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Collection of Bone Marrow Aspirate From Volunteer Donors

NCT ID: NCT00183066

Last Updated: 2012-08-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

63 participants

Study Classification

OBSERVATIONAL

Study Start Date

2002-07-31

Study Completion Date

2012-08-31

Brief Summary

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The purpose of this study is to collect bone marrow cells for research purposes.

Detailed Description

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This study is designed to provide bone marrow cells for other research studies. The research is being done because there are ongoing experiments in a number of National Institute on Aging (NIA) laboratories that require access to normal human bone marrow aspirate for their studies of the immune system. These studies are done to understand how blood cells are formed and how they function. Samples will be used to study problems such as the immune system in bone marrow failure and related conditions. Cells will be used in laboratory research and may be banked for future laboratory studies

Conditions

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Aging

Study Design

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Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Healthy volunteers age 18 and over

Exclusion Criteria

* Significant abnormalities on health history questionnaire or in the results of blood tests
* Pregnant or nursing mother
* Participation in another research study within the past six weeks that is felt by the Principal Investigator to be incompatible with this study
* Severe infection in the past two months
* Immune disorder, or use of any medication that can alter immune system function
* A medical or mental health finding showing inability to go through the procedure
* Body mass index (BMI) greater than 29%
* Chronic back pain, sciatica, or a compression fracture of the spine
* Positive test results for viral infections: Hepatitis B, Hepatitis C, or HIV (AIDS)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Institute on Aging (NIA)

NIH

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Dan L. Longo, MD

Role: PRINCIPAL_INVESTIGATOR

National Institute on Aging (NIA)

Locations

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NIA Clinical Research Unit located at Harbor Hospital

Baltimore, Maryland, United States

Site Status

Countries

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United States

References

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Cashman J, Clark-Lewis I, Eaves A, Eaves C. Stromal-derived factor 1 inhibits the cycling of very primitive human hematopoietic cells in vitro and in NOD/SCID mice. Blood. 2002 Feb 1;99(3):792-9. doi: 10.1182/blood.v99.3.792.

Reference Type BACKGROUND
PMID: 11806978 (View on PubMed)

Exley MA, Tahir SM, Cheng O, Shaulov A, Joyce R, Avigan D, Sackstein R, Balk SP. A major fraction of human bone marrow lymphocytes are Th2-like CD1d-reactive T cells that can suppress mixed lymphocyte responses. J Immunol. 2001 Nov 15;167(10):5531-4. doi: 10.4049/jimmunol.167.10.5531.

Reference Type BACKGROUND
PMID: 11698421 (View on PubMed)

Johnson BS, Mueller L, Si J, Collins SJ. The cytokines IL-3 and GM-CSF regulate the transcriptional activity of retinoic acid receptors in different in vitro models of myeloid differentiation. Blood. 2002 Feb 1;99(3):746-53. doi: 10.1182/blood.v99.3.746.

Reference Type BACKGROUND
PMID: 11806973 (View on PubMed)

Other Identifiers

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AG0046

Identifier Type: -

Identifier Source: org_study_id