A Study of Carbon 13-based Deep Labelling of Bone Marrow Cells
NCT ID: NCT07057583
Last Updated: 2025-12-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ENROLLING_BY_INVITATION
40 participants
OBSERVATIONAL
2025-02-01
2027-12-31
Brief Summary
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Detailed Description
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I. Evaluate differences in the amount of extracellular uptake of glucose and amino acids (AAs) between pre-malignant clonal plasma cells (cPCs) and polyclonal plasma cells (pPCs).
OUTLINE: This is an observational study. Participants are assigned to 1 of 2 groups.
GROUP I: Patients undergo blood collection and bone marrow aspiration as part of their standard care and have their medical records reviewed on study.
GROUP II: Healthy volunteers undergo blood collection and bone marrow aspiration on study.
Conditions
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Study Design
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CASE_CONTROL
CROSS_SECTIONAL
Study Groups
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Observational Group I
Patients undergo blood collection and bone marrow aspiration as part of their standard care and have their medical records reviewed on study.
Non-Interventional Study
Non-interventional study
Observational Group II
Healthy volunteers undergo blood collection and bone marrow aspiration on study.
Non-Interventional Study
Non-interventional study
Interventions
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Non-Interventional Study
Non-interventional study
Eligibility Criteria
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Inclusion Criteria
* At least age 18 years or older
* Able to provide informed consent
* MGUS Cohort:
* International Myeloma Working Group (IMWG) criteria for the diagnosis of non-IgM MGUS
Exclusion Criteria
* Unable to provide consent
* Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) \>1
* Prior history of adverse events with conscious sedation
* Ongoing use of immunosuppressive medications
* All known pregnant and lactating women will be excluded
18 Years
ALL
Yes
Sponsors
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Mayo Clinic
OTHER
Responsible Party
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Principal Investigators
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Wilson I. Gonsalves, MD
Role: PRINCIPAL_INVESTIGATOR
Mayo Clinic in Rochester
Locations
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Mayo Clinic in Rochester
Rochester, Minnesota, United States
Countries
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Related Links
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Mayo Clinic Clinical Trials
Other Identifiers
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NCI-2025-01095
Identifier Type: REGISTRY
Identifier Source: secondary_id
24-003478
Identifier Type: OTHER
Identifier Source: secondary_id
HT9425-24-1-0619
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
24-003478
Identifier Type: -
Identifier Source: org_study_id