Assist Control Versus Pressure Support Modes for Domiciliary Noninvasive Ventilation in Chronic Respiratory Failure

NCT ID: NCT00189527

Last Updated: 2011-02-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-01-31

Study Completion Date

2009-10-31

Brief Summary

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Noninvasive ventilation is a therapeutic option in some patients with chronic respiratory failure. Patients usually ventilate during nightime with a domiciliary ventilator either in assist control or in pressure support mode.

The aim of this study is to compare the clinical efficacy and the tolerance of assist control and pressure support modes during domiciliary noninvasive ventilation in patients with chronic respiratory failure.

Detailed Description

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The aim of this study is to compare the clinical efficacy and the tolerance of assist control and pressure support modes during domiciliary noninvasive ventilation in patients with chronic respiratory failure.

Conditions

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Chronic Respiratory Failure

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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respiratory support

a mode of ventilation in comparison

Group Type EXPERIMENTAL

respiratory settings

Intervention Type PROCEDURE

Assist Control

an other mode of ventilation in comparison

Group Type ACTIVE_COMPARATOR

respiratory settings

Intervention Type PROCEDURE

Interventions

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respiratory settings

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Chronic respiratory failure
* Clinical symptoms of chronic alveolar hypoventilation
* PaCO2 ≥ 45 mmHg in case of restrictive pulmonary disorder or PaCO2 ≥ 55 mmHg in case or obstructive pulmonary disorder

Exclusion Criteria

* Clinical exacerbation during the three previous weeks
* Previous treatment by domiciliary non invasive ventilation
* Previous treatment by non invasive ventilation for acute respiratory failure during the 3 previous months
* Bronchiectasis
* Duchenne muscular dystrophy
* Amyotrophic lateral sclerosis
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Association Nationale pour les Traitements A Domicile, les Innovations et la Recherche

OTHER

Sponsor Role lead

Responsible Party

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CHU Rouen

Principal Investigators

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Antoine CUVELIER, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Rouen

Other Identifiers

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2000-2

Identifier Type: -

Identifier Source: org_study_id

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