A Study of HSV Testing Among Pregnant Women

NCT ID: NCT00194415

Last Updated: 2008-01-10

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

173 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-01-31

Study Completion Date

2006-11-30

Brief Summary

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The objective of the study is to evaluate the acceptance and effect of type- specific HSV serologic testing of pregnant women on sexual behavior at the end of pregnancy.

Detailed Description

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The study hypothesis is that women with antepartum testing who are identified as susceptible to HSV-1 or HSV-2 will have reduced unprotected coital activity and reduced unprotected oral-genital activity compared to those who did not receive antepartum testing. The objective of the study is to evaluate the acceptance, and effect of type-specific HSV serologic testing of pregnant women on sexual behavior at the end of pregnancy.

Upon enrollment, study participants will be randomized into either of two type-specific HSV serologic testing and counseling regimens:

* Group 1: Antepartum and postpartum testing. Subjects will be made aware of their antepartum testing results.
* Group 2: Antepartum blood draw and postpartum testing. Subjects' specimens will be tested at the same time.

Women in group 2 will receive information about herpes infection and how to decrease their chance of acquiring infection during pregnancy. Subjects will be asked to keep a diary of sexual activity and return to the clinic every 4 weeks until delivery.

Conditions

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Herpes Simplex Pregnancy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

NONE

Study Groups

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1

HSV-2 antepartum testing

Group Type OTHER

Type specific serologic HSV testing

Intervention Type PROCEDURE

Subjects will be testing for HSV by Western Blot

2

Subjects will receive safer-sex counseling during pregnancy

Group Type OTHER

Safer-sex counseling

Intervention Type BEHAVIORAL

Subjects will receive safer-sex counseling during pregnancy

Interventions

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Safer-sex counseling

Subjects will receive safer-sex counseling during pregnancy

Intervention Type BEHAVIORAL

Type specific serologic HSV testing

Subjects will be testing for HSV by Western Blot

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* 14 years of age or older
* Pregnant less than 28 weeks at time of enrollment
* No previous HSV serology within the past year
* able to comprehend english

Exclusion Criteria

* History of genital herpes
* HIV seropositive
* Any contraindication for sexual activity during pregnancy
Minimum Eligible Age

14 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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National Institutes of Health (NIH)

NIH

Sponsor Role collaborator

University of Washington

OTHER

Sponsor Role lead

Responsible Party

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University of Washington

Principal Investigators

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Deborah Money, MD

Role: PRINCIPAL_INVESTIGATOR

University of British Columbia

Anna Wald, MD, MPH

Role: PRINCIPAL_INVESTIGATOR

University of Washington

Locations

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Children's & Women's Health Centre of British Columbia

Vancouver, British Columbia, Canada

Site Status

Countries

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Canada

Other Identifiers

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P01AI030731

Identifier Type: NIH

Identifier Source: secondary_id

View Link

03-9950-E/A

Identifier Type: -

Identifier Source: org_study_id

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