Services Ministry of Public Health of Thailand

OTHER_GOV

Sponsor Role lead

Responsible Party

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Rajavithi Hospital

Principal Investigators

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Subsai Kongsaengdao, M.D.

Role: PRINCIPAL_INVESTIGATOR

Division of Neurology, Department of Medicine, Rajavithi Hospital : Thailand

Locations

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Assistant Professor Subsai Kongsaengdao

Bangkok, , Thailand

Site Status

Countries

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Thailand

Other Identifiers

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RVH-CMR-003 grant

Identifier Type: -

Identifier Source: secondary_id

RH-CMR-003

Identifier Type: -

Identifier Source: org_study_id

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