Bisphosphonate Therapy for Osteogenesis Imperfecta

NCT ID: NCT00159419

Last Updated: 2017-06-14

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE4
• Total Enrollment: 18 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 1999-08-31
• Study Completion Date: 2008-08-31

Brief Summary

The study is designed to evaluate the efficacy and safety of "Bisphosphonate Therapy for Osteogenesis Imperfecta (OI)." We, the researchers at Indiana University School of Medicine, are characterizing the changes effected by oral bisphosphonate therapy and comparing them to a regimen of intravenous bisphosphonate therapy in a group of children with OI and also in children with other disorders that result in low bone mass and fractures.

Detailed Description

The study is designed to evaluate the efficacy and safety of "Bisphosphonate Therapy for Osteogenesis Imperfecta (OI)." OI is an inherited disorder of collagen synthesis. Collagen is the major structural protein of the matrix of tendons, skin, and bones. Affected persons have low bone mineral density (and experience multiple fractures and progressive bony deformity). In its most severe form, the disorder is lethal in infancy. We plan to characterize the changes effected by oral bisphosphonate therapy and compare them to a regimen of intravenous bisphosphonate therapy in a group of children with OI.

Additionally, we have begun to treat patients with OI and other conditions of low bone mineralization for age who are not eligible for the standard protocol (too young, history of abdominal pain, etc.) with bisphosphonate. We also plan to screen the parents and siblings of our patients diagnosed with osteogenesis imperfecta, in order to determine if they also have osteoporosis.

Conditions

Osteogenesis Imperfecta; Osteoporosis; Paget Disease of Bone

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

Alendronate

1 mg/kg po qd rounded to nearest 10 or 20 mg dose

Group Type: ACTIVE_COMPARATOR

Alendronate

Intervention Type: DRUG

Pamidronate

3 mg/kg IV q4 months

Group Type: ACTIVE_COMPARATOR

Pamidronate

Intervention Type: DRUG

Interventions

Alendronate

Intervention Type: DRUG

Pamidronate

Intervention Type: DRUG

Other Intervention Names

fosamax

Eligibility Criteria

Inclusion Criteria

• Diagnosis of OI, as defined by genetic analysis revealing a defect of type I collagen, OR by bone mineral density (BMD) <2.5 standard deviations (SD) for age plus two of the following:

• Family history of OI
• Frequent fractures
• Blue sclerae
• Multiple wormian bones on skull x-ray
• Hearing disturbance
• Dentinogenesis imperfecta
• Age between 3 and 21 years at the start of the study period.
• Children must be able to swallow whole tablets
• Parents of children must be able to understand protocol and give informed consent.

Exclusion Criteria

• Therapy with bisphosphonates during the past 12 months.
• Other "non-traditional" therapy for OI in the last 6 months, such as growth hormone or anabolic steroids.
• Other chronic diseases besides OI that interfere with bone morphology or gastrointestinal absorption

• Minimum Eligible Age: 3 Years
• Maximum Eligible Age: 21 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Indiana University School of Medicine

OTHER

Sponsor Role: lead

Responsible Party

Linda DiMeglio, MD

MD

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Linda A DiMeglio, MD, MPH

Role: PRINCIPAL_INVESTIGATOR

Indiana University School of Medicine

Other Identifiers

9902-30

Identifier Type: -

Identifier Source: org_study_id