Clinical Trials

Showing trials with last updates posted in 2025.

NCT05565560 | ACTIVE_NOT_RECRUITING | PHASE3
17 Participants

A Study to Assess the Efficacy and Safety of Apremilast in Japanese Pediatric Participants With Moderate to Severe Plaque Psoriasis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-01-25
Completion: 2025-11-20
Conditions
Plaque Psoriasis
Interventions
DRUG
No Results Yet
NCT05557201 | RECRUITING
700 Participants

Cohort of Patients Presenting Unexplained Recurrent Miscarriages and Identification of Early Miscarriage Recidivism Factors

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2022-10-24
Completion: 2027-10-31
Conditions
Miscarriage Early Pregnancy Loss
No Results Yet
NCT05556616 | TERMINATED | PHASE1
15 Participants

A Study of Modakafusp Alfa in Adult Participants With Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-01-12
Completion: 2024-06-04
Conditions
Multiple Myeloma
Interventions
DRUG
NCT05517434 | RECRUITING | PHASE2/PHASE3
148 Participants

Autologous BMA vs Saline and LAM + LP-PRP vs Saline Evaluations in Knee OA

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2025-01-01
Completion: 2026-06-30
Conditions
Osteoarthritis, Knee
Interventions
BIOLOGICAL OTHER
No Results Yet
NCT05499013 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
69 Participants

Study to Assess SLN124 in Patients With Polycythemia Vera

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-01-26
Completion: 2026-09-30
Conditions
Polycythemia Vera
Interventions
DRUG
No Results Yet
NCT05493982 | ENROLLING_BY_INVITATION | NA
10800 Participants

Evaluation of the Be Vape Free Curriculum of the Tobacco Prevention Toolkit

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-10-19
Completion: 2026-06-01
Conditions
E-cigarette Use
Interventions
BEHAVIORAL
No Results Yet
NCT05490238 | RECRUITING | NA
708 Participants

DIStal Versus COnventional Radial Access for COMPLEX Large-bore Percutaneous Coronary Intervention

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-08-31
Completion: 2026-06-01
Conditions
Vascular Access Site Occlusion
Interventions
PROCEDURE
No Results Yet
NCT05479006 | RECRUITING | NA
30 Participants

Determine the Effect of Targeted High-definition Transcranial Direct Current Stimulation (tDCS) on Reducing Post-stroke Upper Limb Motor Impairments

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-09-30
Completion: 2026-06-30
Conditions
Stroke
Interventions
DEVICE
No Results Yet
NCT05477004 | ENROLLING_BY_INVITATION
100 Participants

Observational Study of Ketamine Infusions for the Treatment of Chronic Pain

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2022-06-01
Completion: 2026-12-31
Conditions
Chronic Pain
Interventions
DRUG
No Results Yet
NCT05475002 | COMPLETED | NA
92 Participants

A Care Empowerment Program Using Virtual Reality for Family Caregivers of People With Dementia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-08-01
Completion: 2023-07-01
Conditions
Dementia Family Caregiver
Interventions
OTHER
No Results Yet
NCT05465343 | COMPLETED | PHASE2
24 Participants

Furmonertinib in EGFR-Mutant NSCLC With Brain Metastases (iFORCE)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-07-11
Completion: 2025-12-12
Conditions
Furmonertinib EGFR-mutation NSCLC Brain Metastases
Interventions
DRUG
No Results Yet
NCT05457257 | COMPLETED | PHASE4
43 Participants

Clinical Study to Assess the Efficacy and Safety of Olaparib in Chinese Patients With Metastatic Castration-Resistant Prostate Cancer Who Have Failed Prior Treatment With a New Hormonal Agent and Have BRCA1/2 Mutations

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-07-29
Completion: 2024-10-22
Conditions
Metastatic Castration-resistant Prostate Cancer
Interventions
DRUG
NCT05453500 | RECRUITING | PHASE2
30 Participants

Chemotherapy (DA-EPOCH+/-R) and Targeted Therapy (Tafasitamab) for the Treatment of Newly-Diagnosed Philadelphia Chromosome Negative B Acute Lymphoblastic Leukemia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-03-27
Completion: 2026-03-01
Conditions
B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative
Interventions
DRUG BIOLOGICAL PROCEDURE
No Results Yet
NCT05432817 | ACTIVE_NOT_RECRUITING | NA
120 Participants

PTSD Treatment for Incarcerated Men and Women: WPP

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2024-01-04
Completion: 2026-01-31
Conditions
PTSD
Interventions
BEHAVIORAL
No Results Yet
NCT05429853 | TERMINATED | NA
17 Participants

TOLER-ENT Study: A Study to Investigate the Tolerance of the High Energy, High Protein Formula Sondalis® HP 2 kcal

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-07-08
Completion: 2024-05-28
Conditions
Malnutrition
Interventions
DIETARY_SUPPLEMENT
No Results Yet
NCT05428436 | COMPLETED | PHASE1
24 Participants

A Study in Healthy People to Compare 2 Different Formulations of BI 1015550 Taken With or Without Food

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-08-15
Completion: 2022-09-30
Conditions
Healthy
Interventions
DRUG
NCT05421858 | RECRUITING | PHASE3
450 Participants

A Phase 3 Efficacy and Safety Study of Fosmanogepix for the Treatment of Adult Participants With Candidemia and/or Invasive Candidiasis.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2024-12-11
Completion: 2028-01-30
Conditions
Candidemia Candidiasis, Invasive
Interventions
DRUG
No Results Yet
NCT05407025 | ACTIVE_NOT_RECRUITING
191 Participants

Targeting Inflammation for Endometrial Cancer Prevention

Study Type: OBSERVATIONAL
Last Updated: 2025-12-19
Start Date: 2021-12-01
Completion: 2026-12-31
Conditions
Endometrial Carcinoma
Interventions
PROCEDURE OTHER
No Results Yet
NCT05388669 | ACTIVE_NOT_RECRUITING | PHASE3
418 Participants

A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Participants With Epidermal Growth Factor Receptor (EGFR)-Mutated Advanced or Metastatic Non-small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-08-05
Completion: 2024-01-03
Conditions
Advanced or Metastatic Non-small Cell Lung Cancer
Interventions
DRUG
No Results Yet
NCT05377476 | COMPLETED | NA
48 Participants

Effects of Motor Imagery and Action Observation in People With Multiple Sclerosis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-06-01
Completion: 2024-04-01
Conditions
Multiple Sclerosis
Interventions
OTHER
No Results Yet
NCT05365581 | RECRUITING | PHASE1
398 Participants

A Study of ASP2138 Given by Itself or Given With Other Cancer Treatments in Adults With Stomach Cancer, Gastroesophageal Junction Cancer, or Pancreatic Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-06-07
Completion: 2026-11-30
Conditions
Gastric Adenocarcinoma Gastroesophageal Junction (GEJ) Adenocarcinoma Pancreatic Adenocarcinoma
Interventions
DRUG
No Results Yet
NCT05357482 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
40 Participants

Addition of JSP191 (C-kit Antibody) to Nonmyeloablative Hematopoietic Cell Transplantation for Sickle Cell Disease and Beta-Thalassemia

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-05-12
Completion: 2026-01-31
Conditions
Sickle Cell Anemia Beta Thalassemia
Interventions
RADIATION DRUG BIOLOGICAL
No Results Yet
NCT05345158 | RECRUITING | NA
25 Participants

R-RPLND as First-line Treatment for Clinical Stage IIA/B Testicular Seminoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-02-23
Completion: 2030-11-30
Conditions
Lymphadenopathy Retroperitoneal Stage II Testicular Seminoma
Interventions
PROCEDURE
No Results Yet
NCT05330325 | ACTIVE_NOT_RECRUITING | PHASE3
399 Participants

A Research Study to Compare Somapacitan Once a Week With Norditropin® Once a Day in Children Who Need Help to Grow

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-08-10
Completion: 2024-08-05
Conditions
SGA, Turner Syndrome, Noonan Syndrome, ISS
Interventions
DRUG
No Results Yet
NCT05316155 | RECRUITING | PHASE1/PHASE2
262 Participants

Study of Erdafitinib Intravesical Delivery System for Localized Bladder Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-04-11
Completion: 2028-03-30
Conditions
Urinary Bladder Neoplasms Receptors, Fibroblast Growth Factor
Interventions
DRUG
No Results Yet
NCT05299658 | ACTIVE_NOT_RECRUITING | PHASE2
40 Participants

An Open-Label Extension for the Phase 2 Study in Early Symptomatic Amyotrophic Lateral Sclerosis Patients on Stable Background Therapy to Assess Bioenergetic Catalysis With CNM-Au8 to Slow Disease Progression in ALS

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2021-11-13
Completion: 2026-06-30
Conditions
Amyotrophic Lateral Sclerosis
Interventions
DRUG
No Results Yet
NCT05287594 | COMPLETED | NA
55 Participants

Feasibility of a Train-the-Trainer Delivered Exercise Intervention in Firefighters

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2023-04-01
Completion: 2025-09-26
Conditions
Firefighter High Intensity Interval Training
Interventions
BEHAVIORAL
No Results Yet
NCT05277051 | RECRUITING | PHASE1
158 Participants

First-Time-in-Human Study of GSK4381562 in Participants With Advanced Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-03-22
Completion: 2027-08-31
Conditions
Neoplasms
Interventions
DRUG
No Results Yet
NCT05276973 | ACTIVE_NOT_RECRUITING | PHASE1
25 Participants

Testing the Addition of Ipatasertib to the Usual Chemotherapy Treatment (Paclitaxel and Carboplatin) for Stage III or IV Epithelial Ovarian Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-09-08
Completion: 2025-01-30
Conditions
Fallopian Tube Endometrioid Adenocarcinoma Fallopian Tube High Grade Serous Adenocarcinoma Ovarian Endometrioid Adenocarcinoma Ovarian High Grade Serous Adenocarcinoma Primary Peritoneal Endometrioid Adenocarcinoma Primary Peritoneal High Grade Serous Adenocarcinoma Stage III Fallopian Tube Cancer AJCC v8 Stage III Ovarian Cancer AJCC v8 Stage III Primary Peritoneal Cancer AJCC v8 Stage IV Fallopian Tube Cancer AJCC v8 Stage IV Ovarian Cancer AJCC v8 Stage IV Primary Peritoneal Cancer AJCC v8 Unresectable Fallopian Tube Endometrioid Adenocarcinoma Unresectable Fallopian Tube High Grade Serous Adenocarcinoma Unresectable Ovarian Endometrioid Adenocarcinoma Unresectable Ovarian High Grade Serous Adenocarcinoma Unresectable Primary Peritoneal Endometrioid Adenocarcinoma Unresectable Primary Peritoneal High Grade Serous Adenocarcinoma
Interventions
PROCEDURE DRUG
NCT05270213 | RECRUITING | PHASE1
164 Participants

Evaluation of RBS2418 in Subjects With Advanced, Metastatic Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-07-11
Completion: 2027-04-30
Conditions
Advanced Cancer
Interventions
DRUG
No Results Yet
NCT05259839 | ACTIVE_NOT_RECRUITING | PHASE1
283 Participants

A Study to Assess Adverse Events and Change in Disease Activity of Intravenously (IV) Infused Etentamig (ABBV-383) in Combination With Anti-Cancer Regimens for the Treatment of Adult Participants With Relapsed/Refractory Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-10-20
Completion: 2033-09-30
Conditions
Relapsed/Refractory Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT05257824 | COMPLETED | PHASE4
528 Participants

Optimal Duration of Dual Antiplatelet Therapy After Stent-assisted Coiling

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-06-23
Completion: 2025-12-02
Conditions
Aneurysm Cerebral Endovascular Procedures
Interventions
DRUG
No Results Yet
NCT05249101 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
70 Participants

A Study of Ivaltinostat Plus Capecitabine or Capecitabine in Metastatic Pancreatic Adenocarcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-08-15
Completion: 2026-06-30
Conditions
Metastatic Pancreatic Adenocarcinoma
Interventions
DRUG
No Results Yet
NCT05235425 | COMPLETED | NA
304 Participants

The Lifestyle Education About Prediabetes (Leap) Study

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-03-20
Completion: 2025-11-14
Conditions
PreDiabetes
Interventions
BEHAVIORAL
No Results Yet
NCT05231785 | RECRUITING | PHASE1
60 Participants

A Study to Evaluate the Safety and Tolerability of ALN-APP in Patients With EOAD

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-02-04
Completion: 2029-03-28
Conditions
Early-Onset Alzheimer Disease
Interventions
DRUG
No Results Yet
NCT05221931 | RECRUITING | NA
1350 Participants

Drug-Coated Balloon in Patients With High Bleeding Risk

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-07-29
Completion: 2027-11-30
Conditions
Coronary Artery Disease
Interventions
PROCEDURE
No Results Yet
NCT05208710 | RECRUITING | EARLY_PHASE1
45 Participants

PANHPVAX, Study of a New HPV Vaccine in Healthy Volunteers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-11-07
Completion: 2027-12-31
Conditions
HPV
Interventions
BIOLOGICAL
No Results Yet
NCT05201469 | RECRUITING | PHASE2
74 Participants

VIBRANT: VIB4920 for Active Lupus Nephritis

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-05-16
Completion: 2026-08-31
Conditions
Lupus Nephritis
Interventions
DRUG
No Results Yet
NCT05189925 | RECRUITING | PHASE1
25 Participants

NADPH Oxidase Correction in mRNA-transfected Granulocyte-enriched Cells in Chronic Granulomatous Disease (CGD)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-07-22
Completion: 2026-07-01
Conditions
Chronic Granulomatous Disease Infection
Interventions
BIOLOGICAL
No Results Yet
NCT05178862 | TERMINATED | PHASE3
68 Participants

A Phase 3, Randomized, Double-blind Study for Patients With Invasive Candidiasis Treated With IV Echinocandin Followed by Either Oral Ibrexafungerp or Oral Fluconazole

Study Type: INTERVENTIONAL
Last Updated: 2025-12-19
Start Date: 2022-08-03
Completion: 2025-11-07
Conditions
Candidiasis, Invasive Candidemia
Interventions
DRUG
No Results Yet
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