Efficacy & Safety of Symbicort® TURBUHALER® 160/4.5 µg Twice Daily & Pulmicort® TURBUHALER® 200 µg Twice Daily + Theolong® Tablet 200 mg Twice Daily in Japanese Asthmatic Patients

NCT ID: NCT00252785

Last Updated: 2011-01-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

340 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-10-31

Study Completion Date

2006-11-30

Brief Summary

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The primary objective of this study is to confirm the efficacy (superiority) of Symbicort® Turbuhaler® 160/4.5 µg twice daily for 8 weeks in comparison to Pulmicort® Turbuhaler® 200 µg twice daily + Theolong® tablet 200 mg twice daily.

Detailed Description

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Conditions

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Asthma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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Budesonide/Formoterol

Intervention Type DRUG

Budesonide

Intervention Type DRUG

Theophylline

Intervention Type DRUG

Other Intervention Names

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Symbicort

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of asthma with a documented history of at least 6 months duration prior to Visit 1
* Prescribed daily use of an IGCS for \>=12 weeks prior to Visit 1. The dose of IGCS must be 400 to 800 µg/day of Pulmicort® Turbuhaler® or corresponding dose of IGCS. The prescribed dose of IGCS should be constant for at least 4 weeks prior to Visit 1
* Prescribed daily use of sustained release theophylline for at least 8 weeks prior to Visit 1, or confirmed steady-state blood theophylline concentrations within the effective range (5-15 µg/mL) during 8 weeks prior to Visit 1. The prescribed dose of theophylline should be constant (400 mg/day) for at least 4 weeks prior to Visit 1

Exclusion Criteria

* Any significant disease or disorder that may jeopardize the safety of the patient
* Respiratory infection, judged by the investigator(s) as an infection affecting the asthma, within 4 weeks prior to Visit 1
* Treatment with oral, parenteral or rectal GCS within 4 weeks prior to Visit 1
Minimum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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AstraZeneca

INDUSTRY

Sponsor Role lead

Principal Investigators

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AstraZeneca Symbicort Medical Science Director, MD

Role: STUDY_DIRECTOR

AstraZeneca

Locations

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Research Site

Komaki, Aichi-ken, Japan

Site Status

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Seto, Aichi-ken, Japan

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Asahi, Chiba, Japan

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Noda, Chiba, Japan

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Touon, Ehime, Japan

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Miyaodai, Fukuoka, Japan

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Gifu, Gifu, Japan

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Isesaki, Gunma, Japan

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Maebashi, Gunma, Japan

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Ōta, Gunma, Japan

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Ōwa, Gunma, Japan

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Hiroshima, Hiroshima, Japan

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Chitose, Hokkaido, Japan

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Kitahiroshima, Hokkaido, Japan

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Obihiro, Hokkaido, Japan

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Sapporo, Hokkaido, Japan

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Tomakomai, Hokkaido, Japan

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Morioka, Iwate, Japan

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Takamatsu, Kagawa-ken, Japan

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Kagoshima, Kagoshima-ken, Japan

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Kyoto, Kyoto, Japan

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Sendai, Miyagi, Japan

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Beppu, Ohita, Japan

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Ōita, Oita Prefecture, Japan

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Okayama, Okayama-ken, Japan

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Tsukubo, Okayama-ken, Japan

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Kishiwada, Osaka, Japan

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Osaka, Osaka, Japan

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Oskasayama, Osaka, Japan

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Takatsuiki, Osaka, Japan

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Koshigaya, Saitama, Japan

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Minamisaitama, Saitama, Japan

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Arakawa City, Tokyo, Japan

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Chiyoda City, Tokyo, Japan

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Kodaira, Tokyo, Japan

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Nakano-ku, Tokyo, Japan

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Ōta-ku, Tokyo, Japan

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Shinagawa-ku, Tokyo, Japan

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Sumida City, Tokyo, Japan

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tabashi City, Tokyo, Japan

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Toyama, Toyama, Japan

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Ube, Yamaguchi, Japan

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Tochigi, , Japan

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Countries

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Japan

Other Identifiers

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D5890C00010

Identifier Type: -

Identifier Source: org_study_id

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