Clinical Trials Updated in 2025

NCT06492616 | RECRUITING | PHASE3

4220 Participants

A Study of Elacestrant Versus Standard Endocrine Therapy in Women and Men With ER+,HER2-, Early Breast Cancer With High Risk of Recurrence

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-09-27

Completion: 2029-08-31

Conditions

Breast Cancer

Interventions

DRUG

No Results Yet

NCT06490991 | COMPLETED | PHASE1

16 Participants

Comparison of HRS-5965 Capsules and Tablets in Healthy Subjects

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-07-17

Completion: 2024-08-06

Conditions

Paroxysmal Nocturnal Hemoglobinuria，IgA Nephropathy

Interventions

DRUG

No Results Yet

NCT06488716 | TERMINATED | PHASE1

12 Participants

A Study to Evaluate the Safety, Pharmacokinetics, and Activity of RO7759065 as a Single Agent and in Combination With Atezolizumab in Patients With Locally Advanced or Metastatic Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-12-16

Completion: 2025-11-05

Conditions

Solid Tumour

Interventions

DRUG

No Results Yet

NCT06486779 | RECRUITING

160 Participants

Kesimpta (Ofatumumab) in Greek Multiple Sclerosis Patients - an Observational Study

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2024-12-10

Completion: 2028-12-30

Conditions

Relapsing Multiple Sclerosis (RMS)

Interventions

OTHER

No Results Yet

NCT06479070 | RECRUITING | NA

188 Participants

Prognostic Value of Measuring CtDNA in a Cohort of Patients With Stage III and IV Upper Aero-digestive Tract (UADT) Cancer , Treated With Curative RADiOtherapy With or Without Concomitant Treatment.

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-09-30

Completion: 2026-09-30

Conditions

SCC - Squamous Cell Carcinoma Upper Aero-digestive Tract (UADT) Neoplasm

Interventions

OTHER

No Results Yet

NCT06475963 | COMPLETED

41 Participants

Evaluation of Clinical Outcomes of Scaffold Treatment of Partial Meniscal Injuries of the Knee

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2021-03-17

Completion: 2025-07-31

Conditions

Knee Osteoarthritis Knee Injuries Meniscus Lesion

Interventions

OTHER

No Results Yet

NCT06470438 | RECRUITING | PHASE1

170 Participants

A Study of JNJ-88998377 for Relapsed/Refractory B-cell Non-Hodgkin's Lymphoma

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-05-28

Completion: 2027-10-29

Conditions

Lymphoma, Non-Hodgkin Refractory B-Cell NHL Relapsed B-cell NHL

Interventions

DRUG

No Results Yet

NCT06468202 | RECRUITING | PHASE4

10742 Participants

Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: ASPIRIN TRIAL

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-10-18

Completion: 2029-01-01

Conditions

Hypertensive Disorders of Pregnancy Preeclampsia Gestational Hypertension

Interventions

DRUG

No Results Yet

NCT06465810 | RECRUITING

1850 Participants

Non-interventional Study of Patients With Transthyretin (ATTR) Amyloidosis

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2024-06-25

Completion: 2031-12-29

Conditions

Transthyretin Amyloidosis ATTR-CM ATTRv-PN ATTR ATTR-Mixed hATTR

Interventions

DRUG

No Results Yet

NCT06463028 | RECRUITING | PHASE2

40 Participants

Sapanisertib and Serabelisib (PIKTOR) With Paclitaxel and a Substudy With an Insulin-Suppressing Diet in Patients With Advanced/Recurrent Endometrial Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-12-12

Completion: 2028-09-30

Conditions

Endometrial Cancer

Interventions

DRUG

No Results Yet

NCT06461455 | COMPLETED | NA

95 Participants

Clinical Performance Evaluation of Two Frequent Replacement Silicone Hydrogel Multifocal Toric Contact Lenses

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-07-26

Completion: 2024-12-31

Conditions

Presbyopia Astigmatism

Interventions

DEVICE

Results Available

NCT06455384 | RECRUITING | NA

170 Participants

The Genetics Navigator: Evaluating a Digital Platform for Genomics Health Services

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-10-28

Completion: 2027-03-31

Conditions

Cardiac Conditions Connective Tissue Diseases Retinal Disease Epilepsy in Children Neurodevelopmental Disorders Cancer Polyposis

Interventions

BEHAVIORAL

No Results Yet

NCT06451250 | COMPLETED | NA

42 Participants

Providing Evidence-Based Approaches for Caregiver Stress Study

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-02-02

Completion: 2025-12-19

Conditions

Caregiving Stress Dementia

Interventions

OTHER

No Results Yet

NCT06445023 | RECRUITING | PHASE3

915 Participants

A Phase 3 Study of Barzolvolimab in Participants With Chronic Spontaneous Urticaria

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-07-11

Completion: 2026-10-31

Conditions

Chronic Spontaneous Urticaria

Interventions

BIOLOGICAL

No Results Yet

NCT06439082 | RECRUITING | PHASE3

315 Participants

A Study to Investigate the Efficacy and Safety of Crizanlizumab (5 mg/kg) Compared With Placebo in Adolescent and Adult Sickle Cell Disease Patients Who Experience Frequent Vaso-Occlusive Crises (SPARKLE)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-10-24

Completion: 2029-03-23

Conditions

Sickle Cell Disease

Interventions

BIOLOGICAL DRUG

No Results Yet

NCT06428409 | RECRUITING | PHASE1/PHASE2

220 Participants

A Clinical Study of MK-2870 Alone or With Other Treatments to Treat Gastrointestinal Cancers (MK-9999-02A)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-06-20

Completion: 2029-10-16

Conditions

Colorectal Cancer Pancreatic Ductal Adenocarcinoma Biliary Tract Cancer

Interventions

BIOLOGICAL DRUG

No Results Yet

NCT06427876 | RECRUITING

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2024-06-01

Completion: 2024-11-01

Conditions

One-lung Ventilation

No Results Yet

NCT06365216 | ACTIVE_NOT_RECRUITING | PHASE2

80 Participants

ALS Phase II Study of NX210c

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-10-25

Completion: 2026-02-01

Conditions

Amyotrophic Lateral Sclerosis

Interventions

DRUG

No Results Yet

NCT06360289 | RECRUITING

500 Participants

Observational Study of Neurofilament Light Chain (NfL) as a Biomarker in Asymptomatic Carriers of the Transthyretin (TTR) Variants and Patients With Hereditary Transthyretin-mediated (hATTR) Amyloidosis With Polyneuropathy

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2024-04-25

Completion: 2027-12-01

Conditions

Hereditary Amyloidosis, Transthyretin-Related Asymptomatic Carrier State

Interventions

OTHER

No Results Yet

NCT06357377 | NOT_YET_RECRUITING | PHASE1

12 Participants

A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2025-12-31

Completion: 2026-10-31

Conditions

Pediatric Tumor of CNS Pediatric Tumor of Brain Diffuse Midline Glioma, H3 K27M-Mutant Pediatric Tumor of Brain Stem Pineocytoma Choroid Plexus Carcinoma, Childhood Spinal Cord Tumor High Grade Glioma

Interventions

DRUG

No Results Yet

NCT06347588 | ACTIVE_NOT_RECRUITING

60 Participants

Risk of Reactivation of Occult Hepatitis B in Cancer Patients During Immunotherapy.

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2022-06-06

Completion: 2026-05-31

Conditions

Occult Hepatitis B Infection in Cancer Patients

Interventions

OTHER

No Results Yet

NCT06346262 | RECRUITING | PHASE4

30 Participants

Seizure Rescue Medication (RM) as Part of a Comprehensive Epilepsy Self-management Package of Care

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-03-05

Completion: 2026-01-01

Conditions

Epilepsy

Interventions

BEHAVIORAL DRUG

No Results Yet

NCT06345157 | ACTIVE_NOT_RECRUITING

378 Participants

ITAKOS - Italian Observation, Multicenter, Prospective Study of Ofatumumab in RRMS Patients

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2024-07-30

Completion: 2026-06-30

Conditions

Multiple Sclerosis, Relapsing-Remitting

Interventions

DRUG

No Results Yet

NCT06343805 | RECRUITING | PHASE1

76 Participants

A Phase 1 Study of AJ1-11095 in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed by a Type I JAK2 Inhibitor (JAK2i)

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-10-23

Completion: 2026-10-15

Conditions

Primary Myelofibrosis Post-Essential Thrombocythemia Myelofibrosis Post-Polycythemia Vera Myelofibrosis PMF PPV-MF PET-MF

Interventions

DRUG

No Results Yet

NCT06339138 | ACTIVE_NOT_RECRUITING

589 Participants

Identification of Novel High Quality Methylated DNA Markers in Renal Tumors: Whole Methylome Discovery, Tissue Validation, and Feasibility Testing In Blood and Urine, The INQUIRE Study

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2018-06-27

Completion: 2027-01-31

Conditions

Chromophobe Renal Cell Carcinoma Clear Cell Papillary Renal Tumor Clear Cell Renal Cell Carcinoma Kidney Oncocytoma Papillary Renal Cell Carcinoma Urothelial Carcinoma

Interventions

OTHER

No Results Yet

NCT06334133 | RECRUITING | PHASE3

150 Participants

Cadisegliatin as Adjunctive Therapy to Insulin in Participants With Type 1 Diabetes

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-06-14

Completion: 2026-09-30

Conditions

Diabetes Mellitus, Type 1

Interventions

DRUG

No Results Yet

NCT06328673 | ACTIVE_NOT_RECRUITING | PHASE1

160 Participants

A Study of DM919 Alone and in Combination With Pembrolizumab in Advanced Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-04-09

Completion: 2026-03-01

Conditions

Advanced Solid Tumor

Interventions

DRUG

No Results Yet

NCT06321718 | COMPLETED | NA

96 Participants

Pericapsular Nerve Group Block vs Supra Inguinal Fascia Iliaca Compartment Block

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-05-01

Completion: 2025-11-01

Conditions

Pain, Postoperative

Interventions

PROCEDURE

No Results Yet

NCT06321094 | COMPLETED

149 Participants

Effect of Vericiguat on Acute Coronary Syndrome( ACS）Patients With Ejection Fraction <45%

Study Type: OBSERVATIONAL

Last Updated: 2025-12-24

Start Date: 2024-01-31

Completion: 2025-10-01

Conditions

Acute Coronary Syndrome Heart Failure With Reduced Ejection Fraction

No Results Yet

NCT06318273 | RECRUITING | PHASE1

140 Participants

A Study to Assess Adverse Events, and How Intravenously (IV) Infused ABBV-969 Moves Through the Bodies of Adult Participants With Metastatic Castration-Resistant Prostate Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-12-24

Start Date: 2024-03-08

Completion: 2027-05-31

Conditions

Metastatic Castration-Resistant Prostate Cancer

Interventions

DRUG

No Results Yet