A Study of GT267-004 Versus Vancomycin and GT267-004 Versus Metronidazole in Patients With C.Difficile - Associated Diarrhea

NCT ID: NCT00106509

Last Updated: 2015-03-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

520 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-03-31

Study Completion Date

2007-02-28

Brief Summary

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Approximately 520 patients will be entered into this study taking place throughout the US and Canada. This study aims to determine if an investigational drug is safe and effective for treating symptoms of C. difficile-associated diarrhea (CDAD) and lowering the risk of repeat episodes of CDAD. The investigational drug will be evaluated in comparison to current standard antibiotic treatment, so all patients will receive active medication. All study related care is provided including doctor visits, physical exams, laboratory tests and study medication. Total length of participation is approximately 6 weeks.

Detailed Description

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Conditions

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Clostridium Enterocolitis Pseudomembranous Colitis

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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tolevamer potassium-sodium (GT267-004)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* 18 years of age
* The presence of CDAD at the time of enrollment with no other likely etiology for the diarrhea
* Less than or equal to 48 hours of treatment with metronidazole, vancomycin or other antibacterial therapy specific for CDAD
* Baseline serum potassium \> 3.0 mmol (meq)/L
* Patient considered sufficiently stable clinically to likely complete a 6 week study period
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Genzyme, a Sanofi Company

INDUSTRY

Sponsor Role lead

Responsible Party

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Genzyme Corporation

Principal Investigators

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Medical Monitor

Role: STUDY_DIRECTOR

Genzyme, a Sanofi Company

Locations

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Phoenix, Arizona, United States

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Phoenix, Arizona, United States

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Rogers, Arkansas, United States

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Burbank, California, United States

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Los Angeles, California, United States

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Los Angeles, California, United States

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Los Angeles, California, United States

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Modesto, California, United States

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Newport Beach, California, United States

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Sacramento, California, United States

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San Diego, California, United States

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Denver, Colorado, United States

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Denver, Colorado, United States

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Denver, Colorado, United States

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Denver, Colorado, United States

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Newark, Delaware, United States

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Bay Pines, Florida, United States

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Brandon, Florida, United States

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Brooksville, Florida, United States

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Jacksonville, Florida, United States

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Tampa, Florida, United States

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Zephyrhills, Florida, United States

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Atlanta, Georgia, United States

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Fort Eisenhower, Georgia, United States

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Savannah, Georgia, United States

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Honolulu, Hawaii, United States

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Chicago, Illinois, United States

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Decatur, Illinois, United States

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Hines, Illinois, United States

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Maywood, Illinois, United States

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North Chicago, Illinois, United States

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Anderson, Indiana, United States

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Indianapolis, Indiana, United States

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Lafayette, Indiana, United States

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Muncie, Indiana, United States

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Clive, Iowa, United States

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Des Moines, Iowa, United States

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Des Moines, Iowa, United States

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Dubuque, Iowa, United States

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Iowa City, Iowa, United States

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Bowling Green, Kentucky, United States

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Louisville, Kentucky, United States

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Louisville, Kentucky, United States

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New Orleans, Louisiana, United States

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New Orleans, Louisiana, United States

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Baltimore, Maryland, United States

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Hagerstown, Maryland, United States

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Boston, Massachusetts, United States

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Boston, Massachusetts, United States

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Worcester, Massachusetts, United States

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Worcester, Massachusetts, United States

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Detroit, Michigan, United States

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Detroit, Michigan, United States

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Muskegon, Michigan, United States

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Rochester, Minnesota, United States

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Ocean Springs, Mississippi, United States

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Everton, Missouri, United States

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Kansas City, Missouri, United States

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St Louis, Missouri, United States

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Butte, Montana, United States

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Missoula, Montana, United States

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Lebanon, New Hampshire, United States

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Cedar Knolls, New Jersey, United States

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Neptune City, New Jersey, United States

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Newark, New Jersey, United States

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Trenton, New Jersey, United States

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Albany, New York, United States

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New Hyde Park, New York, United States

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New York, New York, United States

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Syracuse, New York, United States

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Asheville, North Carolina, United States

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Greenville, North Carolina, United States

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Raleigh, North Carolina, United States

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Fargo, North Dakota, United States

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Akron, Ohio, United States

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Centerville, Ohio, United States

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Toledo, Ohio, United States

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Allentown, Pennsylvania, United States

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Doylestown, Pennsylvania, United States

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Lancaster, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Philadelphia, Pennsylvania, United States

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Pittsburgh, Pennsylvania, United States

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Pittsburgh, Pennsylvania, United States

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Charleston, South Carolina, United States

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Greenville, South Carolina, United States

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Rapid City, South Dakota, United States

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Hermitage, Tennessee, United States

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Houston, Texas, United States

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Tyler, Texas, United States

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Burlington, Vermont, United States

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Danville, Virginia, United States

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Richmond, Virginia, United States

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Richmond, Virginia, United States

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Winchester, Virginia, United States

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Tacoma, Washington, United States

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Eau Claire, Wisconsin, United States

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Marshfield, Wisconsin, United States

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Milwaukee, Wisconsin, United States

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Calgary, Alberta, Canada

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Edmonton, Alberta, Canada

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Kelowna, British Columbia, Canada

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Kelowna, British Columbia, Canada

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Vancouver, British Columbia, Canada

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Victoria, British Columbia, Canada

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Winnipeg, Manitoba, Canada

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Winnipeg, Manitoba, Canada

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Moncton, New Brunswick, Canada

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Saint John, New Brunswick, Canada

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Halifax, Nova Scotia, Canada

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Ajax, Ontario, Canada

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Guelph, Ontario, Canada

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Hamilton, Ontario, Canada

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Kingston, Ontario, Canada

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London, Ontario, Canada

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Ottawa, Ontario, Canada

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Peterborough, Ontario, Canada

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Scarborough Village, Ontario, Canada

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Thunder Bay, Ontario, Canada

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Toronto, Ontario, Canada

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Toronto, Ontario, Canada

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Toronto, Ontario, Canada

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Toronto, Ontario, Canada

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Toronto, Ontario, Canada

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Windsor, Ontario, Canada

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Windsor, Ontario, Canada

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Chicoutimi, Quebec, Canada

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Green Field Park, Quebec, Canada

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Lévis, Quebec, Canada

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Montreal, Quebec, Canada

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Montreal, Quebec, Canada

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Montreal, Quebec, Canada

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Québec, Quebec, Canada

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Québec, Quebec, Canada

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Saint-Charles-Borromée, Quebec, Canada

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Saint-Hyacinthe, Quebec, Canada

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Sainte-Foy, Quebec, Canada

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Trois-Rivières, Quebec, Canada

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Saskatoon, Saskatchewan, Canada

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San Juan, , Puerto Rico

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Countries

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United States Canada Puerto Rico

References

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Johnson S, Louie TJ, Gerding DN, Cornely OA, Chasan-Taber S, Fitts D, Gelone SP, Broom C, Davidson DM; Polymer Alternative for CDI Treatment (PACT) investigators. Vancomycin, metronidazole, or tolevamer for Clostridium difficile infection: results from two multinational, randomized, controlled trials. Clin Infect Dis. 2014 Aug 1;59(3):345-54. doi: 10.1093/cid/ciu313. Epub 2014 May 5.

Reference Type DERIVED
PMID: 24799326 (View on PubMed)

Other Identifiers

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GD3-170-301

Identifier Type: -

Identifier Source: org_study_id

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