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Clinical Trials

Showing trials with last updates posted in 2025.

NCT06761976 | AVAILABLE

Expanded Access to Provide Sevabertinib (BAY 2927088) for the Treatment of Locally Advanced or Metastatic NSCLC With HER2 Mutation

Study Type: EXPANDED_ACCESS
Last Updated: 2025-12-23
Conditions
Advanced Non-small Cell Lung Cancer Cancer
Interventions
DRUG
No Results Yet
NCT06756308 | RECRUITING | PHASE2
25 Participants

A Study of Enasidenib in People With T-Cell Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2024-12-24
Completion: 2027-12-31
Conditions
T-cell Lymphoma
Interventions
DRUG
No Results Yet
NCT06754176 | RECRUITING | NA
100 Participants

Full-Avoidance vs. Permissive/Regulated Drinking & Outcomes On Fibrillation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2025-04-17
Completion: 2026-12-31
Conditions
Atrial Fibrillation (AF) Atrial Fibrillation (Paroxysmal)
Interventions
BEHAVIORAL
No Results Yet
NCT06747455 | RECRUITING | PHASE3
438 Participants

BCG for Therapeutic Use Phase Ⅲ Clinical Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2025-04-08
Completion: 2028-10-01
Conditions
BCG
Interventions
DRUG
No Results Yet
NCT06740708 | RECRUITING | NA
2070 Participants

Scaling Up Community-based Noncommunicable Disease Research Into Practice in Pokhara Metropolitan City of Nepal

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2025-04-28
Completion: 2026-11-30
Conditions
Hypertension Type 2 Diabetes Mellitus (T2DM) Tobacco Smoking
Interventions
BEHAVIORAL
No Results Yet
NCT06739811 | RECRUITING | NA
40 Participants

Clinical Evaluation of the Medtronic Implantable Insulin Pump System (MIIPS 2020) in Adult Subjects With Type 1 Diabetes (CIP347)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2025-03-21
Completion: 2026-06-30
Conditions
Type I Diabetes
Interventions
DEVICE
No Results Yet
NCT06735989 | COMPLETED | NA
86 Participants

Moral Reasoning Intervention on Moral Justification Abilities

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2022-11-18
Completion: 2024-02-19
Conditions
Moral Development Moral Dilemma Healthy Controls Moral Justification
Interventions
OTHER
No Results Yet
NCT06734364 | RECRUITING | NA
96 Participants

Buddy Tape vs. Splint for Metacarpal Shaft Fracture Recovery

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2025-11-05
Completion: 2027-02-05
Conditions
Non-thumb Metacarpal Shaft Fracture
Interventions
DEVICE
No Results Yet
NCT06728410 | RECRUITING | PHASE2
38 Participants

A Phase II Study of Pemigatinib Plus Durvalumab in Previously Treated Advanced Intrahepatic Cholangiocarcinoma Patients With FGFR-2 Fusion or Rearrangement

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2026-01-31
Completion: 2026-07-31
Conditions
Intrahepatic Cholangiocarcinoma FGFR2 Gene Rearrangement FGFR2 Gene Mutation
Interventions
DRUG
No Results Yet
NCT06725420 | COMPLETED | NA
63 Participants

Ultrasound-Guided Injection vs Intramuscular Steroid for Carpal Tunnel Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2024-03-15
Completion: 2025-09-19
Conditions
Carpal Tunnel Syndrome (CTS) Chronic Pain
Interventions
OTHER DEVICE
No Results Yet
NCT06725368 | RECRUITING | PHASE2
46 Participants

Carboplatin + Paclitaxel + Cetuximab (PCC) After Failure of Pembrolizumab +/- First-line Chemotherapy in Recurrent/Metastatic Squamous Cell Carcinoma of the Head and Neck

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2025-01-24
Completion: 2028-01-31
Conditions
Head and Neck Cancer
Interventions
DRUG
No Results Yet
NCT06723249 | COMPLETED | NA
45 Participants

Stingless Bee Honey Augmentation in Major Depressive Disorders

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2024-12-15
Completion: 2025-08-10
Conditions
Major Depressive Disorder (MDD)
Interventions
DIETARY_SUPPLEMENT
No Results Yet
NCT06717698 | RECRUITING | PHASE2
465 Participants

A Research Study Comparing How Well Different Doses of the Medicine NNC0519-0130 Can Reduce Kidney Damage in People Living With Chronic Kidney Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2024-12-02
Completion: 2026-09-01
Conditions
Chronic Kidney Disease
Interventions
DRUG
No Results Yet
NCT06712680 | RECRUITING | PHASE1/PHASE2
115 Participants

A Phase I/II Study of HYP-6589 Monotherapy in Treating Advanced Solid Tumors and in Combination With Tyrosine Kinase Inhibitors in Treating Patients With Advanced NSCLC Positive for Driver Genes

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2024-11-27
Completion: 2028-04-10
Conditions
Solid Tumor
Interventions
DRUG
No Results Yet
NCT06712290 | WITHDRAWN | NA
0 Participants

Connective Tissue Matrix Compared to Steroid Injections for Rotator Cuff Tendinopathy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2024-11-25
Completion: 2025-12-17
Conditions
Rotator Cuff Tendinopathy
Interventions
DRUG
No Results Yet
NCT06703398 | RECRUITING | PHASE2
98 Participants

A Study of GC101 TIL in Advanced Melanoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2024-12-20
Completion: 2026-07-10
Conditions
Melanoma
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT06700447 | ACTIVE_NOT_RECRUITING | NA
2163 Participants

Protecting Against HIV Vaccine Misinformation With Adolescent Girls and Young Women in South Africa

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2025-07-24
Completion: 2026-12-31
Conditions
Misinformation HIV Vaccine
Interventions
BEHAVIORAL
No Results Yet
NCT06690775 | RECRUITING | PHASE2
230 Participants

CATALINA-2: A Clinical Study of TORL-1-23 in Platinum-resistant Ovarian Cancer.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2024-11-20
Completion: 2027-10-31
Conditions
Epithelial Ovarian Cancer Primary Peritoneal Fallopian Tube Cancer Endometrioid Ovarian Cancer
Interventions
DRUG
No Results Yet
NCT06688370 | TERMINATED
12 Participants

The Performance and Safety of Petit Drill in the French Paediatric Population: a Post-market Clinical Follow-up Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2024-03-14
Completion: 2024-11-07
Conditions
Sore-throat Cough
Interventions
DEVICE
Results Available
NCT06687980 | RECRUITING | PHASE3
136 Participants

A Study to Investigate Improvement in Pruritus of Lichen Simplex Chronicus With Dupilumab Injections Compared With Placebo in Male and Female Participants Aged at Least 18 Years (STYLE 2)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2024-11-25
Completion: 2027-04-12
Conditions
Lichen Simplex Chronicus
Interventions
DRUG
No Results Yet
NCT06687967 | RECRUITING | PHASE3
136 Participants

A Study to Investigate Improvement in Pruritus of Lichen Simplex Chronicus With Dupilumab Injections Compared With Placebo in Male and Female Participants Aged at Least 18 Years (STYLE 1)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2024-11-28
Completion: 2027-04-12
Conditions
Lichen Simplex Chronicus
Interventions
DRUG
No Results Yet
NCT06684964 | RECRUITING
40 Participants

RWE,NIS,Prospective Study for the Effectiveness, Tolerability and Adherence of Asciminib in Saudi Arabia. (ASC4REAL)

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2025-03-24
Completion: 2026-12-30
Conditions
Chronic Myelogenous Leukemia in Chronic Phase
Interventions
OTHER
No Results Yet
NCT06680557 | COMPLETED | NA
49 Participants

Exercises on Children and Adolescents With Type 1 Diabetes Mellitus (T1DM)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2025-01-01
Completion: 2025-08-31
Conditions
Diabetes Mellitus, Type 1
Interventions
BEHAVIORAL
No Results Yet
NCT06680128 | RECRUITING | PHASE1/PHASE2
402 Participants

A Study to Assess the Safety, Reactogenicity, and Immunogenicity of SK Japanese Encephalitis Messenger Ribonucleic Acid (mRNA) Vaccines (GBP560) in Healthy Adults

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2025-02-24
Completion: 2026-06-26
Conditions
Japanese Encephalitis Virus Disease
Interventions
BIOLOGICAL
No Results Yet
NCT06675812 | ACTIVE_NOT_RECRUITING | NA
200 Participants

Improving Help-seeking Propensity Through a Micro-intervention Targeting Common Concerns Among Individuals With Alcohol Problems: A Randomized Controlled Experiment

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2024-11-18
Completion: 2025-12-02
Conditions
Alcohol Abuse Harmful Alcohol Use Hazardous Alcohol Use Hazardous Drinking Risky Drinking
Interventions
OTHER
No Results Yet
NCT06671496 | RECRUITING | PHASE3
600 Participants

A Study of Zasocitinib in Adults With Psoriatic Arthritis Who Have or Have Not Been Treated With Biologic Medicines

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2025-03-10
Completion: 2027-05-18
Conditions
Psoriatic Arthritis
Interventions
DRUG
No Results Yet
NCT06670040 | RECRUITING | NA
24 Participants

Theta Burst Stimulation for Refractory Depression in Autism Spectrum Disorder

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2024-09-16
Completion: 2026-03-31
Conditions
ASD Autism Spectrum Disorder Autism Depression - Major Depressive Disorder MDD
Interventions
PROCEDURE
No Results Yet
NCT06660394 | RECRUITING | PHASE3
160 Participants

A Phase 3, Placebo-Controlled Study to Investigate LP352 in Children and Adults With Dravet Syndrome (DS)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2024-09-25
Completion: 2026-08-21
Conditions
Dravet Syndrome
Interventions
DRUG
No Results Yet
NCT06660121 | RECRUITING
30 Participants

Electrochemotherapy for Desmoid Tumors

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2024-10-17
Completion: 2028-08-01
Conditions
Desmoid Fibromatosis
Interventions
PROCEDURE
No Results Yet
NCT06656715 | RECRUITING
100 Participants

Symptom Burden and Health Related Quality of Life of Cancer Patients With Concurrent Heart Failure

Study Type: OBSERVATIONAL
Last Updated: 2025-12-23
Start Date: 2024-12-16
Completion: 2026-09-01
Conditions
Heart Failure
No Results Yet
NCT06655246 | RECRUITING | PHASE1
157 Participants

A Study of Ziftomenib, an Oral Menin Inhibitor, in Combination With Imatinib in Patients With Advanced Gastrointestinal Stromal Tumors (GIST)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2025-03-27
Completion: 2027-12-31
Conditions
Gastrointestinal Stromal Tumor (GIST) Gastrointestinal Stromal Tumor (GIST) of the Gastrointestinal Tract Gastrointestinal Stromal Cancer Gastrointestinal Stromal Neoplasm Gastrointestinal Stromal Tumor, Malignant Gastrointestinal Stromal Cell Tumors
Interventions
DRUG
No Results Yet
NCT06640985 | ACTIVE_NOT_RECRUITING | NA
43 Participants

EDX110 - Efficacy and Safety in the Management of Hard-to-heal Wounds

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2024-12-04
Completion: 2026-02-28
Conditions
Wound Healing Diabetic Foot Foot Ulcer, Diabetic Venous Ulcer
Interventions
DEVICE
No Results Yet
NCT06640972 | COMPLETED | PHASE2
68 Participants

Effects of RDX-002 on Postprandial Triglycerides in Patients Discontinuing GLP-1 Agonists

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2024-09-27
Completion: 2025-01-04
Conditions
Triglycerides Weight Gain Trajectory Cholesterol, Elevated
Interventions
DRUG
No Results Yet
NCT06635811 | RECRUITING | NA
25 Participants

Circadian Adaptive DBS in Essential Tremor

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2025-05-01
Completion: 2028-10-31
Conditions
Essential Tremor
Interventions
DEVICE
No Results Yet
NCT06634589 | RECRUITING | PHASE1/PHASE2
80 Participants

A Study to Investigate Safety and Effectiveness of BGB-16673 in Combination With Other Agents in Participants With Relapsed or Refractory B-Cell Malignancies

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2024-11-27
Completion: 2028-12-02
Conditions
B-cell Malignancy Relapsed Cancer Refractory Cancer B-cell Lymphoma
Interventions
DRUG
No Results Yet
NCT06627959 | ACTIVE_NOT_RECRUITING | NA
160 Participants

StatSeal vs Figure-of-Eight Suture for Vascular Closure in AF Ablation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2025-01-03
Completion: 2025-12-12
Conditions
Atrial Fibrillation (AF) Vascular Access
Interventions
DEVICE
No Results Yet
NCT06619509 | RECRUITING | PHASE2
90 Participants

A Study to Test Long-term Treatment With Brigimadlin in People With Solid Tumours Who Took Part in a Previous Study With This Medicine

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2024-12-30
Completion: 2030-12-30
Conditions
Solid Tumours
Interventions
DRUG
No Results Yet
NCT06618872 | RECRUITING | NA
120 Participants

Incremental Diagnostic Value of Tau-PET With [18F]RO948 vs Amyloid-PET in Patients With Cognitive Impairment

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2024-12-03
Completion: 2027-08-30
Conditions
Dementia Alzheimer Disease
Interventions
DIAGNOSTIC_TEST
No Results Yet
NCT06615492 | RECRUITING | NA
218 Participants

Routine vs On-demand ECMO for Lung Transplantation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2024-11-05
Completion: 2028-11-05
Conditions
Respiratory Failure Interstitial Lung Disease (ILD) Pulmonary Fibrosis COPD (Chronic Obstructive Pulmonary Disease)
Interventions
DEVICE
No Results Yet
NCT06613711 | ACTIVE_NOT_RECRUITING | NA
60 Participants

MagDI Italian Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-23
Start Date: 2024-09-20
Completion: 2025-06-17
Conditions
Obesity Type 2 Diabetes Mellitus (T2DM) Anastomosis
Interventions
DEVICE
No Results Yet
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