Assessing Women's Attitudes About the Risk of Infertility Related to Adjuvant Therapy for Early Breast Cancer

NCT ID: NCT00062400

Last Updated: 2013-10-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

385 participants

Study Classification

INTERVENTIONAL

Study Start Date

2003-05-31

Brief Summary

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RATIONALE: Adjuvant therapy given after surgery for early breast cancer may cause infertility. Assessing young women's attitudes and feelings about the risk of infertility may help improve the ability to plan effective treatment.

PURPOSE: This clinical trial is studying young women's attitudes and feelings about the risk of infertility related to adjuvant therapy for stage I or stage II breast cancer.

Detailed Description

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OBJECTIVES:

* Determine the attitude toward the risk of infertility related to adjuvant therapy in women with early breast cancer.
* Correlate, if possible, the patient's attitude with the fact that the patient already has children or the time interval between the date of breast cancer diagnosis and the date of study participation.

OUTLINE: This is a multicenter study.

Patients complete a questionnaire administered by a nontreating physician.

PROJECTED ACCRUAL: A total of 385 patients will be accrued for this study.

Conditions

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Breast Cancer Psychosocial Effects of Cancer and Its Treatment Sexual Dysfunction and Infertility Sexuality and Reproductive Issues

Keywords

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sexual dysfunction and infertility sexuality and reproductive issues psychosocial effects of cancer and its treatment stage II breast cancer stage IA breast cancer stage IB breast cancer

Interventions

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psychosocial assessment and care

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

DISEASE CHARACTERISTICS:

* Histologically or cytologically confirmed prior or current diagnosis of breast cancer

* Stage I or II
* No relapsed disease
* No evidence of infertility

* Regular menses or regular hormonal contraception use for the past 3 months
* Hormonal status:

* Not specified

PATIENT CHARACTERISTICS:

Age

* 35 and under at diagnosis

Sex

* Female

Menopausal status

* Premenopausal

Performance status

* Not specified

Life expectancy

* Not specified

Hematopoietic

* Not specified

Hepatic

* Not specified

Renal

* Not specified

Other

* No psychological, familial, sociological, or geographical condition that would preclude study compliance

PRIOR CONCURRENT THERAPY:

Biologic therapy

* Not specified

Chemotherapy

* Not specified

Endocrine therapy

* See Disease Characteristics

Radiotherapy

* Not specified

Surgery

* Not specified
Maximum Eligible Age

35 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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German Adjuvant Breast Cancer Group

OTHER

Sponsor Role collaborator

ETOP IBCSG Partners Foundation

NETWORK

Sponsor Role collaborator

European Organisation for Research and Treatment of Cancer - EORTC

NETWORK

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Zora Neskovic-Konstantinovic

Role: STUDY_CHAIR

Institute Of Oncology & Radiology, Belgrade, Serbia

Locations

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Institut Jules Bordet

Brussels, , Belgium

Site Status

Centre Hospitalier Etterbeek Ixelles

Brussels, , Belgium

Site Status

CHU Liege - Domaine Universitaire du Sart Tilman

Liège, , Belgium

Site Status

Algemeen Ziekenhuis Sint-Augustinus

Wilrijk, , Belgium

Site Status

Instituto de Radiomedicina

Santiago, , Chile

Site Status

Clinica Alemana

Santiago, , Chile

Site Status

Hospital Militar

Santiago, , Chile

Site Status

University Hospital Rebro

Zagreb, , Croatia

Site Status

Klinikum der J.W. Goethe Universitaet

Frankfurt, , Germany

Site Status

Universitatsklinikum Heidelberg

Heidelberg, , Germany

Site Status

Centro di Riferimento Oncologico - Aviano

Aviano, , Italy

Site Status

Azienda Istituti Ospitalieri

Cremona, , Italy

Site Status

Ospedale Alessandro Manzoni

Lecco, , Italy

Site Status

European Institute of Oncology

Milan, , Italy

Site Status

American University of Beirut Medical Center

Beirut, , Lebanon

Site Status

Academisch Medisch Centrum at University of Amsterdam

Amsterdam, , Netherlands

Site Status

Arnhems Radiotherapeutisch Instituut

Arnhem, , Netherlands

Site Status

Instituto Nacional de Enfermedades Neoplasicas

Lima, , Peru

Site Status

Medical University of Gdansk

Gdansk, , Poland

Site Status

Instituto Portugues de Oncologia de Francisco Gentil - Centro Regional de Oncologia de Lisboa, SA

Lisbon, , Portugal

Site Status

Institute of Oncology and Radiology of Serbia

Belgrade, , Serbia

Site Status

Groote Schuur Hospital

Cape Town, , South Africa

Site Status

Inselspital Bern

Bern, , Switzerland

Site Status

Ospedale Beata Vergine

Mendrisio, , Switzerland

Site Status

Kantonsspital - St. Gallen

Sankt Gallen, , Switzerland

Site Status

Marmara University Hospital

Istanbul, , Turkey (Türkiye)

Site Status

Western Infirmary

Glasgow, Scotland, United Kingdom

Site Status

Countries

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Serbia and Montenegro Belgium Chile Croatia Germany Italy Lebanon Netherlands Peru Poland Portugal Serbia South Africa Switzerland Turkey (Türkiye) United Kingdom

References

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Neskovic-Konstantinovic Z, Gomez H, Senkus-Konefka E, et al.: A Breast International Group survey of young breast cancer patients attitudes towards the risk of loss of fertility related to adjuvant therapies: EORTC protocol 10002 - BIG 3-98. [Abstract] 31st Annual San Antonio Breast Cancer Symposium, December 10-14, 2008, San Antonio, Texas. A-3106, 2008.

Reference Type RESULT

Other Identifiers

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EORTC-10002

Identifier Type: -

Identifier Source: secondary_id

BIG-3-98

Identifier Type: -

Identifier Source: secondary_id

IBCSG-29-03

Identifier Type: -

Identifier Source: secondary_id

EORTC-10002

Identifier Type: -

Identifier Source: org_study_id