Study of Human Insulin Inhalation Powder in Patients With Type 1 Diabetes

NCT ID: NCT00127634

Last Updated: 2018-03-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

385 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-07-31

Study Completion Date

2008-05-31

Brief Summary

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This is a phase 3, open-label, randomized study to evaluate the safety and efficacy of the Lilly/Alkermes inhaled insulin system compared to injected pre-meal insulin in non-smoking patients with type 1 diabetes. Patients will be treated for 24 months with a 2-month follow-up period.

Detailed Description

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Conditions

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Diabetes Mellitus, Type 1

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Group Type EXPERIMENTAL

Human Insulin Inhalation Powder

Intervention Type DRUG

patient specific dose, inhaled, before meals, 24 months, up to 36 months

Insulin Glargine

Intervention Type DRUG

patient specific dose, injectable, as needed, 24 months up to 36 months

2

Group Type ACTIVE_COMPARATOR

Injectable Insulin

Intervention Type DRUG

patient specific dose, injectable, before meals, 24 months, up to 36 months.

Insulin Glargine

Intervention Type DRUG

patient specific dose, injectable, as needed, 24 months up to 36 months

Interventions

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Human Insulin Inhalation Powder

patient specific dose, inhaled, before meals, 24 months, up to 36 months

Intervention Type DRUG

Injectable Insulin

patient specific dose, injectable, before meals, 24 months, up to 36 months.

Intervention Type DRUG

Insulin Glargine

patient specific dose, injectable, as needed, 24 months up to 36 months

Intervention Type DRUG

Other Intervention Names

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LY041001

Eligibility Criteria

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Inclusion Criteria

* Type 1 diabetes
* Non smoker
* Normal lung function

Exclusion Criteria

* Significant pulmonary, hepatic, or renal disease
* Severe congestive heart failure
* Active malignancy
* Systemic glucocorticoid therapy
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Alkermes, Inc.

INDUSTRY

Sponsor Role collaborator

Eli Lilly and Company

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon-Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)

Role: STUDY_DIRECTOR

Eli Lilly and Company

Locations

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Sacramento, California, United States

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Walnut Creek, California, United States

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Aurora, Colorado, United States

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Denver, Colorado, United States

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Newark, Delaware, United States

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Hollywood, Florida, United States

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Jacksonville, Florida, United States

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Largo, Florida, United States

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New Port Richey, Florida, United States

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West Palm Beach, Florida, United States

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Atlanta, Georgia, United States

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Idaho Falls, Idaho, United States

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Chicago, Illinois, United States

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Springfield, Illinois, United States

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Indianapolis, Indiana, United States

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Louisville, Kentucky, United States

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Baltimore, Maryland, United States

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St Louis, Missouri, United States

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Omaha, Nebraska, United States

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North Plainfield, New Jersey, United States

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Flushing, New York, United States

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Lake Success, New York, United States

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New Hyde Park, New York, United States

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Staten Island, New York, United States

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Morehead City, North Carolina, United States

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Raleigh, North Carolina, United States

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Medford, Oregon, United States

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Downingtown, Pennsylvania, United States

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Sellersville, Pennsylvania, United States

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Sioux Falls, South Dakota, United States

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Dallas, Texas, United States

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Houston, Texas, United States

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San Antonio, Texas, United States

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Renton, Washington, United States

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Milwaukee, Wisconsin, United States

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Aalst, , Belgium

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Arlon, , Belgium

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Brussels, , Belgium

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Edegem, , Belgium

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Leuven, , Belgium

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Liège, , Belgium

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Winnipeg, Manitoba, Canada

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Corunna, Ontario, Canada

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Niagara Falls, Ontario, Canada

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Peterborough, Ontario, Canada

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Sarnia, Ontario, Canada

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Montreal, Quebec, Canada

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Zagreb, , Croatia

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Budapest, , Hungary

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Debrecen, , Hungary

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Eger, , Hungary

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Gyula, , Hungary

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Kecskemét, , Hungary

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Nyíregyháza, , Hungary

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Szeged, , Hungary

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Szolnok, , Hungary

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Bangalore, , India

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Kochi, , India

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Mumbai, , India

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New Dehli, , India

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Noida, , India

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Countries

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United States Belgium Canada Croatia Hungary India

References

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Garg SK, Mathieu C, Rais N, Gao H, Tobian JA, Gates JR, Ferguson JA, Webb DM, Berclaz PY. Two-year efficacy and safety of AIR inhaled insulin in patients with type 1 diabetes: An open-label randomized controlled trial. Diabetes Technol Ther. 2009 Sep;11 Suppl 2:S5-S16. doi: 10.1089/dia.2009.0040.

Reference Type DERIVED
PMID: 19772449 (View on PubMed)

Other Identifiers

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H7U-MC-IDAH

Identifier Type: -

Identifier Source: secondary_id

6120

Identifier Type: -

Identifier Source: org_study_id

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