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Clinical Trials

Showing trials with last updates posted in 2025.

NCT06419920 | RECRUITING | NA
35 Participants

Prosthetic Performance Enhancement Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-06-26
Completion: 2026-11-30
Conditions
Amputation Lower Limb Amputation Below Knee (Injury) Lower Limb Amputation Above Knee (Injury) Lower Limb Amputation at Ankle (Injury) Lower Limb Amputation Knee Lower Limb Amputation at Hip (Injury)
Interventions
OTHER
No Results Yet
NCT06416969 | RECRUITING | EARLY_PHASE1
24 Participants

Regional Lipolysis and Adipocyte Lipolysis Protein Stimulation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-01-01
Completion: 2027-04-01
Conditions
Obesity
Interventions
DRUG
No Results Yet
NCT06413797 | COMPLETED | NA
928 Participants

Little Cigar and Cigarillo Warnings for Youth

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-07-18
Completion: 2024-11-25
Conditions
Little Cigars and Cigarillos (LCC) Use
Interventions
BEHAVIORAL
Results Available
NCT06413706 | RECRUITING | PHASE2
45 Participants

A Study Comparing Abemaciclib Plus Temozolomide to Temozolomide Monotherapy in Children and Young Adults With High-grade Glioma Following Radiotherapy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-10-25
Completion: 2027-11-30
Conditions
Glioma
Interventions
DRUG
No Results Yet
NCT06410443 | RECRUITING | NA
60 Participants

Efficacy and Safety of Local Glucocorticoids for the Treatment of Acute Radiation-Induced Intestinal Injury

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-08-01
Completion: 2026-12-31
Conditions
Radiation-Induced Intestinal Injury
Interventions
DRUG
No Results Yet
NCT06404437 | ACTIVE_NOT_RECRUITING
100 Participants

Detection of Aortic Stenosis With Smartphone Auscultation Using Machine Learning (HEARTBEAT-Pilot)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2023-03-09
Completion: 2024-05-22
Conditions
Aortic Valve Stenosis
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT06396650 | NOT_YET_RECRUITING | NA
40 Participants

Assessment of Fall Risks and Subject-specific Training for Fall Reduction

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-12-31
Completion: 2029-04-30
Conditions
Fall Risk
Interventions
DEVICE
No Results Yet
NCT06395506 | RECRUITING | NA
60 Participants

THRIVE Well Cancer FDTN/Exercise_Creatine Supplementation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-10-29
Completion: 2028-05-31
Conditions
Breast Cancer Breast Cancer Female Muscle Weakness
Interventions
DIETARY_SUPPLEMENT
No Results Yet
NCT06394323 | COMPLETED | NA
132 Participants

Supporting Oral Pre-exposure Prophylaxis Decision Making Among Pregnant Women in Lilongwe, Malawi

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-08-06
Completion: 2025-02-07
Conditions
HIV Prevention
Interventions
BEHAVIORAL
Results Available
NCT06376123 | COMPLETED
40 Participants

Nomogram for Prediction of Alveolo-arterial Gradient During One-lung Ventilation

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2024-06-01
Completion: 2024-11-01
Conditions
One-lung Ventilation
No Results Yet
NCT06365216 | ACTIVE_NOT_RECRUITING | PHASE2
80 Participants

ALS Phase II Study of NX210c

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-10-25
Completion: 2026-02-01
Conditions
Amyotrophic Lateral Sclerosis
Interventions
DRUG
No Results Yet
NCT06360289 | RECRUITING
500 Participants

Observational Study of Neurofilament Light Chain (NfL) as a Biomarker in Asymptomatic Carriers of the Transthyretin (TTR) Variants and Patients With Hereditary Transthyretin-mediated (hATTR) Amyloidosis With Polyneuropathy

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2024-04-25
Completion: 2027-12-01
Conditions
Hereditary Amyloidosis, Transthyretin-Related Asymptomatic Carrier State
Interventions
OTHER
No Results Yet
NCT06357377 | NOT_YET_RECRUITING | PHASE1
12 Participants

A Study of the Safety, Dosing, and Delivery of NEO100 in Patients With Pediatric Brain Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2025-12-31
Completion: 2026-10-31
Conditions
Pediatric Tumor of CNS Pediatric Tumor of Brain Diffuse Midline Glioma, H3 K27M-Mutant Pediatric Tumor of Brain Stem Pineocytoma Choroid Plexus Carcinoma, Childhood Spinal Cord Tumor High Grade Glioma
Interventions
DRUG
No Results Yet
NCT06347588 | ACTIVE_NOT_RECRUITING
60 Participants

Risk of Reactivation of Occult Hepatitis B in Cancer Patients During Immunotherapy.

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2022-06-06
Completion: 2026-05-31
Conditions
Occult Hepatitis B Infection in Cancer Patients
Interventions
OTHER
No Results Yet
NCT06346262 | RECRUITING | PHASE4
30 Participants

Seizure Rescue Medication (RM) as Part of a Comprehensive Epilepsy Self-management Package of Care

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-03-05
Completion: 2026-01-01
Conditions
Epilepsy
Interventions
BEHAVIORAL DRUG
No Results Yet
NCT06345157 | ACTIVE_NOT_RECRUITING
378 Participants

ITAKOS - Italian Observation, Multicenter, Prospective Study of Ofatumumab in RRMS Patients

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2024-07-30
Completion: 2026-06-30
Conditions
Multiple Sclerosis, Relapsing-Remitting
Interventions
DRUG
No Results Yet
NCT06343805 | RECRUITING | PHASE1
76 Participants

A Phase 1 Study of AJ1-11095 in Patients With Primary Myelofibrosis (PMF), Post-Polycythemia Vera Myelofibrosis (PPV-MF), or Post-Essential Thrombocythemia Myelofibrosis (PET-MF) Who Have Been Failed by a Type I JAK2 Inhibitor (JAK2i)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-10-23
Completion: 2026-10-15
Conditions
Primary Myelofibrosis Post-Essential Thrombocythemia Myelofibrosis Post-Polycythemia Vera Myelofibrosis PMF PPV-MF PET-MF
Interventions
DRUG
No Results Yet
NCT06339138 | ACTIVE_NOT_RECRUITING
589 Participants

Identification of Novel High Quality Methylated DNA Markers in Renal Tumors: Whole Methylome Discovery, Tissue Validation, and Feasibility Testing In Blood and Urine, The INQUIRE Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2018-06-27
Completion: 2027-01-31
Conditions
Chromophobe Renal Cell Carcinoma Clear Cell Papillary Renal Tumor Clear Cell Renal Cell Carcinoma Kidney Oncocytoma Papillary Renal Cell Carcinoma Urothelial Carcinoma
Interventions
OTHER
No Results Yet
NCT06334133 | RECRUITING | PHASE3
150 Participants

Cadisegliatin as Adjunctive Therapy to Insulin in Participants With Type 1 Diabetes

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-06-14
Completion: 2026-09-30
Conditions
Diabetes Mellitus, Type 1
Interventions
DRUG
No Results Yet
NCT06328673 | ACTIVE_NOT_RECRUITING | PHASE1
160 Participants

A Study of DM919 Alone and in Combination With Pembrolizumab in Advanced Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-04-09
Completion: 2026-03-01
Conditions
Advanced Solid Tumor
Interventions
DRUG
No Results Yet
NCT06321718 | COMPLETED | NA
96 Participants

Pericapsular Nerve Group Block vs Supra Inguinal Fascia Iliaca Compartment Block

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-05-01
Completion: 2025-11-01
Conditions
Pain, Postoperative
Interventions
PROCEDURE
No Results Yet
NCT06321094 | COMPLETED
149 Participants

Effect of Vericiguat on Acute Coronary Syndrome( ACS）Patients With Ejection Fraction <45%

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2024-01-31
Completion: 2025-10-01
Conditions
Acute Coronary Syndrome Heart Failure With Reduced Ejection Fraction
No Results Yet
NCT06318273 | RECRUITING | PHASE1
140 Participants

A Study to Assess Adverse Events, and How Intravenously (IV) Infused ABBV-969 Moves Through the Bodies of Adult Participants With Metastatic Castration-Resistant Prostate Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-03-08
Completion: 2027-05-31
Conditions
Metastatic Castration-Resistant Prostate Cancer
Interventions
DRUG
No Results Yet
NCT06299540 | RECRUITING
180 Participants

Benefits of Individual Physical Activity Intervention on Health-related Quality of Life in Participants With Chronic Lymphocytic Leukemia

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2024-05-27
Completion: 2026-09-30
Conditions
Leukemia, Lymphocytic, Chronic, B-Cell
Interventions
BEHAVIORAL DRUG
No Results Yet
NCT06298227 | RECRUITING | NA
60 Participants

Erector Spinae Plane Block vs Quadratus Lumborum Block for Laparoscopic Nephrectomy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-03-11
Completion: 2026-03-30
Conditions
Kidney Diseases Kidney Failure
Interventions
OTHER
No Results Yet
NCT06297603 | ACTIVE_NOT_RECRUITING | PHASE3
320 Participants

Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-03-15
Completion: 2026-10-31
Conditions
Type 2 Diabetes
Interventions
DRUG
No Results Yet
NCT06293521 | RECRUITING | PHASE2
40 Participants

Clinical and Radiographic Success Rate of Pulpotomy Versus Pulpectomy for Management of Primary Teeth With Deep Caries

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2026-01-01
Completion: 2026-01-31
Conditions
Deep Caries
Interventions
PROCEDURE
No Results Yet
NCT06292000 | WITHDRAWN | NA
0 Participants

Examining the Effects of Morning and Evening Exercise on Glucose Regulation in Adults With Prediabetes

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-02-01
Completion: 2026-06-30
Conditions
PreDiabetes Obesity Inactivity/Low Levels of Exercise
Interventions
BEHAVIORAL
No Results Yet
NCT06283251 | RECRUITING | NA
40 Participants

PediRISE Feasibility

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-05-15
Completion: 2025-12-31
Conditions
Pediatric Cancer Financial Stress Financial Hardship Disparities
Interventions
BEHAVIORAL
No Results Yet
NCT06275087 | RECRUITING | NA
42 Participants

Differences in Speed of Recovery From Anesthesia for Intraoral Surgery

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-04-10
Completion: 2025-11-05
Conditions
Intraoral Tumor
Interventions
DRUG
No Results Yet
NCT06256380 | RECRUITING | NA
200 Participants

Comparing Enhanced Cognitive-behavior Therapy and Family-based Treatment for Adolescents With an Eating Disorder

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-03-07
Completion: 2028-12-31
Conditions
Feeding and Eating Disorders
Interventions
BEHAVIORAL
No Results Yet
NCT06255990 | RECRUITING
42 Participants

Clinical and Histological Study of a Novel Dermal Substitute

Study Type: OBSERVATIONAL
Last Updated: 2025-12-24
Start Date: 2024-01-15
Completion: 2026-06-01
Conditions
Skin Transplantation
Interventions
OTHER
No Results Yet
NCT06253507 | ENROLLING_BY_INVITATION | PHASE1/PHASE2
10 Participants

pCCLCHIM-p47 (Lentiviral Vector Transduced CD34 Plus Cells) in Patients With p47 Autosomal Recessive Chronic Granulomatous Disease (AR-CGD)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-06-25
Completion: 2027-03-31
Conditions
p47 Autosomal Recessive Chronic Granulomatous Disease
Interventions
BIOLOGICAL
No Results Yet
NCT06242678 | COMPLETED | NA
2 Participants

Evaluating Spinal Cord Stimulation for Stiff Person Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-11-01
Completion: 2025-08-21
Conditions
Stiff-Person Syndrome
Interventions
DEVICE
No Results Yet
NCT06238700 | RECRUITING | NA
80 Participants

Study on Allopregnanolone and Depression in Women Across the Menopause Transition

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-05-14
Completion: 2027-07-31
Conditions
Depression
Interventions
DIETARY_SUPPLEMENT OTHER
No Results Yet
NCT06238544 | ACTIVE_NOT_RECRUITING | PHASE2
132 Participants

Long-term Safety and Tolerability of HRS-5965 in Patients With Paroxysmal Nocturnal Hemoglobinuria

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-02-06
Completion: 2027-12-31
Conditions
Paroxysmal Nocturnal Hemoglobinuria
Interventions
DRUG
No Results Yet
NCT06227377 | RECRUITING | PHASE1
250 Participants

QTX3034 in Patients With KRAS G12D Mutation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-02-05
Completion: 2027-04-01
Conditions
Solid Tumors
Interventions
DRUG COMBINATION_PRODUCT
No Results Yet
NCT06226883 | RECRUITING | PHASE2
210 Participants

A Phase 2 Study to Evaluate MORF-057 in Adults With Moderately to Severely Active Crohn's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-07-18
Completion: 2026-11-30
Conditions
Inflammatory Bowel Diseases Crohn's Disease
Interventions
DRUG
No Results Yet
NCT06225596 | RECRUITING | PHASE2/PHASE3
956 Participants

Study BT8009-230 in Participants With Locally Advanced or Metastatic Urothelial Cancer (Duravelo-2)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2024-01-24
Completion: 2030-12-31
Conditions
Metastatic Urothelial Cancer
Interventions
DRUG
No Results Yet
NCT06219408 | RECRUITING | NA
60 Participants

CIH Stepped Care for Co-occurring Chronic Pain and PTSD

Study Type: INTERVENTIONAL
Last Updated: 2025-12-24
Start Date: 2026-01-02
Completion: 2027-05-31
Conditions
Chronic Pain Posttraumatic Stress Disorder
Interventions
BEHAVIORAL
No Results Yet
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