Safety Study of XP12B in Women With Menorrhagia

NCT ID: NCT00113568

Last Updated: 2010-06-15

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

784 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-06-30

Study Completion Date

2009-05-31

Brief Summary

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The purpose of this study is to evaluate the safety of XP12B in women with heavy menstrual bleeding associated with menorrhagia.

Detailed Description

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Conditions

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Menorrhagia Heavy Menstrual Bleeding

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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XP12B (tranexamic acid tablets)

Group Type EXPERIMENTAL

Tranexamic acid tablets (XP12B)

Intervention Type DRUG

Two 650 mg tranexamic acid tablets (XP12B) taken 3 times daily (3900 mg/Day) for a maximum of 5 days during monthly menstruation

Interventions

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Tranexamic acid tablets (XP12B)

Two 650 mg tranexamic acid tablets (XP12B) taken 3 times daily (3900 mg/Day) for a maximum of 5 days during monthly menstruation

Intervention Type DRUG

Other Intervention Names

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Lysteda XP12B tranexamic acid tablets XP12B-MR

Eligibility Criteria

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Inclusion Criteria

* Women with menorrhagia
* 18-49 years of age
* Regularly occuring menstrual periods

Exclusion Criteria

* History or presence of clinically significant disease or abnormalities that might confound the study
* History of bilateral oophorectomy or hysterectomy
Minimum Eligible Age

18 Years

Maximum Eligible Age

49 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Ferring Pharmaceuticals

INDUSTRY

Sponsor Role lead

Responsible Party

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Ferring Pharmaceuticals

Principal Investigators

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Clinical Development Support

Role: STUDY_DIRECTOR

Ferring Pharmaceuticals

Locations

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Investigative Site

Birmingham, Alabama, United States

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Mobile, Alabama, United States

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Montgomery, Alabama, United States

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Phoenix, Arizona, United States

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Phoenix, Arizona, United States

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Jonesboro, Arkansas, United States

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Little Rock, Arkansas, United States

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San Diego, California, United States

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San Diego, California, United States

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Colorado Springs, Colorado, United States

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Denver, Colorado, United States

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Fort Myers, Florida, United States

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Miami, Florida, United States

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New Port Richey, Florida, United States

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Ocala, Florida, United States

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Pinellas Park, Florida, United States

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Venice, Florida, United States

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West Palm Beach, Florida, United States

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West Palm Beach, Florida, United States

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Alpharetta, Georgia, United States

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Roswell, Georgia, United States

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Savannah, Georgia, United States

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Savannah, Georgia, United States

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Boise, Idaho, United States

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Champaign, Illinois, United States

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Evansville, Indiana, United States

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Indianapolis, Indiana, United States

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South Bend, Indiana, United States

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Overland Park, Kansas, United States

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Lexington, Kentucky, United States

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Louisville, Kentucky, United States

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Shreveport, Louisiana, United States

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Portage, Michigan, United States

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Chaska, Minnesota, United States

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St Louis, Missouri, United States

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St Louis, Missouri, United States

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St Louis, Missouri, United States

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Billings, Montana, United States

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Omaha, Nebraska, United States

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Las Vegas, Nevada, United States

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Las Vegas, Nevada, United States

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Moorestown, New Jersey, United States

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Albuquerque, New Mexico, United States

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Johnson City, New York, United States

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Charlotte, North Carolina, United States

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Durham, North Carolina, United States

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Winston-Salem, North Carolina, United States

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Cincinnati, Ohio, United States

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Cincinnati, Ohio, United States

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Toledo, Ohio, United States

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Philadelphia, Pennsylvania, United States

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Wexford, Pennsylvania, United States

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Columbia, South Carolina, United States

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Nashville, Tennessee, United States

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Nashville, Tennessee, United States

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Houston, Texas, United States

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Norfolk, Virginia, United States

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Seattle, Washington, United States

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Tacoma, Washington, United States

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Countries

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United States

References

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Muse K, Lukes AS, Gersten J, Waldbaum A, Mabey RG, Trott E. Long-term evaluation of safety and health-related quality of life in women with heavy menstrual bleeding treated with oral tranexamic acid. Womens Health (Lond). 2011 Nov;7(6):699-707. doi: 10.2217/whe.11.65. Epub 2011 Aug 25.

Reference Type DERIVED
PMID: 21867401 (View on PubMed)

Bushnell DM, Martin ML, Moore KA, Richter HE, Rubin A, Patrick DL. Menorrhagia Impact Questionnaire: assessing the influence of heavy menstrual bleeding on quality of life. Curr Med Res Opin. 2010 Dec;26(12):2745-55. doi: 10.1185/03007995.2010.532200. Epub 2010 Nov 3.

Reference Type DERIVED
PMID: 21043553 (View on PubMed)

Other Identifiers

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XP12B-MR-302

Identifier Type: -

Identifier Source: org_study_id

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