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Clinical Trials

Showing trials with last updates posted in 2025.

NCT05598112 | RECRUITING | EARLY_PHASE1
210 Participants

Effect of Gut Microbiome Intervention on Aging Via Oral FMT

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-04-24
Completion: 2026-12-31
Conditions
Aging Frailty
Interventions
BIOLOGICAL OTHER
No Results Yet
NCT05589688 | RECRUITING | PHASE1
20 Participants

Individualization of Dosage Regimens in Obese Patients: Application to Acyclovir

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2024-04-09
Completion: 2026-12-31
Conditions
Obesity
Interventions
DRUG
No Results Yet
NCT05559736 | WITHDRAWN | NA
0 Participants

Artemis Proximal Femoral Nail for Internal Fixation of Intertrochanteric Femur Fractures

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-05-24
Completion: 2025-12-31
Conditions
Intertrochanteric Fractures Femoral Fracture Femoral Neck Fractures
Interventions
DEVICE
No Results Yet
NCT05554406 | RECRUITING | PHASE2
335 Participants

Testing the Effects of Novel Therapeutics for Newly Diagnosed, Untreated Patients With High-Risk Acute Myeloid Leukemia (A MyeloMATCH Treatment Trial)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2024-09-25
Completion: 2027-03-31
Conditions
Acute Myeloid Leukemia Acute Myeloid Leukemia Arising From Previous Myelodysplastic/Myeloproliferative Neoplasm Acute Myeloid Leukemia Post Cytotoxic Therapy Acute Myeloid Leukemia, Myelodysplasia-Related
Interventions
DRUG PROCEDURE
No Results Yet
NCT05553522 | TERMINATED | PHASE1
1 Participants

Tucatinib, Trastuzumab, and Capecitabine With SRS for Brain Metastases From HER-2 Positive Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2024-01-29
Completion: 2025-12-17
Conditions
Brain Metastases HER2-positive Breast Cancer
Interventions
COMBINATION_PRODUCT
No Results Yet
NCT05521256 | COMPLETED | PHASE1
70 Participants

A Research Study of a New Medicine NNC0113-6856 in Healthy Males

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-08-26
Completion: 2023-03-27
Conditions
Healthy Volunteers Type 2 Diabetes
Interventions
DRUG
No Results Yet
NCT05514340 | RECRUITING | PHASE2
40 Participants

Assess Safety and Efficacy of Sovateltide in Hypoxic-ischemic Encephalopathy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-09-06
Completion: 2026-11-30
Conditions
Hypoxic-Ischemic Encephalopathy Neonatal Asphyxia Neonatal Encephalopathy
Interventions
DRUG
No Results Yet
NCT05485831 | RECRUITING
100 Participants

Epidyolex® in Lennox Gastaut, Dravet Syndrome and Tuberous Sclerosis Complex: an Observational Study in ITALY

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2025-02-24
Completion: 2026-01-31
Conditions
Lennox Gastaut Syndrome Dravet Syndrome Tuberous Sclerosis Complex
Interventions
DRUG
No Results Yet
NCT05472883 | RECRUITING | NA
50 Participants

Identification of Human Biomarkers Predictive of Diabetes Remission in Type 2 Diabetes Patient (BARIAKINES)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-02-27
Completion: 2025-12-31
Conditions
Type 2 Diabetes
Interventions
PROCEDURE
No Results Yet
NCT05470816 | ACTIVE_NOT_RECRUITING | PHASE3
826 Participants

Tranexamic Acid to Reduce Delirium After Gastrointestinal Surgery: the TRIGS-D Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-11-01
Completion: 2026-08-13
Conditions
Surgical Site Infection Dementia Cognition
Interventions
DRUG
No Results Yet
NCT05468333 | COMPLETED | NA
184 Participants

"Natural" and "Organic" Cigarette Descriptors: Association With Expectancies, Subjective Effects, Topography, and Biomarkers of Exposure Among Daily Smokers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-01-20
Completion: 2024-08-31
Conditions
Smoking Behaviors
Interventions
OTHER
No Results Yet
NCT05463224 | ACTIVE_NOT_RECRUITING | PHASE2
150 Participants

Lazertinib for NSCLC Harboring Activating EGFR Mutations in TKI naïve Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-01-02
Completion: 2026-03-31
Conditions
NSCLC
Interventions
DRUG
No Results Yet
NCT05456295 | COMPLETED | NA
35 Participants

Comparative Effect of Carbon Fiber Orthosis Cuff Design on Preference, Comfort, and Mechanics

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-05-17
Completion: 2025-09-29
Conditions
Healthy Lower Limb Injury Post-Traumatic Osteoarthritis
Interventions
DEVICE
No Results Yet
NCT05449301 | COMPLETED | NA
63 Participants

Effects of Unilateral Step Training on Gait and Balance in Stroke Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-01-01
Completion: 2024-06-30
Conditions
Stroke
Interventions
OTHER
No Results Yet
NCT05442216 | RECRUITING | PHASE2
53 Participants

Tagraxofusp and Azacitidine With Venetoclax in Newly Diagnosed Secondary AML After Hypomethylating Agents

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2024-05-01
Completion: 2027-08-31
Conditions
Acute Myeloid Leukemia
Interventions
DRUG
No Results Yet
NCT05437562 | NOT_YET_RECRUITING | NA
120 Participants

Randomized Clinical Trial for Ewing Amputation in the VA

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2026-01-15
Completion: 2030-01-15
Conditions
Peripheral Arterial Disease
Interventions
PROCEDURE
No Results Yet
NCT05432791 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3
190 Participants

Testing Olaparib and Temozolomide Versus the Usual Treatment for Uterine Leiomyosarcoma After Chemotherapy Has Stopped Working

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-03-30
Completion: 2030-03-09
Conditions
Locally Advanced Uterine Corpus Leiomyosarcoma Metastatic Uterine Corpus Leiomyosarcoma Stage III Uterine Corpus Leiomyosarcoma AJCC v8 Stage IV Uterine Corpus Leiomyosarcoma AJCC v8 Unresectable Uterine Corpus Leiomyosarcoma
Interventions
PROCEDURE DRUG
No Results Yet
NCT05427448 | COMPLETED | NA
342 Participants

Validation of Blood Biomarkers for Alzheimer's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-11-24
Completion: 2025-05-20
Conditions
Alzheimer Disease Mild Cognitive Impairment Dementia Tauopathies
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT05410548 | COMPLETED | NA
70 Participants

Comorbidity Screening and Referral by Prosthetists

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-06-09
Completion: 2023-01-30
Conditions
Limb Ischemia Low Back Pain Depression Neuropathy;Peripheral Amputation
Interventions
OTHER
No Results Yet
NCT05389449 | ACTIVE_NOT_RECRUITING | PHASE3
80 Participants

A Long-term Safety and Efficacy Study of Danicopan as an Add-on Therapy to Complement Component 5 Inhibitor (C5i) in Participants With PNH

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-10-28
Completion: 2026-07-31
Conditions
Paroxysmal Nocturnal Hemoglobinuria
Interventions
DRUG
No Results Yet
NCT05389293 | RECRUITING | PHASE2
152 Participants

A Study of Mosunetuzumab Alone or With Zanubrutinib in People With Follicular Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-05-27
Completion: 2026-12-31
Conditions
Follicular Lymphoma Lymphoma
Interventions
DRUG
No Results Yet
NCT05379829 | COMPLETED | PHASE1
24 Participants

A Research Study of How the Medicine Ziltivekimab Works in the Body of Chinese Men and Women With Kidney Disease and Inflammation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-05-30
Completion: 2024-06-12
Conditions
Chronic Kidney Disease and Systemic Inflammation
Interventions
DRUG
No Results Yet
NCT05379023 | COMPLETED | NA
116 Participants

VIdeo Telehealth in ALzheimer's: NeuroPsychology (VITAL-NP)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-06-27
Completion: 2024-05-16
Conditions
Suspected Typical Alzheimer's Disease (AD) Suspected Atypical Alzheimer's Disease (AD)
Interventions
BEHAVIORAL
Results Available
NCT05372679 | ACTIVE_NOT_RECRUITING | NA
25 Participants

REDUCED 1 - Renal Denervation Using Ultrasonic Catheter EmitteD Energy Study /

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-11-11
Completion: 2025-12-31
Conditions
Uncontrolled Stage 2 Hypertension
Interventions
DEVICE
No Results Yet
NCT05365035 | RECRUITING | PHASE2
60 Participants

A Phase II Study of Cladribine and Low Dose Cytarabine in Combination With Venetoclax, Alternating With Azacitidine and Venetoclax, in Patients With Higher-risk Myeloproliferative Chronic Myelomonocytic Leukemia or Higher-risk Myelodysplastic Syndromes With Excess Blasts

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-09-23
Completion: 2027-12-31
Conditions
Myelodysplastic Syndromes Myeloproliferative Chronic Myelomonocytic Leukemia
Interventions
DRUG
No Results Yet
NCT05364957 | RECRUITING | NA
84 Participants

Intragastric Balloon in Obese Patients With Uncontrolled Asthma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2023-05-12
Completion: 2029-07-31
Conditions
Obesity Asthma
Interventions
DEVICE PROCEDURE
No Results Yet
NCT05363774 | COMPLETED | PHASE1
161 Participants

A Research Study of a New Medicine NNC0519-0130 in Healthy People, People With High Body Weight and People With Type 2 Diabetes.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-04-20
Completion: 2024-04-02
Conditions
Healthy Volunteers (Diabetes Mellitus, Type 2)
Interventions
DRUG
No Results Yet
NCT05349422 | COMPLETED | NA
1726 Participants

Addressing Antihypertensive Medication Adherence Through EHR-enabled Teamlets in Primary Care

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-10-06
Completion: 2024-11-11
Conditions
Blood Pressure Medication Adherence
Interventions
BEHAVIORAL
No Results Yet
NCT05329766 | ACTIVE_NOT_RECRUITING | PHASE2
332 Participants

A Safety and Efficacy Study of Treatment Combinations With and Without Chemotherapy in Adult Participants With Advanced Upper Gastrointestinal Tract Malignancies

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-06-10
Completion: 2027-01-31
Conditions
Gastrointestinal Tract Malignancies
Interventions
DRUG
No Results Yet
NCT05312047 | COMPLETED
609 Participants

Continence After Vaginal Prolapse Surgery

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2022-04-04
Completion: 2025-09-19
Conditions
Pelvic Organ Prolapse Urinary Incontinence
Interventions
PROCEDURE
No Results Yet
NCT05307289 | RECRUITING | NA
20 Participants

Study of Alterations in Tumor Metabolism Associated With the Development of Immunotherapy Resistance in Melanoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-05-25
Completion: 2028-05-25
Conditions
Melanoma (Skin)
Interventions
OTHER
No Results Yet
NCT05304065 | RECRUITING | PHASE2
1600 Participants

Safe Treatment for Emergency Presentation for Suicidal Ideation and Behavior in Youth

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-10-17
Completion: 2026-12-31
Conditions
Suicide Suicidal Self-Harm
Interventions
BEHAVIORAL
No Results Yet
NCT05289466 | TERMINATED | NA
5 Participants

Oncoplastic Partial Mastectomy With Intraoperative Radiation Therapy (IORT) in Early Stage Breast Cancer Patients With Prior History of Chest Wall Radiation.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-12-16
Completion: 2024-10-23
Conditions
IORT-Intra-Operative Radiation Therapy
Interventions
RADIATION PROCEDURE
No Results Yet
NCT05271552 | COMPLETED | PHASE3
151 Participants

Dexmedetomidine in the Treatment of Agitation Associated With Dementia (TRANQUILITY II)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-04-27
Completion: 2023-04-21
Conditions
Agitation Dementia
Interventions
DRUG
Results Available
NCT05269004 | ACTIVE_NOT_RECRUITING | PHASE3
1300 Participants

A Rollover Study to Evaluate the Long-Term Safety and Efficacy of Ocrelizumab In Patients With Multiple Sclerosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-05-03
Completion: 2029-12-31
Conditions
Multiple Sclerosis
Interventions
DRUG
No Results Yet
NCT05260957 | RECRUITING | PHASE2
22 Participants

CAR-T Cell Therapy, Mosunetuzumab and Polatuzumab for Treatment of Refractory/Relapsed Aggressive Non-Hodgkin's Lymphoma (NHL).

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-12-14
Completion: 2026-12-31
Conditions
Refractory Non-Hodgkin Lymphoma Relapsed Non Hodgkin Lymphoma Aggressive Non-Hodgkin Lymphoma
Interventions
DRUG BIOLOGICAL
No Results Yet
NCT05238922 | RECRUITING | PHASE1
604 Participants

Study of INCB123667 in Subjects With Advanced Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-07-05
Completion: 2027-07-27
Conditions
Solid Tumors
Interventions
DRUG
No Results Yet
NCT05172011 | ACTIVE_NOT_RECRUITING
15028 Participants

Understanding the Long-term Impact of COVID on Children and Families

Study Type: OBSERVATIONAL
Last Updated: 2025-12-31
Start Date: 2022-03-01
Completion: 2027-04-01
Conditions
SARS-CoV-2 Infection
No Results Yet
NCT05147662 | COMPLETED | PHASE3
36 Participants

A Study to Learn How Safe the Study Treatment BAY94-9027 is and How it Affects the Body in Previously Treated Children Aged 7 to Less Than 12 Years With Severe Hemophilia A, a Genetic Bleeding Disorder That is Caused by the Lack of a Protein Called Clotting Factor 8 (FVIII) in the Blood

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2022-03-23
Completion: 2024-01-04
Conditions
Treatment of Bleeding Prophylaxis of Bleeding Hemophilia A Children
Interventions
BIOLOGICAL
Results Available
NCT05132296 | ACTIVE_NOT_RECRUITING | NA
30 Participants

Mobile-Health Delivery of Lifestyle Interventions for Women With Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-31
Start Date: 2021-05-21
Completion: 2026-06-15
Conditions
Breast Carcinoma
Interventions
BEHAVIORAL OTHER DEVICE
No Results Yet
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