Docetaxel, Estramustine, and Thalidomide in Treating Patients With Androgen-Independent Metastatic Adenocarcinoma of the Prostate

NCT ID: NCT00083005

Last Updated: 2012-03-15

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: PHASE2
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2004-03-31
• Study Completion Date: 2007-12-31

Brief Summary

RATIONALE: Drugs used in chemotherapy, such as docetaxel and estramustine, work in different ways to stop tumor cells from dividing so they stop growing or die. Thalidomide may stop the growth of prostate cancer by stopping blood flow to the tumor. Giving chemotherapy together with thalidomide may kill more tumor cells.

PURPOSE: This phase II trial is studying how well giving docetaxel and estramustine together with thalidomide works in treating patients with androgen-independent metastatic adenocarcinoma (cancer) of the prostate.

Detailed Description

OBJECTIVES:

Primary

• Determine the prostate-specific antigen response in patients with androgen-independent metastatic adenocarcinoma of the prostate treated with docetaxel, estramustine, and thalidomide.

Secondary

• Determine the survival duration in patients treated with this regimen.
• Determine the pharmacokinetics of both docetaxel and thalidomide in patients treated with this regimen.
• Determine whether any pharmacodynamic relationships exist between plasma concentrations of docetaxel and/or thalidomide and clinical activity or toxicity of this regimen in these patients.
• Determine the existence of and quantification of circulating prostate cancer cells in patients before and after treatment with this regimen.
• Determine genotype, with regard to cytochrome P450 2C19 polymorphism, in patients treated with this regimen.
• Correlate genotype with pharmacokinetics and efficacy of this regimen in these patients.
• Determine the changes in molecular markers of angiogenesis (including, but not limited to, serum and urine vascular endothelial growth factor) in patients before and after treatment with this regimen.
• Determine the toxicity profile of this regimen in these patients.

OUTLINE: This is an open-label study.

Patients receive docetaxel IV over 30 minutes on days 2, 9, and 16, oral thalidomide once daily on days 1-28, and oral estramustine three times daily on days 1-3, 8-10, and 15-17. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity.

Patients are followed for survival.

PROJECTED ACCRUAL: A total of 33-60 patients will be accrued for this study within 11-20 months.

Conditions

Prostate Cancer

Study Design

• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Interventions

docetaxel

Intervention Type: DRUG

estramustine phosphate sodium

Intervention Type: DRUG

thalidomide

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed adenocarcinoma of the prostate

• Metastatic disease
• Androgen-independent disease
• Clinically progressive disease documented by at least 1 of the following parameters:

• Two consecutively rising prostate-specific antigen (PSA) levels taken at least 1 week apart

• PSA ≥ 5.0 ng/mL
• Continued rise in PSA 4 weeks after discontinuation of prior flutamide OR 6 weeks after discontinuation of prior bicalutamide or nilutamide (for patients treated with anti-androgen agents)
• At least 1 new lesion on bone scan
• Progressive measurable disease
• Must have undergone bilateral surgical castration OR continue on a gonadotropin-releasing hormone agonist
• No brain metastases

PATIENT CHARACTERISTICS:

Age

• 18 and over

Performance status

• ECOG 0-2

Life expectancy

• Not specified

Hematopoietic

• Absolute neutrophil count > 1,500/mm^3
• Platelet count ≥ 100,000/mm^3*
• Hemoglobin ≥ 7.5 g/dL* NOTE: *No transfusions within the past 2 weeks

Hepatic

• AST and ALT < 2.5 times upper limit of normal (ULN)
• Bilirubin < ULN (≤ 3.0 times ULN for patients with Gilbert's syndrome)
• Alkaline phosphatase ≤ 2.5 times ULN OR
• Fractionated hepatic alkaline phosphatase ≤ 2.5 times ULN

Renal

• Creatinine ≤ 1.5 mg/dL OR
• Creatinine clearance ≥ 40 mL/min

Cardiovascular

• No transient ischemic attacks or cerebrovascular accident within the past 2 years
• No myocardial infarction within the past 6 months
• No uncontrolled congestive heart failure
• No uncontrolled angina pectoris
• No thromboembolic disease

Other

• No peripheral neuropathy ≥ grade 2
• No cognitive impairment that would preclude study participation or giving informed consent
• No other active malignancy within the past 2 years except non-melanoma skin cancer or superficial bladder carcinoma
• Fertile patients must use effective contraception for at least 1 month before, during, and for at least 1 month after study treatment

PRIOR CONCURRENT THERAPY:

Biologic therapy

• No prior thalidomide

Chemotherapy

• No prior docetaxel
• No prior estramustine
• No prior chemotherapy for metastatic prostate cancer

Endocrine therapy

• See Disease Characteristics

Radiotherapy

• Recovered from prior radiotherapy

Surgery

• See Disease Characteristics
• Recovered from prior surgery

Other

• No concurrent antiretroviral therapy for HIV-positive patients
• No concurrent complementary or alternative therapy that would interact with study drugs
• No concurrent herbal or nutritional products or dietary supplements that would interact with study drugs
• No concurrent aprepitant as secondary prophylaxis or antiemetic treatment

• Minimum Eligible Age: 18 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: No

Sponsors

National Cancer Institute (NCI)

NIH

Sponsor Role: collaborator

National Institutes of Health Clinical Center (CC)

NIH

Sponsor Role: lead

Principal Investigators

Avi S. Retter, MD

Role: STUDY_CHAIR

Eastchester Center for Cancer Care

Locations

Warren Grant Magnuson Clinical Center - NCI Clinical Trials Referral Office

Bethesda, Maryland, United States

NCI - Center for Cancer Research

Bethesda, Maryland, United States

Countries

United States

References

Sissung TM, Danesi R, Kirkland CT, Baum CE, Ockers SB, Stein EV, Venzon D, Price DK, Figg WD. Estrogen receptor alpha and aromatase polymorphisms affect risk, prognosis, and therapeutic outcome in men with castration-resistant prostate cancer treated with docetaxel-based therapy. J Clin Endocrinol Metab. 2011 Feb;96(2):E368-72. doi: 10.1210/jc.2010-2070. Epub 2010 Nov 24.

Reference Type: BACKGROUND

PMID: 21106711 (View on PubMed)

Other Identifiers

04-C-0132

Identifier Type: -

Identifier Source: secondary_id

CDR0000361758

Identifier Type: -

Identifier Source: secondary_id

040132

Identifier Type: -

Identifier Source: org_study_id

NCT00078650

Identifier Type: -

Identifier Source: nct_alias