Genotype Influence on Recovery After Traumatic Brain Injury

NCT ID: NCT00018499

Last Updated: 2009-01-21

Basic Information

• Recruitment Status: COMPLETED
• Study Classification: OBSERVATIONAL
• Study Start Date: 1998-10-31
• Study Completion Date: 2001-10-31

Brief Summary

Genetic differences in response to brain injury may reasonably be expected to play a role in the initial consequences of traumatic brain injury and in the rate of recovery from such injury.

Detailed Description

Polymorphisms in the Apolipoprotein E gene encode functional variants which differentially determine the rate at which neuronal repair can occur, and are associated with differences in expression of neurodegenerative processes, including traumatic brain injury. It is proposed that the accuracy of prediction of outcome after head injury will be significantly increased by inclusion of APOE genotype alone, or in combination with other variables such as severity of head injury, cognitive, electroencephalographic or neuroradiologic measures, or treatment strategies.

Conditions

Brain Injury

Eligibility Criteria

Exclusion Criteria

1. Unwillingness to participate in rehabilitation program or cooperate with investigators.

2. History of prior severe traumatic brain injury of other severe neurologic or psychiatric condition, such as psychosis, stroke, multiple sclerosis, or spinal cord injury.

• Minimum Eligible Age: 17 Years
• Maximum Eligible Age: 55 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

US Department of Veterans Affairs

FED

Sponsor Role: lead

Principal Investigators

Fiona Crawford, Ph.D.

Role:

Rodney Vanderploeg, Ph.D.

Role:

Robert Thatcher, Ph.D.

Role:

Andres Salazar, M.D.

Role:

Locations

James A. Haley Veterans' Hospital

Tampa, Florida, United States

Countries

United States

Other Identifiers

EPID-030-98S

Identifier Type: -

Identifier Source: org_study_id