Treatment Protocol for the Use of Sorafenib in Patients With Advanced Renal Cell Carcinoma

NCT ID: NCT00111020

Last Updated: 2014-08-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

2567 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-06-30

Study Completion Date

2008-10-31

Brief Summary

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This treatment protocol allows doctors to treat advanced kidney cancer with an investigational drug called sorafenib, BAY43-9006, which is being studied in clinical trials for kidney cancer and other kinds of cancer. This treatment protocol is not a clinical trial in which sorafenib is compared to another equal treatment. All patients in this protocol will be treated with sorafenib. In addition, data from the patients who participate in this protocol will provide additional information about the drug.

Detailed Description

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Conditions

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Carcinoma, Renal Cell

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Arm 1

Group Type EXPERIMENTAL

Sorafenib (Nexavar, BAY43-9006)

Intervention Type DRUG

Multi kinase inhibitor: 400 mg of Sorafenib, orally, twice a day, on a continuous basis as a single agent for the treatment of advanced RCC

Interventions

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Sorafenib (Nexavar, BAY43-9006)

Multi kinase inhibitor: 400 mg of Sorafenib, orally, twice a day, on a continuous basis as a single agent for the treatment of advanced RCC

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients with advanced (unresectable, recurrent or metastatic) RCC
* Patients reasonably likely to benefit from treatment with sorafenib as a single agent therapy
* Patients with an ECOG performance status of 0-2
* Patients who will not require other systemic anticancer therapy (except for bisphosphonates) while taking sorafenib
* Patients with vascular diseases such as wet macular degeneration, vasculitis, or new peptic ulcer, may be enrolled but require close monitoring in accordance with established medical practice

Exclusion Criteria

* Patients who are currently enrolled in, are eligible for, or have access to, any other sorafenib clinical trial
* Patients who have participated in any other sorafenib trial
* Patients who have had prior therapy with investigational agent(s) within the last four weeks prior to study entry
* Life expectancy of less than two months
* Patients with cardiac arrhythmias greater than grade 1 NCI CTCAE, Version 3.0
* Patients with active coronary artery disease or ischemia
* Patients with Child-Pugh class C hepatic impairment
* Patients with severe renal impairment or who require dialysis
* Patients with active uncontrolled hypertension
* Patients with recent or active bleeding diathesis
Minimum Eligible Age

15 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Bayer

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Bayer Study Director

Role: STUDY_DIRECTOR

Bayer

Locations

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Bessemer, Alabama, United States

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Cullman, Alabama, United States

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Mobile, Alabama, United States

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Anchorage, Alaska, United States

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Glendale, Arizona, United States

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Scottsdale, Arizona, United States

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Tucson, Arizona, United States

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Conway, Arkansas, United States

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Hot Springs, Arkansas, United States

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Little Rock, Arkansas, United States

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Pine Bluff, Arkansas, United States

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Springdale, Arkansas, United States

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Bakersfield, California, United States

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Beverly, California, United States

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Concord, California, United States

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Duarte, California, United States

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Fountain Valley, California, United States

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Glendale, California, United States

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Highland, California, United States

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La Jolla, California, United States

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La Jolla, California, United States

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Loma Linda, California, United States

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Long Beach, California, United States

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Los Angeles, California, United States

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Los Angeles, California, United States

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Los Angeles, California, United States

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Los Angeles, California, United States

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Newport Beach, California, United States

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Orange, California, United States

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Rancho Mirage, California, United States

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Sacramento, California, United States

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Salinas, California, United States

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San Diego, California, United States

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San Francisco, California, United States

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Stanford, California, United States

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Sunnyvale, California, United States

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Vallejo, California, United States

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Aurora, Colorado, United States

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Colorado Springs, Colorado, United States

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Denver, Colorado, United States

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Denver, Colorado, United States

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Glenwood Springs, Colorado, United States

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Lafayette, Colorado, United States

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Loveland, Colorado, United States

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Greenwich, Connecticut, United States

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Hartford, Connecticut, United States

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Middletown, Connecticut, United States

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New Britain, Connecticut, United States

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New Haven, Connecticut, United States

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Norwich, Connecticut, United States

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Southington, Connecticut, United States

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Stamford, Connecticut, United States

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Trumbull, Connecticut, United States

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Boca Raton, Florida, United States

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Daytona Beach, Florida, United States

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Fort Lauderdale, Florida, United States

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Fort Myers, Florida, United States

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Gainesville, Florida, United States

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Hialeah, Florida, United States

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Jacksonville, Florida, United States

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Lakeland, Florida, United States

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Melbourne, Florida, United States

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Miami, Florida, United States

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Miami Beach, Florida, United States

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Ocala, Florida, United States

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Ocoee, Florida, United States

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Orlando, Florida, United States

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Ormond Beach, Florida, United States

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Panama City, Florida, United States

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Pensacola, Florida, United States

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Pensacola, Florida, United States

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St. Petersburg, Florida, United States

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Stuart, Florida, United States

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Tampa, Florida, United States

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Weston, Florida, United States

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Albany, Georgia, United States

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Atlanta, Georgia, United States

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Atlanta, Georgia, United States

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Augusta, Georgia, United States

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Columbus, Georgia, United States

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Macon, Georgia, United States

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Tamc, Hawaii, United States

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Coeur d'Alene, Idaho, United States

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Chicago, Illinois, United States

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Chicago, Illinois, United States

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Decatur, Illinois, United States

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Harvey, Illinois, United States

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Joliet, Illinois, United States

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Joliet, Illinois, United States

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Niles, Illinois, United States

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Peoria, Illinois, United States

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Springfield, Illinois, United States

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Urbana, Illinois, United States

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Beech Grove, Indiana, United States

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Evansville, Indiana, United States

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Fishers, Indiana, United States

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Goshen, Indiana, United States

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Indianapolis, Indiana, United States

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Indianapolis, Indiana, United States

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Kokomo, Indiana, United States

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La Porte, Indiana, United States

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South Bend, Indiana, United States

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Valparaiso, Indiana, United States

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Ames, Iowa, United States

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Cedar Rapids, Iowa, United States

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Council Bluffs, Iowa, United States

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Des Moines, Iowa, United States

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Dubuqe, Iowa, United States

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Sioux City, Iowa, United States

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Hutchinson, Kansas, United States

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Lawrence, Kansas, United States

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Olathe, Kansas, United States

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Overland Park, Kansas, United States

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Wichita, Kansas, United States

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Louisville, Kentucky, United States

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Louisville, Kentucky, United States

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Louisville, Kentucky, United States

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Louisville, Kentucky, United States

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Baton Rouge, Louisiana, United States

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Houma, Louisiana, United States

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Lafayette, Louisiana, United States

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Metairie, Louisiana, United States

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Shreveport, Louisiana, United States

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Bangor, Maine, United States

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Scarborough, Maine, United States

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Annapolis, Maryland, United States

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Baltimore, Maryland, United States

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Bethesda, Maryland, United States

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Chevy Chase, Maryland, United States

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Clinton, Maryland, United States

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Rockville, Maryland, United States

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Boston, Massachusetts, United States

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Jamaica Plain, Massachusetts, United States

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Milford, Massachusetts, United States

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Quincy, Massachusetts, United States

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Springfield, Massachusetts, United States

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Springfield, Massachusetts, United States

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Ann Arbor, Michigan, United States

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Clinton Township, Michigan, United States

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Detroit, Michigan, United States

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Detroit, Michigan, United States

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Grand Rapids, Michigan, United States

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Marquette, Michigan, United States

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Mount Clemens, Michigan, United States

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Muskegon, Michigan, United States

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Duluth, Minnesota, United States

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Minneapolis, Minnesota, United States

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Saint Louis Park, Minnesota, United States

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Saint Louis Park, Minnesota, United States

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Willmar, Minnesota, United States

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Kansas City, Missouri, United States

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Saint Joseph, Missouri, United States

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Springfield, Missouri, United States

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St Louis, Missouri, United States

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St Louis, Missouri, United States

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St Louis, Missouri, United States

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Missoula, Montana, United States

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Lincoln, Nebraska, United States

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Lincoln, Nebraska, United States

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North Platte, Nebraska, United States

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Omaha, Nebraska, United States

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Omaha, Nebraska, United States

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Omaha, Nebraska, United States

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Las Vegas, Nevada, United States

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Las Vegas, Nevada, United States

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Lebanon, New Hampshire, United States

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Portsmouth, New Hampshire, United States

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Belleville, New Jersey, United States

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East Orange, New Jersey, United States

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Hackensack, New Jersey, United States

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Long Branch, New Jersey, United States

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Montclair, New Jersey, United States

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Morristown, New Jersey, United States

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Cooperstown, New York, United States

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Dunkirk, New York, United States

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Fresh Meadows, New York, United States

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Glens Falls, New York, United States

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Jamaica, New York, United States

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Johnson City, New York, United States

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Latham, New York, United States

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Mineola, New York, United States

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Mount Kisco, New York, United States

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New York, New York, United States

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New York, New York, United States

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New York, New York, United States

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Poughkeepsie, New York, United States

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Rochester, New York, United States

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Setauket, New York, United States

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Stony Brook, New York, United States

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The Bronx, New York, United States

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The Bronx, New York, United States

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Utica, New York, United States

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Williamsville, New York, United States

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Burlington, North Carolina, United States

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Chapel Hill, North Carolina, United States

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Charlotte, North Carolina, United States

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Charlotte, North Carolina, United States

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Greenville, North Carolina, United States

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Hickory, North Carolina, United States

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Kinston, North Carolina, United States

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Pollocksville, North Carolina, United States

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Bismarck, North Dakota, United States

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Fargo, North Dakota, United States

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Fargo, North Dakota, United States

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Barberton, Ohio, United States

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Canton, Ohio, United States

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Canton, Ohio, United States

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Cincinnati, Ohio, United States

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Cleveland, Ohio, United States

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Columbus, Ohio, United States

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Columbus, Ohio, United States

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Columbus, Ohio, United States

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Dayton, Ohio, United States

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Mayfield Heights, Ohio, United States

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Middletown, Ohio, United States

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Lawton, Oklahoma, United States

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Tulsa, Oklahoma, United States

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Bend, Oregon, United States

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Medford, Oregon, United States

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Portland, Oregon, United States

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Allentown, Pennsylvania, United States

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Bethlehem, Pennsylvania, United States

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Dunmore, Pennsylvania, United States

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East Stroudsburg, Pennsylvania, United States

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Harrisburg, Pennsylvania, United States

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Hermitage, Pennsylvania, United States

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Kittanning, Pennsylvania, United States

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Lancaster, Pennsylvania, United States

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Lemoyne, Pennsylvania, United States

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Monongahela, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Pottsville, Pennsylvania, United States

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State College, Pennsylvania, United States

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Wynnewood, Pennsylvania, United States

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York, Pennsylvania, United States

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Cranston, Rhode Island, United States

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Charleston, South Carolina, United States

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Charleston, South Carolina, United States

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Columbia, South Carolina, United States

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Florence, South Carolina, United States

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North Charleston, South Carolina, United States

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Sioux Falls, South Dakota, United States

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Clarksville, Tennessee, United States

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Memphis, Tennessee, United States

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Memphis, Tennessee, United States

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Memphis, Tennessee, United States

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Nashville, Tennessee, United States

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Amarillo, Texas, United States

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Arlington, Texas, United States

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Austin, Texas, United States

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Austin, Texas, United States

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Austin, Texas, United States

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Dallas, Texas, United States

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Dallas, Texas, United States

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Dallas, Texas, United States

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Fort Worth, Texas, United States

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Houston, Texas, United States

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Midland, Texas, United States

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San Antonio, Texas, United States

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San Antonio, Texas, United States

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San Antonio, Texas, United States

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Temple, Texas, United States

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Tyler, Texas, United States

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Tyler, Texas, United States

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Ogden, Utah, United States

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Salt Lake City, Utah, United States

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Bennington, Vermont, United States

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Charlottesville, Virginia, United States

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Fairfax, Virginia, United States

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Lynchburg, Virginia, United States

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Norfolk, Virginia, United States

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Richmond, Virginia, United States

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Richmond, Virginia, United States

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Richmond, Virginia, United States

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Richmond, Virginia, United States

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Richmond, Virginia, United States

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Lacey, Washington, United States

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Seattle, Washington, United States

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Seattle, Washington, United States

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Tacoma, Washington, United States

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Vancouver, Washington, United States

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Yakima, Washington, United States

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Charleston, West Virginia, United States

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Huntington, West Virginia, United States

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Morgantown, West Virginia, United States

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Glendale, Wisconsin, United States

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Green Bay, Wisconsin, United States

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Madison, Wisconsin, United States

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Marshfield, Wisconsin, United States

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Milwaukee, Wisconsin, United States

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Milwaukee, Wisconsin, United States

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Wausau, Wisconsin, United States

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Edmonton, Alberta, Canada

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Winnipeg, Manitoba, Canada

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Halifax, Nova Scotia, Canada

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Hamilton, Ontario, Canada

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London, Ontario, Canada

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Toronto, Ontario, Canada

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Toronto, Ontario, Canada

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Montreal, Quebec, Canada

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Countries

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United States Canada

References

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Stadler WM, Figlin RA, McDermott DF, Dutcher JP, Knox JJ, Miller WH Jr, Hainsworth JD, Henderson CA, George JR, Hajdenberg J, Kindwall-Keller TL, Ernstoff MS, Drabkin HA, Curti BD, Chu L, Ryan CW, Hotte SJ, Xia C, Cupit L, Bukowski RM; ARCCS Study Investigators. Safety and efficacy results of the advanced renal cell carcinoma sorafenib expanded access program in North America. Cancer. 2010 Mar 1;116(5):1272-80. doi: 10.1002/cncr.24864.

Reference Type DERIVED
PMID: 20082451 (View on PubMed)

Other Identifiers

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11868

Identifier Type: -

Identifier Source: org_study_id

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