Clozapine-Augmentation With Ziprasidone or Risperidone, a Randomized, Prospective Trial

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

24 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-11-30

Study Completion Date

2006-09-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

We aim to compare the augmentation of clozapine with ziprasidone or risperidone in a randomized, prospective manner.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Risperidone Augmentation in Patients With Schizophrenia

NCT00289861

Schizophrenia

COMPLETED PHASE4

Effect And Safety Of Ziprasidone Compared To Other Atypical Antipsychotic Drug In Schizophrenic Patients

NCT00159770

Schizophrenia Schizoaffective Disorder Psychotic Disorders

COMPLETED PHASE3

Efficacy and Tolerability of Switching to Ziprasidone From Other Antipsychotics

NCT00458211

Schizophrenia Schizoaffective Disorder

COMPLETED PHASE4

A Study Comparing the Efficacy and Tolerability of Ziprasidone vs. Clozapine for the Treatment of Schizophrenia in Patients Who Continue to Have Symptoms on or Cannot Tolerate Other Antipsychotic Drugs

NCT00649844

Schizophrenia

COMPLETED PHASE3

A Study Comparing the Safety and Efficacy of Ziprasidone and Risperidone for the Treatment of Chronic Schizophrenia

NCT00645515

Schizophrenia

TERMINATED PHASE3

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Partial response of schizophrenic psychoses to a monotherapy with clozapine is a frequent problem of clinical psychiatry. Current problems are treatment resistant positive and/or negative symptoms, as well as side effects. Therefore, different strategies of augmentations have been applied. Based on successful experiences in case reports and results of other work groups, we aim to compare the augmentation of clozapine with ziprasidone or risperidone in a randomized, prospective manner.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Schizophrenia, Schizoaffective Disorder

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

ziprasidone

Intervention Type DRUG

risperidone

Intervention Type DRUG

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Treatment resistant schizophrenic or schizoaffective disorder under therapy with clozapine,
* Age between 18 and 70,
* Informed consent

Exclusion Criteria

* No informed consent,
* Intolerance with respect to ziprasidone or risperidone,
* Contraindications with respect to these substances,
* Gravidity or missing anticonceptive safety
* Substance dependance (excluded nicotin)

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No