Ischemic Heart Disease Incidence and Indices of Body-fat Distribution
NCT ID: NCT00005255
Last Updated: 2016-02-18
Study Results
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Basic Information
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COMPLETED
OBSERVATIONAL
1990-05-31
1995-04-30
Brief Summary
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Detailed Description
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Previous studies have demonstrated that abdominal obesity can be predictive of ischemic heart disease. These prospective cohort studies employed simple indices of body-fat distribution such as waist-to-hip circumference ratio or subscapular skinfold. Their similar results suggested that increased abdominal obesity conferred a two-fold increased risk of ischemic heart disease among middle-aged men. The two proposed studies permitted testing of alternative fat-distribution indices which might be stronger risk factors for ischemic heart disease incidence than the waist-to-hip-ratio or the subscapular skinfold.
DESIGN NARRATIVE:
Two parallel case-control studies were conducted. In both studies, subjects were measured for girth, skinfold, abdominal sagittal diameter, height, and weight. Analyses for both protocols considered men and women separately. Possible confounders of the association between fat-distribution indices and ischemic heart disease were considered and if required, adjusted for in multivariate analyses. Possible confounders included race, age, tobacco use, alcohol use, diabetes, social class, hypertension, cholesterol levels, and physical activity levels.
The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.
Conditions
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Eligibility Criteria
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Inclusion Criteria
100 Years
MALE
No
Sponsors
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National Heart, Lung, and Blood Institute (NHLBI)
NIH
References
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Kahn HS, Williamson DF. Abdominal obesity and mortality risk among men in nineteenth-century North America. Int J Obes Relat Metab Disord. 1994 Oct;18(10):686-91.
Kahn HS. Choosing an index for abdominal obesity: an opportunity for epidemiologic clarification. J Clin Epidemiol. 1993 May;46(5):491-4. doi: 10.1016/0895-4356(93)90027-x.
Kahn HS, Simoes EJ, Koponen M, Hanzlick R. The abdominal diameter index and sudden coronary death in men. Am J Cardiol. 1996 Oct 15;78(8):961-4. doi: 10.1016/s0002-9149(96)00479-1.
Kahn HS. The accumulation of visceral adipose tissue may be influenced by intra-abdominal temperature. Obes Res. 1996 May;4(3):297-9. doi: 10.1002/j.1550-8528.1996.tb00550.x.
Kahn HS, Austin H, Williamson DF, Arensberg D. Simple anthropometric indices associated with ischemic heart disease. J Clin Epidemiol. 1996 Sep;49(9):1017-24. doi: 10.1016/0895-4356(96)00113-8.
Other Identifiers
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1137
Identifier Type: -
Identifier Source: org_study_id
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