The Evaluation of the Safety of a New Drug for Benign Prostatic Hyperplasia Used for 9 Months

NCT ID: NCT00224133

Last Updated: 2010-04-27

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

661 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-09-30

Study Completion Date

2007-04-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

A new drug for benign prostatic hyperplasia is used for 9 months to determine its long-term safety.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

This will be a multi-center, open-label 40 week investigation in up to 1,200 men with signs and symptoms of benign prostatic hyperplasia. The following procedures are utilized: physical exams, electrocardiograms, clinical laboratory tests, vital signs, the International Prostate Symptom Score, maximum urine flow rate, adverse events, concomitant medications, and compliance.

All subjects had previously participated in a 12-week double-blind placebo controlled trial (NCT000224107 or NCT000224120)

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Benign Prostatic Hyperplasia

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Silodosin

Silodosin 8 mg per day with food

Group Type EXPERIMENTAL

Silodosin

Intervention Type DRUG

8 mg daily

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Silodosin

8 mg daily

Intervention Type DRUG

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Rapaflo

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Males in good general health and at least 50 years of age, who have completed SI04009 or SI04010.

Exclusion Criteria

* Medical conditions that would confound the efficacy evaluation.
* Medical conditions in which it would be unsafe to use an alpha-blocker.
* The use of concomitant drugs that would confound the efficacy evaluation.
* The use of concomitant drugs that would be unsafe with this alpha-blocker.
Minimum Eligible Age

50 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Watson Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Watson Laboratories, Inc.

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Lawrence Hill, Pharm D, RPh

Role: STUDY_DIRECTOR

Watson Pharmaceuticals

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Birmingham, Alabama, United States

Site Status

Huntsville, Alabama, United States

Site Status

Tucson, Arizona, United States

Site Status

Anaheim, California, United States

Site Status

Carmichael, California, United States

Site Status

Culver City, California, United States

Site Status

Fresno, California, United States

Site Status

Irvine, California, United States

Site Status

La Jolla, California, United States

Site Status

Laguna Woods, California, United States

Site Status

Long Beach, California, United States

Site Status

Newport Beach, California, United States

Site Status

San Bernardino, California, United States

Site Status

San Diego, California, United States

Site Status

Tarzana, California, United States

Site Status

Torrance, California, United States

Site Status

Aurora, Colorado, United States

Site Status

Wheat Ridge, Colorado, United States

Site Status

Waterbury, Connecticut, United States

Site Status

Aventura, Florida, United States

Site Status

Clearwater, Florida, United States

Site Status

Coral Gables, Florida, United States

Site Status

New Port Richey, Florida, United States

Site Status

Ocala, Florida, United States

Site Status

Orlando, Florida, United States

Site Status

Pensacola, Florida, United States

Site Status

Plantation, Florida, United States

Site Status

Tampa, Florida, United States

Site Status

West Palm Beach, Florida, United States

Site Status

Marietta, Georgia, United States

Site Status

Chicago, Illinois, United States

Site Status

Melrose Park, Illinois, United States

Site Status

Peoria, Illinois, United States

Site Status

Evansville, Indiana, United States

Site Status

Fort Wayne, Indiana, United States

Site Status

Des Moines, Iowa, United States

Site Status

Overland Park, Kansas, United States

Site Status

Greenbelt, Maryland, United States

Site Status

Boston, Massachusetts, United States

Site Status

Saint Joseph, Michigan, United States

Site Status

Edina, Minnesota, United States

Site Status

Jackson, Mississippi, United States

Site Status

Kansas City, Missouri, United States

Site Status

Missoula, Montana, United States

Site Status

Las Vegas, Nevada, United States

Site Status

Lawrenceville, New Jersey, United States

Site Status

Voorhees Township, New Jersey, United States

Site Status

Albuquerque, New Mexico, United States

Site Status

Albany, New York, United States

Site Status

Bay Shore, New York, United States

Site Status

Garden City, New York, United States

Site Status

Kingston, New York, United States

Site Status

Manhasset, New York, United States

Site Status

New York, New York, United States

Site Status

Poughkeepsie, New York, United States

Site Status

Staten Island, New York, United States

Site Status

Williamsville, New York, United States

Site Status

Charlotte, North Carolina, United States

Site Status

Concord, North Carolina, United States

Site Status

Salisbury, North Carolina, United States

Site Status

Winston-Salem, North Carolina, United States

Site Status

Cincinnati, Ohio, United States

Site Status

Bethany, Oklahoma, United States

Site Status

Portland, Oregon, United States

Site Status

Lancaster, Pennsylvania, United States

Site Status

Providence, Rhode Island, United States

Site Status

Greer, South Carolina, United States

Site Status

Mt. Pleasant, South Carolina, United States

Site Status

Myrtle Beach, South Carolina, United States

Site Status

Austin, Texas, United States

Site Status

Dallas, Texas, United States

Site Status

San Antonio, Texas, United States

Site Status

Salt Lake City, Utah, United States

Site Status

Norfolk, Virginia, United States

Site Status

Lakewood, Washington, United States

Site Status

Seattle, Washington, United States

Site Status

Tacoma, Washington, United States

Site Status

Madison, Wisconsin, United States

Site Status

Milwaukee, Wisconsin, United States

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States

References

Explore related publications, articles, or registry entries linked to this study.

Marks LS, Gittelman MC, Hill LA, Volinn W, Hoel G. Silodosin in the treatment of the signs and symptoms of benign prostatic hyperplasia: a 9-month, open-label extension study. Urology. 2009 Dec;74(6):1318-22. doi: 10.1016/j.urology.2009.06.072. Epub 2009 Oct 7.

Reference Type RESULT
PMID: 19815265 (View on PubMed)

Related Links

Access external resources that provide additional context or updates about the study.

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

SI04011

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

A Study in Benign Prostatic Hyperplasia
NCT01152190 COMPLETED PHASE3