A Study for Patients With Type 1 Diabetes Mellitus

NCT ID: NCT00447213

Last Updated: 2010-10-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2/PHASE3

Total Enrollment

70 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-04-30

Study Completion Date

2008-05-31

Brief Summary

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The purpose of the study is to compare the human insulin inhalation powder plus insulin glargine with injected insulin (regular human insulin or insulin lispro) plus insulin glargine on lowering the blood sugar level.

Detailed Description

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Conditions

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Diabetes Mellitus, Type 1

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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1

Group Type EXPERIMENTAL

Insulin glargine

Intervention Type DRUG

Patient specific, injected, daily, 24 weeks

Human Insulin Inhalation Powder

Intervention Type DRUG

patient specific dose, inhaled, before meals,12 weeks

Injectable Insulin

Intervention Type DRUG

Patient specific dose,injected, before meals, 12 weeks

2

Group Type EXPERIMENTAL

Insulin glargine

Intervention Type DRUG

Patient specific, injected, daily, 24 weeks

Human Insulin Inhalation Powder

Intervention Type DRUG

patient specific dose, inhaled, before meals,12 weeks

Injectable Insulin

Intervention Type DRUG

Patient specific dose,injected, before meals, 12 weeks

Interventions

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Insulin glargine

Patient specific, injected, daily, 24 weeks

Intervention Type DRUG

Human Insulin Inhalation Powder

patient specific dose, inhaled, before meals,12 weeks

Intervention Type DRUG

Injectable Insulin

Patient specific dose,injected, before meals, 12 weeks

Intervention Type DRUG

Other Intervention Names

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LY041001

Eligibility Criteria

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Inclusion Criteria

* Type 1 diabetes mellitus for at least 24 months
* Injecting insulin (insulin lispro, aspart or regular insulin, insulin lispro/aspart mixtures, or regular human insulin mixtures) in the last 24 months
* HbA1c equal or less than 11 %
* Nonsmokers, had not smoked for at least 6 months and agree not to smoke (cigars, cigarettes or pipes) or use smokeless tobacco for the duration of the study
* Satisfactory lung function results to meet the requirement of the study

Exclusion Criteria

* Previously received any form of inhaled insulin
* Require a daily total insulin dosage greater than 100 U
* Have a current or past history of asthma, chronic obstructive pulmonary disease or other clinically relevant lung disease
* History or presence of liver disease
* History or presence of kidney disease
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Alkermes, Inc.

INDUSTRY

Sponsor Role collaborator

Eli Lilly and Company

INDUSTRY

Sponsor Role lead

Responsible Party

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Eli Lilly

Principal Investigators

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Call 1-877-CTLILLY (1-277-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)

Role: STUDY_DIRECTOR

Eli Lilly and Company

Locations

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For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.

Kanagawa, , Japan

Site Status

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.

Tokyo, , Japan

Site Status

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.

Changhua, , Taiwan

Site Status

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.

Taipei, , Taiwan

Site Status

For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician.

Taoyuan District, , Taiwan

Site Status

Countries

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Japan Taiwan

References

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Hitoshi Ishii, Satoru Tsujii, Masami Tanaka, Miyuki Furuya, Tadao Iburi, Rei Ueda, Sakura Okuyama, Risa P. Hayes, Masato Okamura, Kazuya Iwamoto, Eisei Oda. Development of IDSQ-J and assessment of reproducibility adequacy. Tonyobyo. 2009;52(3):209-221.

Reference Type RESULT

Other Identifiers

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H7U-JE-IDBB

Identifier Type: -

Identifier Source: secondary_id

10299

Identifier Type: -

Identifier Source: org_study_id