Study Of An FDA-approved Drug As Additional Therapy In Patients With Schizophrenia

NCT ID: NCT00086593

Last Updated: 2016-10-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

209 participants

Study Classification

INTERVENTIONAL

Study Start Date

2004-05-31

Study Completion Date

2005-07-31

Brief Summary

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This is a 12-week study for the treatment of chronic persistent symptoms in participants with schizophrenia. Participants on a stable, optimal dose of up to two atypical antipsychotics who fulfill the screening criteria will be randomized to receive either an FDA-approved drug or placebo in addition to the current treatment. Safety will be closely monitored through vital signs, various tests, and blood and urine samples.

Detailed Description

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Conditions

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Schizophrenia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Interventions

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lamotrigine

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Diagnosed with schizophrenia.
* Exhibits persistent positive symptoms that have persisted for a minimum of 3 months prior to screening.
* Continuously taking 1-2 specific atypical antipsychotics for a minimum of 3 months and must be on a stable dose for at least 1 month prior to entering the study.
* Participant or a legal guardian is able to understand and sign the consent form.

Exclusion Criteria

* PANSS (Positive and Negative Syndrome Score) total score increases or decreases by more than 20% between the Screening and Baseline visits.
* Predominant Axis I disorder other than schizophrenia within 6 months prior to screening.
* History of clinically significant or unstable medical disorder or treatment that would interfere with the study.
* History of autistic disorder or another pervasive developmental disorder, organic brain disease, dementia, stroke, epilepsy or a history of seizures requiring treatment (this does not include febrile seizures as a child), or those who have suffered a traumatic head injury.
* Taking psychotropic or primarily centrally active medication at screening.
* Use of antidepressant medications or mood stabilizers within 1 month of screening.
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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GlaxoSmithKline

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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GSK Clinical Trials

Role: STUDY_DIRECTOR

GlaxoSmithKline

Locations

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GSK Investigational Site

Little Rock, Arkansas, United States

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Garden Grove, California, United States

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Glendale, California, United States

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Los Angeles, California, United States

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Pico Rivera, California, United States

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San Diego, California, United States

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Sherman Oaks, California, United States

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Coral Springs, Florida, United States

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Maitland, Florida, United States

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Miami, Florida, United States

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North Miami, Florida, United States

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Winter Park, Florida, United States

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Niles, Illinois, United States

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Oak Brook, Illinois, United States

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Indianapolis, Indiana, United States

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Indianapolis, Indiana, United States

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Staten Island, New York, United States

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Nashville, Tennessee, United States

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Bellaire, Texas, United States

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San Antonio, Texas, United States

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Madison, Wisconsin, United States

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Edmonton, Alberta, Canada

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Edmonton, Alberta, Canada

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Kelowna, British Columbia, Canada

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Winnipeg, Manitoba, Canada

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Miramichi, New Brunswick, Canada

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Dartmouth, Nova Scotia, Canada

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Sydney, Nova Scotia, Canada

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Burlington, Ontario, Canada

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Greater Sudbury, Ontario, Canada

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London, Ontario, Canada

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Mississauga, Ontario, Canada

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Toronto, Ontario, Canada

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Windsor, Ontario, Canada

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Bedford, Bedfordshire, United Kingdom

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Cambridge, Cambridgeshire, United Kingdom

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Glasgow, Lanarkshire, United Kingdom

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Coventry, Warwickshire, United Kingdom

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GSK Investigational Site

Hull, , United Kingdom

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Countries

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United States Canada United Kingdom

Study Documents

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Document Type: Study Protocol

For additional information about this study please refer to the GSK Clinical Study Register

View Document

Document Type: Dataset Specification

For additional information about this study please refer to the GSK Clinical Study Register

View Document

Document Type: Informed Consent Form

For additional information about this study please refer to the GSK Clinical Study Register

View Document

Document Type: Statistical Analysis Plan

For additional information about this study please refer to the GSK Clinical Study Register

View Document

Document Type: Clinical Study Report

For additional information about this study please refer to the GSK Clinical Study Register

View Document

Document Type: Individual Participant Data Set

For additional information about this study please refer to the GSK Clinical Study Register

View Document

Related Links

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https://www.clinicalstudydatarequest.com

Researchers can use this site to request access to anonymised patient level data and/or supporting documents from clinical studies to conduct further research.

Other Identifiers

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101464

Identifier Type: -

Identifier Source: org_study_id

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