A Study of Albuferon and Ribavirin in Interferon Naive Subjects With Chronic Hepatitis C Genotype 1

NCT ID: NCT00115908

Last Updated: 2013-11-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

458 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-05-31

Study Completion Date

2007-05-31

Brief Summary

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The purpose of the study is to evaluate the efficacy and safety of Albuferon in combination with ribavirin in interferon (IFN) alfa treatment-naïve subjects with chronic hepatitis C genotype 1. The study will randomize subjects to 1 of 4 treatment groups including 3 different Albuferon groups or to the active control group, peginterferon alfa-2a (PEGASYS, PEG-IFNalfa-2a). All subjects will also receive oral daily ribavirin.

Detailed Description

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Conditions

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Hepatitis C, Chronic

Keywords

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Hepatitis C

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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Albuferon

Intervention Type DRUG

Ribavirin

Intervention Type DRUG

PEG-IFNalfa2a

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Interferon treatment naive subjects with chronic hepatitis C, HCV genotype 1.
* Compensated liver disease

Exclusion Criteria

* Pregnant or lactating female or males with a pregnant partner.
* A positive test for serum antibodies to the human immunodeficiency virus (HIV-1) or serum hepatitis B virus surface antigen (HBsAg).
* A history of moderate, severe or uncontrolled psychiatric disease.
* A history of immunologically mediated disease, seizure disorder, chronic cardiac disease, chronic pulmonary disease, hemoglobinopathy, coagulopathy, or malignancy.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Human Genome Sciences Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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GSK Clinical Trials

Role: STUDY_DIRECTOR

GlaxoSmithKline

Locations

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Royal Prince Alfred Hospital

Camperdown, New South Wales, Australia

Site Status

Concord Repatriation General Hospital

Concord, New South Wales, Australia

Site Status

John Hunter Hospital

New Lambton Heights, New South Wales, Australia

Site Status

Westmead Hospital

Westmead, New South Wales, Australia

Site Status

Princess Alexandra Hospital

Brisbane, Queensland, Australia

Site Status

Royal Brisbane Hospital

Herston, Queensland, Australia

Site Status

Royal Adelaide Hospital

Adelaide, South Australia, Australia

Site Status

Monash Medical Centre

Clayton, Victoria, Australia

Site Status

St. Vincents Hospital

East Melbourne, Victoria, Australia

Site Status

Western Hospital

Footscray, Victoria, Australia

Site Status

Austin Health

Heidelberg, Victoria, Australia

Site Status

The Alfred

Melbourne, Victoria, Australia

Site Status

Royal Melbourne Hospital

Melbourne, Victoria, Australia

Site Status

Fremantle Hospital

Fremantle, Western Australia, Australia

Site Status

Sir Charles Gairdner Hospital

Nedlands, Western Australia, Australia

Site Status

Royal Perth Hospital

Perth, Western Australia, Australia

Site Status

University of Calgary

Calgary, Alberta, Canada

Site Status

University of Alberta

Edmonton, Alberta, Canada

Site Status

University of Alberta- Liver Unit

Edmonton, Alberta, Canada

Site Status

University of British Columbia

Vancouver, British Columbia, Canada

Site Status

University of Manitoba

Winnipeg, Manitoba, Canada

Site Status

Dalhousie University

Halifax, Nova Scotia, Canada

Site Status

McMaster Clinic - Hamilton General Hospital

Hamilton, Ontario, Canada

Site Status

University of Western Ontario

London, Ontario, Canada

Site Status

Ottawa Civic Hospital

Ottawa, Ontario, Canada

Site Status

Toronto General Hospital

Toronto, Ontario, Canada

Site Status

Toronto Western Hospital

Toronto, Ontario, Canada

Site Status

University of Saskatchewan

Saskatoon, Saskatchewan, Canada

Site Status

FN Bohunice

Brno, , Czechia

Site Status

Klinika infekcnich nemoci

Hradec Králové, , Czechia

Site Status

Nemocnice s poliklinikou Melnik

Mělník, , Czechia

Site Status

Slezska nemocnice

Opava, , Czechia

Site Status

Vseobecna fakultni nemocnice

Prague, , Czechia

Site Status

Nuselska poliklinika - Remedis

Prague, , Czechia

Site Status

Fakultni Thomayerova nemocnice

Prague, , Czechia

Site Status

Ambulance pro interni a infekcni nemoci

Ústí nad Labem, , Czechia

Site Status

University of Angers, CHU Angers

Angers, , France

Site Status

University of Clichy, Hopital Beaujon

Clichy, , France

Site Status

University of Creteil, Hopital Henri Mondor

Créteil, , France

Site Status

University of Grenoble, Hopital Nord

Grenoble, , France

Site Status

University of Lille, Hopital Claude Huriez

Lille, , France

Site Status

University of Lyon, Hopital de l'Hotel Dieu

Lyon, , France

Site Status

University of Marseille, Hopital Saint Joseph

Marseille, , France

Site Status

University of Nice, Hopital de l'Archet

Nice, , France

Site Status

University of Orleans, Hopital de la Source

Orléans, , France

Site Status

University of Paris, Hopital Saint-Antoine

Paris, , France

Site Status

University of Paris, Hopital Pitie-Salpetriere

Paris, , France

Site Status

University of Paris, Hopital Necker

Paris, , France

Site Status

Hopital Haut-Leveque

Pessac, , France

Site Status

University of Toulouse, Clinique Dieulafoy

Toulouse, , France

Site Status

Hopital de Brabois

Vandœuvre-lès-Nancy, , France

Site Status

University of Berlin, Charite Campus Virchow Klinikum

Berlin, , Germany

Site Status

University of Bochum, Kliniken Bergmannsheil

Bochum, , Germany

Site Status

University of Duesseldorf

Düsseldorf, , Germany

Site Status

University of Essen

Essen, , Germany

Site Status

University of Frankfurt

Frankfurt, , Germany

Site Status

University of Freiburg

Freiburg im Breisgau, , Germany

Site Status

University of Hamburg, Hospital Hamburg Eppendorf

Hamburg, , Germany

Site Status

University of Hannover

Hanover, , Germany

Site Status

University of Heidelberg

Heidelberg, , Germany

Site Status

University of Saarland

Homburg, , Germany

Site Status

University of Kiel

Kiel, , Germany

Site Status

University of Leipzig

Leipzig, , Germany

Site Status

University of Mainz

Mainz, , Germany

Site Status

University of Tuebingen

Tübingen, , Germany

Site Status

B´nai-Zion Medical Center

Haifa, , Israel

Site Status

Rambam Medical Center

Haifa, , Israel

Site Status

Hadassah Medical Organization

Jerusalem, , Israel

Site Status

Holy Family Hospital

Nazareth, , Israel

Site Status

Rabin Medical Center, Beilinson Campus

Petah Tikva, , Israel

Site Status

Tel Aviv Sourasky Medical Center

Tel Aviv, , Israel

Site Status

Oddzial Chorob Watroby

Bialystok, , Poland

Site Status

Katedra i Klinika Chorob Zakaznych i Hepatologii

Bydgoszcz, , Poland

Site Status

Katedra i Oddzial Kliniczny Chorob Zakaznych

Chorzów, , Poland

Site Status

Wojewodzki Szpital Zespolony

Kielce, , Poland

Site Status

Szpital Uniwersytecki w Krakowie

Krakow, , Poland

Site Status

Klinika Obserwacyjno Zakazna

Lodz, , Poland

Site Status

Oddzial Zakazny

Poznan, , Poland

Site Status

Katedra i Klinika Chorob Zakaznych

Szczecin, , Poland

Site Status

I Oddzial Dzienny SPZOZ

Warsaw, , Poland

Site Status

Klinika Hepatologii i Nabytych Niedoborow Immunologicznych

Warsaw, , Poland

Site Status

Katedra i Klinika Chorob Zakaznych

Wroclaw, , Poland

Site Status

Spitalul Clinic Colentina

Bucharest, , Romania

Site Status

Institutul Clinic Fundeni

Bucharest, , Romania

Site Status

Spitalul de Boli Infectioase si Tropicale "Dr. Victor Babes"

Bucharest, , Romania

Site Status

Spitalul Clinic de Adulti Cluj-Napoca

Cluj-Napoca, , Romania

Site Status

Institutul de Gastroenterologie si Hepatologie

Iași, , Romania

Site Status

Countries

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Australia Canada Czechia France Germany Israel Poland Romania

References

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Neumann AU, Pianko S, Zeuzem S, Yoshida EM, Benhamou Y, Mishan M, McHutchison JG, Pulkstenis E, Mani Subramanian G. Positive and negative prediction of sustained virologic response at weeks 2 and 4 of treatment with albinterferon alfa-2b or peginterferon alfa-2a in treatment-naive patients with genotype 1, chronic hepatitis C. J Hepatol. 2009 Jul;51(1):21-8. doi: 10.1016/j.jhep.2009.01.017. Epub 2009 Mar 11.

Reference Type DERIVED
PMID: 19447518 (View on PubMed)

Zeuzem S, Yoshida EM, Benhamou Y, Pianko S, Bain VG, Shouval D, Flisiak R, Rehak V, Grigorescu M, Kaita K, Cronin PW, Pulkstenis E, Subramanian GM, McHutchison JG. Albinterferon alfa-2b dosed every two or four weeks in interferon-naive patients with genotype 1 chronic hepatitis C. Hepatology. 2008 Aug;48(2):407-17. doi: 10.1002/hep.22403.

Reference Type DERIVED
PMID: 18666223 (View on PubMed)

Other Identifiers

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ALFR-HC-04

Identifier Type: -

Identifier Source: org_study_id