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Clinical Trials

Showing trials with last updates posted in 2025.

NCT05657301 | ACTIVE_NOT_RECRUITING | PHASE1
25 Participants

Safety and Tolerability of KH631 Gene Therapy in Participants With Neovascular Age-related Macular Degeneration

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-10-16
Completion: 2026-09-30
Conditions
Age-Related Macular Degeneration
Interventions
DRUG
No Results Yet
NCT05649722 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3
31 Participants

An Extension Study of Treprostinil Palmitil Inhalation Powder (TPIP) for Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-05-11
Completion: 2026-03-14
Conditions
Pulmonary Hypertension Interstitial Lung Disease
Interventions
DRUG
No Results Yet
NCT05646641 | COMPLETED | NA
57 Participants

Strength Training in Fibromyalgia on Balance, Neuromuscular Performance and Symptoms

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2024-10-05
Completion: 2025-08-07
Conditions
Fibromyalgia
Interventions
OTHER
No Results Yet
NCT05638295 | RECRUITING | PHASE2
105 Participants

Testing the Use of AMG 510 (Sotorasib) and Panitumumab as a Targeted Treatment for KRAS G12C Mutant Solid Tumor Cancers (A ComboMATCH Treatment Trial)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2024-08-01
Completion: 2028-12-31
Conditions
Advanced Malignant Solid Neoplasm Metastatic Malignant Solid Neoplasm
Interventions
PROCEDURE BIOLOGICAL DRUG
No Results Yet
NCT05629026 | RECRUITING | NA
60 Participants

Study of Lymphatic Dysfunction in Primary and Secondary Lymphedema

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2024-02-21
Completion: 2026-02-28
Conditions
Lymphedema
Interventions
PROCEDURE
No Results Yet
NCT05627362 | ACTIVE_NOT_RECRUITING | PHASE2
68 Participants

A Study to Assess Safety and Effectiveness of Elafibranor in Adult Participants With Primary Sclerosing Cholangitis.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-12-29
Completion: 2026-08-28
Conditions
Primary Sclerosing Cholangitis
Interventions
DRUG
No Results Yet
NCT05619627 | NOT_YET_RECRUITING | PHASE1
18 Participants

Oral Dexmedetomidine in Pediatric MRI

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2026-02-01
Completion: 2027-02-28
Conditions
Anesthesia
Interventions
DRUG
No Results Yet
NCT05616650 | RECRUITING | PHASE2
42 Participants

Focal Therapy With Stereotactic Body Radiation Therapy (SBRT) for Patients With a Single Prostate Tumor

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-10-19
Completion: 2027-12-01
Conditions
Prostatic Neoplasms Prostate Cancer Prostate Adenocarcinoma
Interventions
DRUG RADIATION
No Results Yet
NCT05615844 | RECRUITING | PHASE3
312 Participants

Antibiotic Cement Bead Pouch Versus Negative Pressure Wound Therapy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-11-05
Completion: 2027-03-31
Conditions
Open tíbia Fracture
Interventions
DRUG DEVICE
No Results Yet
NCT05598112 | RECRUITING | EARLY_PHASE1
210 Participants

Effect of Gut Microbiome Intervention on Aging Via Oral FMT

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-04-24
Completion: 2026-12-31
Conditions
Aging Frailty
Interventions
BIOLOGICAL OTHER
No Results Yet
NCT05589688 | RECRUITING | PHASE1
20 Participants

Individualization of Dosage Regimens in Obese Patients: Application to Acyclovir

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2024-04-09
Completion: 2026-12-31
Conditions
Obesity
Interventions
DRUG
No Results Yet
NCT05559736 | WITHDRAWN | NA
0 Participants

Artemis Proximal Femoral Nail for Internal Fixation of Intertrochanteric Femur Fractures

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-05-24
Completion: 2025-12-31
Conditions
Intertrochanteric Fractures Femoral Fracture Femoral Neck Fractures
Interventions
DEVICE
No Results Yet
NCT05553522 | TERMINATED | PHASE1
1 Participants

Tucatinib, Trastuzumab, and Capecitabine With SRS for Brain Metastases From HER-2 Positive Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2024-01-29
Completion: 2025-12-17
Conditions
Brain Metastases HER2-positive Breast Cancer
Interventions
COMBINATION_PRODUCT
No Results Yet
NCT05521256 | COMPLETED | PHASE1
70 Participants

A Research Study of a New Medicine NNC0113-6856 in Healthy Males

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-08-26
Completion: 2023-03-27
Conditions
Healthy Volunteers Type 2 Diabetes
Interventions
DRUG
No Results Yet
NCT05514340 | RECRUITING | PHASE2
40 Participants

Assess Safety and Efficacy of Sovateltide in Hypoxic-ischemic Encephalopathy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-09-06
Completion: 2026-11-30
Conditions
Hypoxic-Ischemic Encephalopathy Neonatal Asphyxia Neonatal Encephalopathy
Interventions
DRUG
No Results Yet
NCT05485831 | RECRUITING
100 Participants

Epidyolex® in Lennox Gastaut, Dravet Syndrome and Tuberous Sclerosis Complex: an Observational Study in ITALY

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2025-02-24
Completion: 2026-01-31
Conditions
Lennox Gastaut Syndrome Dravet Syndrome Tuberous Sclerosis Complex
Interventions
DRUG
No Results Yet
NCT05472883 | RECRUITING | NA
50 Participants

Identification of Human Biomarkers Predictive of Diabetes Remission in Type 2 Diabetes Patient (BARIAKINES)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-02-27
Completion: 2025-12-31
Conditions
Type 2 Diabetes
Interventions
PROCEDURE
No Results Yet
NCT05470816 | ACTIVE_NOT_RECRUITING | PHASE3
826 Participants

Tranexamic Acid to Reduce Delirium After Gastrointestinal Surgery: the TRIGS-D Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-11-01
Completion: 2026-08-13
Conditions
Surgical Site Infection Dementia Cognition
Interventions
DRUG
No Results Yet
NCT05468333 | COMPLETED | NA
184 Participants

"Natural" and "Organic" Cigarette Descriptors: Association With Expectancies, Subjective Effects, Topography, and Biomarkers of Exposure Among Daily Smokers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-01-20
Completion: 2024-08-31
Conditions
Smoking Behaviors
Interventions
OTHER
No Results Yet
NCT05463224 | ACTIVE_NOT_RECRUITING | PHASE2
150 Participants

Lazertinib for NSCLC Harboring Activating EGFR Mutations in TKI naïve Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-01-02
Completion: 2026-03-31
Conditions
NSCLC
Interventions
DRUG
No Results Yet
NCT05456295 | COMPLETED | NA
35 Participants

Comparative Effect of Carbon Fiber Orthosis Cuff Design on Preference, Comfort, and Mechanics

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-05-17
Completion: 2025-09-29
Conditions
Healthy Lower Limb Injury Post-Traumatic Osteoarthritis
Interventions
DEVICE
No Results Yet
NCT05449301 | COMPLETED | NA
63 Participants

Effects of Unilateral Step Training on Gait and Balance in Stroke Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-01-01
Completion: 2024-06-30
Conditions
Stroke
Interventions
OTHER
No Results Yet
NCT05442216 | RECRUITING | PHASE2
53 Participants

Tagraxofusp and Azacitidine With Venetoclax in Newly Diagnosed Secondary AML After Hypomethylating Agents

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2024-05-01
Completion: 2027-08-31
Conditions
Acute Myeloid Leukemia
Interventions
DRUG
No Results Yet
NCT05437562 | NOT_YET_RECRUITING | NA
120 Participants

Randomized Clinical Trial for Ewing Amputation in the VA

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2026-01-15
Completion: 2030-01-15
Conditions
Peripheral Arterial Disease
Interventions
PROCEDURE
No Results Yet
NCT05432791 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3
190 Participants

Testing Olaparib and Temozolomide Versus the Usual Treatment for Uterine Leiomyosarcoma After Chemotherapy Has Stopped Working

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-03-30
Completion: 2030-03-09
Conditions
Locally Advanced Uterine Corpus Leiomyosarcoma Metastatic Uterine Corpus Leiomyosarcoma Stage III Uterine Corpus Leiomyosarcoma AJCC v8 Stage IV Uterine Corpus Leiomyosarcoma AJCC v8 Unresectable Uterine Corpus Leiomyosarcoma
Interventions
PROCEDURE DRUG
No Results Yet
NCT05427448 | COMPLETED | NA
342 Participants

Validation of Blood Biomarkers for Alzheimer's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-11-24
Completion: 2025-05-20
Conditions
Alzheimer Disease Mild Cognitive Impairment Dementia Tauopathies
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT05410548 | COMPLETED | NA
70 Participants

Comorbidity Screening and Referral by Prosthetists

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-06-09
Completion: 2023-01-30
Conditions
Limb Ischemia Low Back Pain Depression Neuropathy;Peripheral Amputation
Interventions
OTHER
No Results Yet
NCT05389449 | ACTIVE_NOT_RECRUITING | PHASE3
80 Participants

A Long-term Safety and Efficacy Study of Danicopan as an Add-on Therapy to Complement Component 5 Inhibitor (C5i) in Participants With PNH

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-10-28
Completion: 2026-07-31
Conditions
Paroxysmal Nocturnal Hemoglobinuria
Interventions
DRUG
No Results Yet
NCT05389293 | RECRUITING | PHASE2
152 Participants

A Study of Mosunetuzumab Alone or With Zanubrutinib in People With Follicular Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-05-27
Completion: 2026-12-31
Conditions
Follicular Lymphoma Lymphoma
Interventions
DRUG
No Results Yet
NCT05379829 | COMPLETED | PHASE1
24 Participants

A Research Study of How the Medicine Ziltivekimab Works in the Body of Chinese Men and Women With Kidney Disease and Inflammation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-05-30
Completion: 2024-06-12
Conditions
Chronic Kidney Disease and Systemic Inflammation
Interventions
DRUG
No Results Yet
NCT05379023 | COMPLETED | NA
116 Participants

VIdeo Telehealth in ALzheimer's: NeuroPsychology (VITAL-NP)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-06-27
Completion: 2024-05-16
Conditions
Suspected Typical Alzheimer's Disease (AD) Suspected Atypical Alzheimer's Disease (AD)
Interventions
BEHAVIORAL
Results Available
NCT05372679 | ACTIVE_NOT_RECRUITING | NA
25 Participants

REDUCED 1 - Renal Denervation Using Ultrasonic Catheter EmitteD Energy Study /

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-11-11
Completion: 2025-12-31
Conditions
Uncontrolled Stage 2 Hypertension
Interventions
DEVICE
No Results Yet
NCT05365035 | RECRUITING | PHASE2
60 Participants

A Phase II Study of Cladribine and Low Dose Cytarabine in Combination With Venetoclax, Alternating With Azacitidine and Venetoclax, in Patients With Higher-risk Myeloproliferative Chronic Myelomonocytic Leukemia or Higher-risk Myelodysplastic Syndromes With Excess Blasts

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-09-23
Completion: 2027-12-31
Conditions
Myelodysplastic Syndromes Myeloproliferative Chronic Myelomonocytic Leukemia
Interventions
DRUG
No Results Yet
NCT05364957 | RECRUITING | NA
84 Participants

Intragastric Balloon in Obese Patients With Uncontrolled Asthma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-05-12
Completion: 2029-07-31
Conditions
Obesity Asthma
Interventions
DEVICE PROCEDURE
No Results Yet
NCT05363774 | COMPLETED | PHASE1
161 Participants

A Research Study of a New Medicine NNC0519-0130 in Healthy People, People With High Body Weight and People With Type 2 Diabetes.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-04-20
Completion: 2024-04-02
Conditions
Healthy Volunteers (Diabetes Mellitus, Type 2)
Interventions
DRUG
No Results Yet
NCT05349422 | COMPLETED | NA
1726 Participants

Addressing Antihypertensive Medication Adherence Through EHR-enabled Teamlets in Primary Care

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-10-06
Completion: 2024-11-11
Conditions
Blood Pressure Medication Adherence
Interventions
BEHAVIORAL
No Results Yet
NCT05329766 | ACTIVE_NOT_RECRUITING | PHASE2
332 Participants

A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-06-10
Completion: 2027-01-31
Conditions
Gastrointestinal Tract Malignancies
Interventions
DRUG
No Results Yet
NCT05312047 | COMPLETED
609 Participants

Continence After Vaginal Prolapse Surgery

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2022-04-04
Completion: 2025-09-19
Conditions
Pelvic Organ Prolapse Urinary Incontinence
Interventions
PROCEDURE
No Results Yet
NCT05307289 | RECRUITING | NA
20 Participants

Study of Alterations in Tumor Metabolism Associated With the Development of Immunotherapy Resistance in Melanoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-05-25
Completion: 2028-05-25
Conditions
Melanoma (Skin)
Interventions
OTHER
No Results Yet
NCT05304065 | RECRUITING | PHASE2
1600 Participants

Safe Treatment for Emergency Presentation for Suicidal Ideation and Behavior in Youth

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-10-17
Completion: 2026-12-31
Conditions
Suicide Suicidal Self-Harm
Interventions
BEHAVIORAL
No Results Yet
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