Changes in Cardiovascular Hemodynamics During Peritoneal Dialysis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

15 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-01-31

Study Completion Date

2010-01-31

Brief Summary

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During peritoneal dialysis, water is removed from the body. This sometimes occurs at rates of up to 500 ml/h. During shifts with dialysate with high glucose content, an increase in blood pressure has been described. The effect upon central hemodynamics is unknown. The researchers are investigating the effects of low and high glucose dialysate and icodextrin on cardiac output, stroke volume, pulse rate and blood pressure. The researchers have hypothesized that the effects seen are induced by vasopressin.

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Detailed Description

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Conditions

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Peritoneal Dialysis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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Icodextrin (dialysate)

2 liter of extraneal are given with one fill for 4 hours.

Intervention Type DRUG

Physioneal (dialysate) 1.36% and 2.27%

2 liter of Physioneal of 1.36% or 3.86% are given with one fill for 4 hours one two different days.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Peritoneal dialysis patients

Exclusion Criteria

* Insulin dependent diabetes mellitus
* AV-fistula, cardial arrhythmia persistence, or severe cardiac and lung disease
* Recent infectious disease
* Severe psychiatric disease
* Hypersensitivity to icodextrin

Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No