Study of the Safety and Efficacy of CC-5013 Treatment For Patients With Myelodysplastic Syndrome

NCT ID: NCT00044382

Last Updated: 2019-11-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2002-02-01

Study Completion Date

2007-01-30

Brief Summary

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To estimate the percent of patients with myelodysplastic syndromes (MDS) who experience erythroid response and the interval to response with daily treatment of 25 mg of CC-5013 .

Detailed Description

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Conditions

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Myelodysplastic Syndrome

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Interventions

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CC-5013

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Diagnosis of de novo myelodysplastic syndrome of at least 12 weeks duration.
* Baseline mean hemoglobin \< 10.0 g/dL (untransfused) and/or be transfusion dependent defined by requiring at least 4 units of RBC in the 8 weeks prior to baseline.
* More than 30 days must have elapsed since any previous treatment for MDS, other than transfusion.
* Women must not be pregnant or lactating
* No use of another experimental study drug within 30 dy\\ays of baseline
* Understand and sign written informed consent
* Able to adhere to study visit schedule, understand and comply with other protocol requirements.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Celgene

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Arizona Cancer Center

Tucson, Arizona, United States

Site Status

Countries

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United States

References

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List A, Kurtin S, Roe DJ, Buresh A, Mahadevan D, Fuchs D, Rimsza L, Heaton R, Knight R, Zeldis JB. Efficacy of lenalidomide in myelodysplastic syndromes. N Engl J Med. 2005 Feb 10;352(6):549-57. doi: 10.1056/NEJMoa041668.

Reference Type BACKGROUND
PMID: 15703420 (View on PubMed)

Other Identifiers

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CC-5013-MDS-501-001

Identifier Type: -

Identifier Source: org_study_id

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