Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed By Surgery

NCT ID: NCT00274872

Last Updated: 2010-02-01

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: PHASE2/PHASE3
• Total Enrollment: 600 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2004-01-31

Brief Summary

RATIONALE: Drugs used in chemotherapy, such as oxaliplatin, leucovorin, and fluorouracil, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells. It is not yet known which combination chemotherapy regimen is more effective in treating colorectal cancer.

PURPOSE: This randomized phase II/III trial is studying two combination chemotherapy regimens to compare how well they work in treating patients with metastatic colorectal cancer that cannot be removed by surgery.

Detailed Description

OBJECTIVES:

Primary

• Compare progression-free survival of patients with inoperable metastatic colorectal cancer treated with oxaliplatin, leucovorin calcium, and fluorouracil with vs without maintenance leucovorin calcium and fluorouracil.
• Demonstrate that time of disease control (TDC) can be increased by 15% at 9 months and that maintenance therapy can be avoided.

Secondary

• Compare the overall survival and response rate in patients treated with these regimens.
• Compare the salvage surgery rate in patients treated with these regimens.
• Compare the tolerability of these regimens in these patients.
• Compare the quality of life in patients treated with these regimens.
• Compare the duration of chemotherapy-free intervals in patients treated with these regimens.
• Compare the pharmacoeconomy and pharmacogenetics of these regimens in these patients.

OUTLINE: This is a randomized, controlled, open-label, multicenter study. Patients are stratified according to participating center, performance status (0-1 vs 2), number of metastatic sites (1 vs > 1), age (18-50 years vs 51-75 years vs 76-80 years), adjuvant chemotherapy, and baseline alkaline phosphatase (≤ 3 times upper limit of normal [ULN] vs > 3 times ULN). Patients are randomized to 1 of 2 treatment arms.

Arm I

• FOLFOX chemotherapy: Patients receive oxaliplatin IV over 2 hours and leucovorin calcium IV over 2 hours on day 1 and fluorouracil IV continuously over 46 hours on days 1 and 2. Treatment repeats every 14 days for 6 courses in the absence of disease progression or unacceptable toxicity. Patients then proceed to maintenance chemotherapy.
• Maintenance chemotherapy: Patients receive leucovorin calcium IV over 2 hours on day 1 and fluorouracil IV continuously over 46 hours on days 1 and 2. Courses repeat every 14 days in the absence of disease progression or unacceptable toxicity.

Patients with disease progression on maintenance chemotherapy receive 6 additional courses of FOLFOX as above. Patients with continued disease progression while receiving the additional courses of FOLFOX proceed to irinotecan-based chemotherapy off study.

Arm II

• FOLFOX chemotherapy: Patients receive 6 courses of FOLFOX as in arm I. Patients with disease progression on FOLFOX receive 6 additional courses of FOLFOX. Patients with continued disease progression while receiving the additional courses of FOLFOX proceed to irinotecan-based chemotherapy off study.

In both arms, patients with stable or responding disease may undergo surgical resection after completion of the initial 6 courses of FOLFOX.

Quality of life is assessed at baseline, after courses 4 and 6, and then every 2-3 months thereafter.

After completion of study treatment, patients are followed at 1 month and then every 3 months thereafter.

PROJECTED ACCRUAL: A total of 600 patients will be accrued for this study.

Conditions

Colorectal Cancer

Study Design

• Allocation Method: RANDOMIZED
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Interventions

fluorouracil

Intervention Type: DRUG

leucovorin calcium

Intervention Type: DRUG

oxaliplatin

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

DISEASE CHARACTERISTICS:

• Histologically proven adenocarcinoma of the colon or rectum

• Metastatic disease

• No metastases involving only the bone
• Inoperable disease (i.e., not suitable for complete surgical resection)
• Measurable or evaluable disease

• Measurable disease defined as ≥ 1 unidimensionally measurable lesion ≥ 20 mm by conventional CT scan OR ≥ 10 mm by spiral CT scan
• No symptomatic ascites or pleural effusion that has not been evacuated
• No CNS metastasis

PATIENT CHARACTERISTICS:

• WHO OR ECOG performance status 0-2
• Absolute neutrophil count ≥ 1,500/mm^3
• Platelets ≥ 100,000/mm^3
• Creatinine < 3 times upper limit of normal (ULN)
• Alkaline phosphatase < 5 times ULN
• No peripheral neuropathy ≥ grade 1
• No total or partial bowel obstruction
• Not pregnant or nursing
• Fertile patients must use effective contraception
• No uncontrolled hypercalcemia
• No other concurrent or prior malignancy, except adequately treated carcinoma in situ of the uterine cervix or basal or squamous cell carcinoma of the skin or cancer in complete remission for ≥ 5 years
• No uncontrolled congestive heart failure
• No angina pectoris
• No hypertension
• No arrhythmias
• No history of significant neurologic or psychiatric disorders
• No active infection
• No other serious nonmalignant disease

PRIOR CONCURRENT THERAPY:

• No prior chemotherapy and/or immunotherapy for metastatic disease
• Prior adjuvant chemotherapy allowed provided progression-free interval after completion of adjuvant chemotherapy is > 6 months
• No other concurrent anticancer treatment
• No participation in another clinical trial with any investigational drug within 30 days prior to randomization
• No other concurrent investigational treatment
• No concurrent radiotherapy
• No concurrent cold cap for prevention of alopecia or iced mouth rinses for prevention of stomatitis

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

GERCOR - Multidisciplinary Oncology Cooperative Group

OTHER

Sponsor Role: lead

Principal Investigators

Aimery de Gramont, MD

Role: STUDY_CHAIR

Hopital Saint Antoine

Locations

Institut Sainte Catherine

Avignon, , France

Hopital Duffaut

Avignon, , France

Infirmerie Protestante

Caluire-et-Cuire, , France

Hopital Drevon

Dijon, , France

Centre Hospitalier de Dreux

Dreux, , France

Hopital Louis Pasteur - Le Coudray

Le Coudray, , France

Clinique Victor Hugo

Le Mans, , France

Hopital Robert Boulin

Libourne, , France

Clinique Saint Jean

Lyon, , France

Intercommunal Hospital

Montfermeil, , France

Hopital Europeen Georges Pompidou

Paris, , France

Hopital Saint Antoine

Paris, , France

Hopital Tenon

Paris, , France

Polyclinique De Courlancy

Reims, , France

C.H. Senlis

Senlis, , France

Clinique des Jockeys

Senlis, , France

Centre Medico-Chirurgical Foch

Suresnes, , France

Countries

France

References

Chibaudel B, Maindrault-Goebel F, Lledo G, Mineur L, Andre T, Bennamoun M, Mabro M, Artru P, Carola E, Flesch M, Dupuis O, Colin P, Larsen AK, Afchain P, Tournigand C, Louvet C, de Gramont A. Can chemotherapy be discontinued in unresectable metastatic colorectal cancer? The GERCOR OPTIMOX2 Study. J Clin Oncol. 2009 Dec 1;27(34):5727-33. doi: 10.1200/JCO.2009.23.4344. Epub 2009 Sep 28.

Reference Type: RESULT

PMID: 19786657 (View on PubMed)

Other Identifiers

GERCOR-OPTIMOX2

Identifier Type: -

Identifier Source: secondary_id

GERCOR-OPTIMOX2-2003

Identifier Type: -

Identifier Source: secondary_id

GERCOR-OPTIMOX2-C02-2

Identifier Type: -

Identifier Source: secondary_id

EU-20566

Identifier Type: -

Identifier Source: secondary_id

SANOFI-GERCOR-OPTIMOX2

Identifier Type: -

Identifier Source: secondary_id

CDR0000453890

Identifier Type: -

Identifier Source: org_study_id