Impact of HIV and Its Treatment on Reverse Cholesterol Transport

NCT ID: NCT00168233

Last Updated: 2012-01-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

44 participants

Study Classification

OBSERVATIONAL

Study Start Date

2005-06-30

Study Completion Date

2011-03-31

Brief Summary

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To investigate the effect of treatment of HIV infection with highly active antiretroviral therapy on individual steps of reverse cholesterol transport, endothelial function and intima-media thickness in HIV patients.

Detailed Description

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Conditions

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HIV Infections

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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1

No antiretroviral therapy for 12 months

No interventions assigned to this group

2

Initiating ARV therapy with an NNRTI based regimen

No interventions assigned to this group

3

Initiating ARV therapy with a PI based regimen

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Male patients with HIV infection (3 groups of 50 patients each)
* HIV infected patients, naïve to ARV therapy and not likely to need to commence therapy for the duration of follow-up (12 months)
* HIV-infected patients, PI naïve, initiating therapy with PI-containing HAART (ARV naïve or NNRTI experienced changing to PI regimen)
* HIV-infected patients naïve to ARV therapy, initiating NNRTI-containing regimen

Exclusion Criteria

* Treatment with any form of lipid lowering drugs, including fish oils.
* Body Mass Index greater than 27.
Minimum Eligible Age

18 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No

Sponsors

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National Health and Medical Research Council, Australia

OTHER

Sponsor Role collaborator

The Alfred

OTHER

Sponsor Role lead

Responsible Party

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Jennifer Hoy

Professor Jennifer Hoy

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Dmitri Sviridov, Dr

Role: STUDY_DIRECTOR

Baker Heart Research Institute, Commercial Road, Melbourne

Jennifer Hoy, A/Prof

Role: PRINCIPAL_INVESTIGATOR

Alfred Hospital, Melbourne, Vic 3004

Locations

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Alfred Hospital and Baker Heart Research Institute

Melbourne, Victoria, Australia

Site Status

Countries

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Australia

Other Identifiers

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54/05

Identifier Type: -

Identifier Source: org_study_id

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