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Clinical Trials

Showing trials with last updates posted in 2025.

NCT04738812 | COMPLETED | PHASE3
1330 Participants

Determination of Adequate Tuberculosis Regimen in Patients Hospitalized With HIV-associated Severe Immune Suppression

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-04-21
Completion: 2025-11-12
Conditions
Tuberculosis HIV-1-infection Immuno-Deficiency
Interventions
DRUG
No Results Yet
NCT04725786 | COMPLETED | NA
30 Participants

Clinical Relevance of Thoracic Echography for the Early Diagnosis of Interstitial Lung Disease in Systemic Scleroderma - Pilot Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-03-17
Completion: 2022-06-08
Conditions
Systemic Sclerosis
Interventions
OTHER
No Results Yet
NCT04704401 | TERMINATED
321 Participants

Long-Term Follow-up in Patients Included in the Meta-analysis "Sleep Apnea Syndrome and Arterial Stiffness"

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2021-01-13
Completion: 2022-08-29
Conditions
Sleep Apnea
Interventions
OTHER
No Results Yet
NCT04701684 | RECRUITING | NA
594 Participants

WE-TRUST (Workflow Optimization to Reduce Time to Endovascular Reperfusion for Ultra-fast Stroke Treatment)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-06-23
Completion: 2027-04-01
Conditions
Stroke, Acute
Interventions
DEVICE PROCEDURE
No Results Yet
NCT04699630 | COMPLETED | PHASE2
121 Participants

A Study of U3-1402 (Patritumab Deruxtecan) in Subjects With Metastatic Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-05-03
Completion: 2025-04-09
Conditions
Metastatic Breast Cancer Locally Advanced Breast Cancer
Interventions
DRUG
No Results Yet
NCT04696692 | COMPLETED | NA
60 Participants

Single-Cell Map of Immune and Lymphoma Cells in B-cell Non-Hodgkin's Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-02-09
Completion: 2025-12-11
Conditions
Diffuse Large B-cell Lymphoma
Interventions
OTHER
No Results Yet
NCT04689880 | COMPLETED
75 Participants

XLIF Decade Plate System Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2021-04-12
Completion: 2023-04-01
Conditions
Degenerative Disc Disease Degenerative Spondylolisthesis Degenerative Scoliosis
No Results Yet
NCT04689854 | ENROLLING_BY_INVITATION
150 Participants

Cervical Interbody Implant Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2020-07-07
Completion: 2025-12-31
Conditions
Degenerative Disc Disease Cervical Spinal Instability
No Results Yet
NCT04684524 | COMPLETED | PHASE3
62 Participants

Dupilumab in Allergic Fungal Rhinosinusitis (AFRS) (LIBERTY-AFRS-AI)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-12-01
Completion: 2024-12-14
Conditions
Allergic Fungal Rhinosinusitis
Interventions
DRUG
Results Available
NCT04680052 | ACTIVE_NOT_RECRUITING | PHASE3
654 Participants

A Phase 3 Study to Assess Efficacy and Safety of Tafasitamab Plus Lenalidomide and Rituximab Compared to Placebo Plus Lenalidomide and Rituximab in Patients With Relapsed/Refractory (R/R) Follicular Lymphoma or Marginal Zone Lymphoma.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-04-15
Completion: 2024-02-23
Conditions
Follicular Lymphoma Marginal Zone Lymphoma
Interventions
DRUG
Results Available
NCT04675970 | COMPLETED
86 Participants

Long Term Follow up Patients With Premature Ovarian Failure ex Vivo Gene Therapy

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2020-09-01
Completion: 2024-09-30
Conditions
Primary Ovarian Insufficiency Premature Ovarian Failure
Interventions
OTHER
No Results Yet
NCT04675931 | COMPLETED | PHASE2
254 Participants

To Evaluate Efficacy, Safety, Tolerability and PK of Intravenous Cipargamin in Participants With Severe Plasmodium Falciparum Malaria

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-03-07
Completion: 2025-07-24
Conditions
Severe Malaria
Interventions
DRUG
No Results Yet
NCT04671771 | RECRUITING | NA
133 Participants

A Study to Evaluate the Safety and Effectiveness of the InnAVasc Arteriovenous Graft for Hemodialysis Access in Patients With End-Stage Renal Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-12-03
Completion: 2027-12-01
Conditions
End Stage Renal Disease (ESRD) Kidney Failure Chronic Renal Disease Hemodialysis
Interventions
DEVICE
No Results Yet
NCT04670068 | ACTIVE_NOT_RECRUITING | PHASE1
4 Participants

Phase I Study of Autologous CAR T-Cells Targeting the B7-H3 Antigen in Recurrent Epithelial Ovarian

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-01-27
Completion: 2024-12-19
Conditions
Epithelial Ovarian Cancer
Interventions
DRUG
Results Available
NCT04648228 | ACTIVE_NOT_RECRUITING | NA
157 Participants

Pain and Opioids: Integrated Treatment In Veterans

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-07-01
Completion: 2025-12-16
Conditions
Chronic Pain Opioid-use Disorder Opioids; Harmful Use
Interventions
BEHAVIORAL
No Results Yet
NCT04638647 | RECRUITING | PHASE4
1000 Participants

Secukinumab Open Label Roll-over Extension Protocol

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-12-22
Completion: 2030-01-29
Conditions
Autoimmunity, Inflammation
Interventions
BIOLOGICAL
No Results Yet
NCT04630145 | COMPLETED | PHASE2/PHASE3
129 Participants

A Study of Bedaquiline Administered as Part of a Treatment Regimen With Clarithromycin and Ethambutol in Adult Patients With Treatment-refractory Mycobacterium Avium Complex-lung Disease (MAC-LD)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-01-08
Completion: 2024-11-06
Conditions
Treatment-refractory Mycobacterium Avium Complex-lung Disease (MAC-LD)
Interventions
DRUG
No Results Yet
NCT04599270 | RECRUITING | NA
700 Participants

Efficiency of Prevention Program Dedicated to Addictive Behaviors (PREVENTURE) of Vulnerable Teenagers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-10-01
Completion: 2026-10-01
Conditions
Addiction, Alcohol Addiction, Substance
Interventions
OTHER
No Results Yet
NCT04586374 | COMPLETED
9 Participants

G- Forces On Retrieved ChildrEn Pilot Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2021-03-04
Completion: 2023-08-31
Conditions
Physiological Shock
No Results Yet
NCT04574076 | ENROLLING_BY_INVITATION
60 Participants

A Study Following Males With Haemophilia A on Prophylaxis With Esperoct®

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2020-10-23
Completion: 2027-06-03
Conditions
Haemophilia A
Interventions
DRUG
No Results Yet
NCT04562974 | COMPLETED | NA
60 Participants

Representational Approach to Hippocampal Functions : a fMRI Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-09-03
Completion: 2022-03-02
Conditions
Memory, Episodic Form Perception
Interventions
DEVICE
No Results Yet
NCT04546685 | RECRUITING | NA
110 Participants

Virtual 1-Session Spanish "Empowered Relief" Group Intervention for Chronic Pain

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-06-12
Completion: 2026-12-31
Conditions
Chronic Pain
Interventions
OTHER BEHAVIORAL
No Results Yet
NCT04537312 | ACTIVE_NOT_RECRUITING | NA
4 Participants

Prospective Pilot Study of Robot-assisted Nipple Sparing Mastectomy (RNSM)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-11-17
Completion: 2025-10-31
Conditions
Anatomic Stage I Breast Cancer AJCC v8 Anatomic Stage IA Breast Cancer AJCC v8 Anatomic Stage IB Breast Cancer AJCC v8 Anatomic Stage II Breast Cancer AJCC v8 Anatomic Stage IIA Breast Cancer AJCC v8 Anatomic Stage IIB Breast Cancer AJCC v8 Anatomic Stage IIIA Breast Cancer AJCC v8 Ductal Breast Carcinoma In Situ Prognostic Stage I Breast Cancer AJCC v8 Prognostic Stage IA Breast Cancer AJCC v8 Prognostic Stage IB Breast Cancer AJCC v8 Prognostic Stage II Breast Cancer AJCC v8 Prognostic Stage IIA Breast Cancer AJCC v8 Prognostic Stage IIB Breast Cancer AJCC v8 Prognostic Stage IIIA Breast Cancer AJCC v8 Prophylactic Mastectomy
Interventions
PROCEDURE OTHER DEVICE
No Results Yet
NCT04498078 | COMPLETED | NA
20 Participants

Creatine Supplementation in Autism Spectrum Disorder

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-01-15
Completion: 2025-05-01
Conditions
Autism Spectrum Disorder
Interventions
DIETARY_SUPPLEMENT
No Results Yet
NCT04471428 | COMPLETED | PHASE3
366 Participants

Study of Atezolizumab in Combination With Cabozantinib Versus Docetaxel in Patients With Metastatic Non-Small Cell Lung Cancer Previously Treated With an Anti-PD-L1/PD-1 Antibody and Platinum-Containing Chemotherapy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-10-01
Completion: 2022-09-28
Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG
Results Available
NCT04455074 | COMPLETED | NA
130 Participants

Validation of the Neuropsychiatric Fluctuations Scale (EFN-VALID))

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-09-23
Completion: 2023-03-23
Conditions
Parkinson Disease Fluctuating Mood Symptoms
Interventions
OTHER
No Results Yet
NCT04433065 | RECRUITING | NA
150 Participants

TTVR Early Feasibility Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-10-20
Completion: 2026-07-30
Conditions
Tricuspid Regurgitation
Interventions
DEVICE
No Results Yet
NCT04428788 | COMPLETED | PHASE1
131 Participants

Study to Evaluate the Safety and Tolerability of CC-94676 in Participants With Metastatic Castration-Resistant Prostate Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-06-22
Completion: 2025-10-28
Conditions
Prostatic Neoplasms
Interventions
DRUG
No Results Yet
NCT04422288 | COMPLETED
200 Participants

MSK Validation Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2020-05-15
Completion: 2022-10-01
Conditions
Proximal Junctional Kyphosis Spino-pelvic Alignment Thoracolumbar Spinal Fusion
No Results Yet
NCT04420143 | COMPLETED
109 Participants

MLX/XLX ACR Expandable Lumbar Interbody Implants

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2020-01-27
Completion: 2020-10-23
Conditions
Degenerative Disc Disease Spondylolisthesis Degenerative Scoliosis
No Results Yet
NCT04418830 | ENROLLING_BY_INVITATION
1050 Participants

Lumbar Interbody Implant Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2020-10-01
Completion: 2025-12-31
Conditions
Degenerative Disc Disease Degenerative Spondylolisthesis Degenerative Scoliosis Spinal Stenosis Sagittal Deformity
No Results Yet
NCT04418817 | COMPLETED
36 Participants

Modulus in XLIF Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2020-03-22
Completion: 2024-01-31
Conditions
Degenerative Scoliosis Degenerative Disc Disease Degenerative Spondylolisthesis
No Results Yet
NCT04384770 | ACTIVE_NOT_RECRUITING
179 Participants

CT-guided Stereotactic Body Radiation Therapy and MRI-guided Stereotactic Body Radiation Therapy for Prostate Cancer, MIRAGE Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2020-05-12
Completion: 2026-04-01
Conditions
Prostate Adenocarcinoma
Interventions
RADIATION OTHER
No Results Yet
NCT04358939 | COMPLETED | NA
405 Participants

Prone Position in Patients on High-flow Nasal Oxygen Therapy for COVID-19 (HIGH-PRONE-COVID-19)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-04-27
Completion: 2021-02-21
Conditions
Acute Respiratory Distress Syndrome COVID-19
Interventions
OTHER
No Results Yet
NCT04354311 | COMPLETED | NA
60 Participants

Prediction of Hemodynamic Response to Intubation by ANI Variation During Standardized Stimulation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2014-02-02
Completion: 2014-12-31
Conditions
Tracheal Intubation Morbidity Pain
Interventions
DEVICE
No Results Yet
NCT04341623 | ACTIVE_NOT_RECRUITING | NA
35 Participants

Xerosis and Use of Topical Moisturizer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-01-21
Completion: 2026-03-31
Conditions
Xerosis Due to Atopic Dermatitis
Interventions
OTHER BEHAVIORAL
No Results Yet
NCT04333745 | ACTIVE_NOT_RECRUITING | NA
22 Participants

Influence of Obesity on Oxalate Metabolism and Handling in Calcium Oxalate Stone Formers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-09-01
Completion: 2026-03-01
Conditions
Kidney Stone
Interventions
OTHER DIETARY_SUPPLEMENT
No Results Yet
NCT04322318 | RECRUITING | PHASE2
256 Participants

A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-10-19
Completion: 2027-07-01
Conditions
Anaplastic Kidney Wilms Tumor Recurrent Kidney Wilms Tumor Stage II Kidney Wilms Tumor Stage III Kidney Wilms Tumor Stage IV Kidney Wilms Tumor
Interventions
PROCEDURE DRUG RADIATION
No Results Yet
NCT04309474 | COMPLETED | PHASE2
121 Participants

A Safety and Efficacy Study of Intravenous (IV) Elezanumab Assessing Change in Neurologic Function in Adult Participants With Acute Ischemic Stroke

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-11-09
Completion: 2024-04-18
Conditions
Acute Ischemic Stroke
Interventions
DRUG
Results Available
NCT04293562 | RECRUITING | PHASE3
1186 Participants

A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-07-21
Completion: 2029-06-30
Conditions
Acute Myeloid Leukemia
Interventions
PROCEDURE DRUG OTHER
No Results Yet
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