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Clinical Trials

Showing trials with last updates posted in 2025.

NCT04670068 | ACTIVE_NOT_RECRUITING | PHASE1
4 Participants

Phase I Study of Autologous CAR T-Cells Targeting the B7-H3 Antigen in Recurrent Epithelial Ovarian

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-01-27
Completion: 2024-12-19
Conditions
Epithelial Ovarian Cancer
Interventions
DRUG
Results Available
NCT04648228 | ACTIVE_NOT_RECRUITING | NA
157 Participants

Pain and Opioids: Integrated Treatment In Veterans

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-07-01
Completion: 2025-12-16
Conditions
Chronic Pain Opioid-use Disorder Opioids; Harmful Use
Interventions
BEHAVIORAL
No Results Yet
NCT04638647 | RECRUITING | PHASE4
1000 Participants

Secukinumab Open Label Roll-over Extension Protocol

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-12-22
Completion: 2030-01-29
Conditions
Autoimmunity, Inflammation
Interventions
BIOLOGICAL
No Results Yet
NCT04630145 | COMPLETED | PHASE2/PHASE3
129 Participants

A Study of Bedaquiline Administered as Part of a Treatment Regimen With Clarithromycin and Ethambutol in Adult Patients With Treatment-refractory Mycobacterium Avium Complex-lung Disease (MAC-LD)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-01-08
Completion: 2024-11-06
Conditions
Treatment-refractory Mycobacterium Avium Complex-lung Disease (MAC-LD)
Interventions
DRUG
No Results Yet
NCT04599270 | RECRUITING | NA
700 Participants

Efficiency of Prevention Program Dedicated to Addictive Behaviors (PREVENTURE) of Vulnerable Teenagers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-10-01
Completion: 2026-10-01
Conditions
Addiction, Alcohol Addiction, Substance
Interventions
OTHER
No Results Yet
NCT04586374 | COMPLETED
9 Participants

G- Forces On Retrieved ChildrEn Pilot Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2021-03-04
Completion: 2023-08-31
Conditions
Physiological Shock
No Results Yet
NCT04574076 | ENROLLING_BY_INVITATION
60 Participants

A Study Following Males With Haemophilia A on Prophylaxis With EsperoctĀ®

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2020-10-23
Completion: 2027-06-03
Conditions
Haemophilia A
Interventions
DRUG
No Results Yet
NCT04562974 | COMPLETED | NA
60 Participants

Representational Approach to Hippocampal Functions : a fMRI Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-09-03
Completion: 2022-03-02
Conditions
Memory, Episodic Form Perception
Interventions
DEVICE
No Results Yet
NCT04546685 | RECRUITING | NA
110 Participants

Virtual 1-Session Spanish "Empowered Relief" Group Intervention for Chronic Pain

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2024-06-12
Completion: 2026-12-31
Conditions
Chronic Pain
Interventions
OTHER BEHAVIORAL
No Results Yet
NCT04537312 | ACTIVE_NOT_RECRUITING | NA
4 Participants

Prospective Pilot Study of Robot-assisted Nipple Sparing Mastectomy (RNSM)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-11-17
Completion: 2025-10-31
Conditions
Anatomic Stage I Breast Cancer AJCC v8 Anatomic Stage IA Breast Cancer AJCC v8 Anatomic Stage IB Breast Cancer AJCC v8 Anatomic Stage II Breast Cancer AJCC v8 Anatomic Stage IIA Breast Cancer AJCC v8 Anatomic Stage IIB Breast Cancer AJCC v8 Anatomic Stage IIIA Breast Cancer AJCC v8 Ductal Breast Carcinoma In Situ Prognostic Stage I Breast Cancer AJCC v8 Prognostic Stage IA Breast Cancer AJCC v8 Prognostic Stage IB Breast Cancer AJCC v8 Prognostic Stage II Breast Cancer AJCC v8 Prognostic Stage IIA Breast Cancer AJCC v8 Prognostic Stage IIB Breast Cancer AJCC v8 Prognostic Stage IIIA Breast Cancer AJCC v8 Prophylactic Mastectomy
Interventions
PROCEDURE OTHER DEVICE
No Results Yet
NCT04498078 | COMPLETED | NA
20 Participants

Creatine Supplementation in Autism Spectrum Disorder

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2022-01-15
Completion: 2025-05-01
Conditions
Autism Spectrum Disorder
Interventions
DIETARY_SUPPLEMENT
No Results Yet
NCT04471428 | COMPLETED | PHASE3
366 Participants

Study of Atezolizumab in Combination With Cabozantinib Versus Docetaxel in Patients With Metastatic Non-Small Cell Lung Cancer Previously Treated With an Anti-PD-L1/PD-1 Antibody and Platinum-Containing Chemotherapy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-10-01
Completion: 2022-09-28
Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG
Results Available
NCT04455074 | COMPLETED | NA
130 Participants

Validation of the Neuropsychiatric Fluctuations Scale (EFN-VALID))

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-09-23
Completion: 2023-03-23
Conditions
Parkinson Disease Fluctuating Mood Symptoms
Interventions
OTHER
No Results Yet
NCT04433065 | RECRUITING | NA
150 Participants

TTVR Early Feasibility Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-10-20
Completion: 2026-07-30
Conditions
Tricuspid Regurgitation
Interventions
DEVICE
No Results Yet
NCT04428788 | COMPLETED | PHASE1
131 Participants

Study to Evaluate the Safety and Tolerability of CC-94676 in Participants With Metastatic Castration-Resistant Prostate Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-06-22
Completion: 2025-10-28
Conditions
Prostatic Neoplasms
Interventions
DRUG
No Results Yet
NCT04422288 | COMPLETED
200 Participants

MSK Validation Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2020-05-15
Completion: 2022-10-01
Conditions
Proximal Junctional Kyphosis Spino-pelvic Alignment Thoracolumbar Spinal Fusion
No Results Yet
NCT04420143 | COMPLETED
109 Participants

MLX/XLX ACR Expandable Lumbar Interbody Implants

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2020-01-27
Completion: 2020-10-23
Conditions
Degenerative Disc Disease Spondylolisthesis Degenerative Scoliosis
No Results Yet
NCT04418830 | ENROLLING_BY_INVITATION
1050 Participants

Lumbar Interbody Implant Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2020-10-01
Completion: 2025-12-31
Conditions
Degenerative Disc Disease Degenerative Spondylolisthesis Degenerative Scoliosis Spinal Stenosis Sagittal Deformity
No Results Yet
NCT04418817 | COMPLETED
36 Participants

Modulus in XLIF Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2020-03-22
Completion: 2024-01-31
Conditions
Degenerative Scoliosis Degenerative Disc Disease Degenerative Spondylolisthesis
No Results Yet
NCT04384770 | ACTIVE_NOT_RECRUITING
179 Participants

CT-guided Stereotactic Body Radiation Therapy and MRI-guided Stereotactic Body Radiation Therapy for Prostate Cancer, MIRAGE Study

Study Type: OBSERVATIONAL
Last Updated: 2025-12-22
Start Date: 2020-05-12
Completion: 2026-04-01
Conditions
Prostate Adenocarcinoma
Interventions
RADIATION OTHER
No Results Yet
NCT04358939 | COMPLETED | NA
405 Participants

Prone Position in Patients on High-flow Nasal Oxygen Therapy for COVID-19 (HIGH-PRONE-COVID-19)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-04-27
Completion: 2021-02-21
Conditions
Acute Respiratory Distress Syndrome COVID-19
Interventions
OTHER
No Results Yet
NCT04354311 | COMPLETED | NA
60 Participants

Prediction of Hemodynamic Response to Intubation by ANI Variation During Standardized Stimulation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2014-02-02
Completion: 2014-12-31
Conditions
Tracheal Intubation Morbidity Pain
Interventions
DEVICE
No Results Yet
NCT04341623 | ACTIVE_NOT_RECRUITING | NA
35 Participants

Xerosis and Use of Topical Moisturizer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-01-21
Completion: 2026-03-31
Conditions
Xerosis Due to Atopic Dermatitis
Interventions
OTHER BEHAVIORAL
No Results Yet
NCT04333745 | ACTIVE_NOT_RECRUITING | NA
22 Participants

Influence of Obesity on Oxalate Metabolism and Handling in Calcium Oxalate Stone Formers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-09-01
Completion: 2026-03-01
Conditions
Kidney Stone
Interventions
OTHER DIETARY_SUPPLEMENT
No Results Yet
NCT04322318 | RECRUITING | PHASE2
256 Participants

A Study of Combination Chemotherapy for Patients With Newly Diagnosed DAWT and Relapsed FHWT

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-10-19
Completion: 2027-07-01
Conditions
Anaplastic Kidney Wilms Tumor Recurrent Kidney Wilms Tumor Stage II Kidney Wilms Tumor Stage III Kidney Wilms Tumor Stage IV Kidney Wilms Tumor
Interventions
PROCEDURE DRUG RADIATION
No Results Yet
NCT04309474 | COMPLETED | PHASE2
121 Participants

A Safety and Efficacy Study of Intravenous (IV) Elezanumab Assessing Change in Neurologic Function in Adult Participants With Acute Ischemic Stroke

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-11-09
Completion: 2024-04-18
Conditions
Acute Ischemic Stroke
Interventions
DRUG
Results Available
NCT04293562 | RECRUITING | PHASE3
1186 Participants

A Study to Compare Standard Chemotherapy to Therapy With CPX-351 and/or Gilteritinib for Patients With Newly Diagnosed AML With or Without FLT3 Mutations

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-07-21
Completion: 2029-06-30
Conditions
Acute Myeloid Leukemia
Interventions
PROCEDURE DRUG OTHER
No Results Yet
NCT04284267 | ACTIVE_NOT_RECRUITING | NA
60 Participants

Neuromodulation for Enhancement of Emotion Regulation in Bipolar Mood Disorders

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2021-03-01
Completion: 2025-10-30
Conditions
Bipolar Disorder
Interventions
DEVICE
No Results Yet
NCT04261712 | ACTIVE_NOT_RECRUITING | PHASE2
43 Participants

A Study to Evaluate the Long-Term Safety and Efficacy of Paltusotine for the Treatment of Acromegaly (ACROBAT Advance)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-01-29
Completion: 2028-03-31
Conditions
Acromegaly
Interventions
DRUG
No Results Yet
NCT04248439 | ACTIVE_NOT_RECRUITING | PHASE2
5 Participants

Gene Therapy for Fanconi Anemia, Complementation Group A

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-07-15
Completion: 2026-05-05
Conditions
Fanconi Anemia Complementation Group A
Interventions
BIOLOGICAL
No Results Yet
NCT04234646 | ACTIVE_NOT_RECRUITING | NA
600 Participants

Patient Navigation 2.0

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-12-09
Completion: 2026-05-31
Conditions
Cancer
Interventions
BEHAVIORAL
No Results Yet
NCT04234568 | ACTIVE_NOT_RECRUITING | PHASE1
31 Participants

Testing the Addition of an Anti-cancer Drug, Triapine, to the Usual Radiation-Based Treatment (Lutetium Lu 177 Dotatate) for Neuroendocrine Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-07-20
Completion: 2024-09-17
Conditions
Metastatic Digestive System Neuroendocrine Neoplasm Metastatic Neuroendocrine Tumor
Interventions
PROCEDURE DRUG
Results Available
NCT04227054 | ACTIVE_NOT_RECRUITING | NA
15 Participants

Abdominal Aortic Aneurysm Sac Healing and Prevention of Endoleaks

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-09-09
Completion: 2023-08-30
Conditions
Abdominal Aortic Aneurysm
Interventions
DEVICE
No Results Yet
NCT04200898 | COMPLETED | NA
286 Participants

Clinical Investigation of the Cheetah System For The Correction of Myopia With and Without Astigmatism

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2019-12-31
Completion: 2024-12-06
Conditions
Myopia Astigmatism
Interventions
DEVICE
No Results Yet
NCT04182204 | COMPLETED | PHASE3
270 Participants

A Study to Evaluate the Safety and Efficacy of Polatuzumab Vedotin in Combination With Rituximab, Gemcitabine and Oxaliplatin Compared to Rituximab, Gemcitabine and Oxaliplatin Alone in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-02-07
Completion: 2024-11-29
Conditions
Diffuse Large B-Cell Lymphoma
Interventions
DRUG
Results Available
NCT04175613 | COMPLETED | PHASE3
160 Participants

A Long-term Extension Study of Apremilast (CC-10004) in Pediatric Subjects From 6 Through 17 Years of Age With Moderate to Severe Plaque Psoriasis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2019-12-20
Completion: 2025-10-30
Conditions
Psoriasis
Interventions
DRUG
No Results Yet
NCT04174352 | RECRUITING | EARLY_PHASE1
12 Participants

FES Imaging to Optimize Tamoxifen for Metastatic Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2020-10-20
Completion: 2026-12-31
Conditions
ERĪ±+ Breast Cancer ESR1 Gene Mutation
Interventions
DRUG DIAGNOSTIC_TEST
No Results Yet
NCT04164199 | ENROLLING_BY_INVITATION | PHASE3
430 Participants

Study of Tislelizumab, Pamiparib, and Other Investigational Agents in Participants With Advanced Malignancies

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2019-12-19
Completion: 2026-12-31
Conditions
Advanced Malignancies
Interventions
DRUG
No Results Yet
NCT04128709 | RECRUITING | NA
50 Participants

Measurement of Bladder Pressure With a Novel External Device (Cystomanometer) - Home Use

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2019-11-19
Completion: 2026-12-31
Conditions
Urinary Bladder, Neurogenic
Interventions
DEVICE
No Results Yet
NCT04125836 | COMPLETED | PHASE3
135 Participants

A Trial to Assess the Long-term Safety of Octreotide Subcutaneous Depot in Patients With Acromegaly

Study Type: INTERVENTIONAL
Last Updated: 2025-12-22
Start Date: 2019-10-10
Completion: 2025-04-24
Conditions
Acromegaly
Interventions
DRUG
No Results Yet
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