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Clinical Trials

Showing trials with last updates posted in 2025.

NCT06968143 | RECRUITING | NA
150 Participants

Investigating Patient Satisfaction With Smart Knee Implants

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-09-01
Completion: 2027-04-30
Conditions
Total Knee Arthroplasty Knee Replacement Knee Replacement Arthroplasty Knee Osteoarthritis
Interventions
DEVICE
No Results Yet
NCT06960577 | RECRUITING | PHASE3
150 Participants

Perioperative Durvalumab With Neoadjuvant ddMVAC or Gemcitabine/Cisplatin in Patients With Muscle-invasive Bladder Cancer (NIAGARA-2)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-05-15
Completion: 2028-10-31
Conditions
Urinary Bladder Neoplasms Immune Checkpoint Inhibitors Methotrexate Vinblastine Doxorubicin Cisplatin Gemcitabine
Interventions
DRUG
No Results Yet
NCT06955013 | RECRUITING
118 Participants

Ultrasound to View Abdominal Wall Muscle Layers

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2025-08-25
Completion: 2027-12-31
Conditions
Healthy Volunteers
No Results Yet
NCT06952803 | RECRUITING | PHASE3
700 Participants

A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-08-06
Completion: 2033-03-31
Conditions
Prostate Cancer
Interventions
DRUG
No Results Yet
NCT06951698 | RECRUITING | PHASE3
274 Participants

A Study to Evaluate the Efficacy and Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-06-11
Completion: 2026-11-01
Conditions
Bipolar-I Disorder With Mania or Mania With Mixed Features
Interventions
DRUG OTHER
No Results Yet
NCT06947135 | RECRUITING | NA
166 Participants

Stellate Ganglion Morphine Infiltration on Myocardial Ischemia-Reperfusion Injury

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-05-29
Completion: 2026-06-04
Conditions
Acute Myocardial Infarction
Interventions
DRUG
No Results Yet
NCT06943755 | RECRUITING | PHASE2/PHASE3
440 Participants

Zanzalintinib Versus Everolimus in Participants With Locally Advanced or Metastatic Neuroendocrine Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-07-21
Completion: 2029-06-30
Conditions
Pancreatic Neuroendocrine Tumor (pNET) Extra-Pancreatic Neuroendocrine Tumor (epNET)
Interventions
DRUG
No Results Yet
NCT06941844 | RECRUITING | PHASE3
140 Participants

A Phase 3 Trial of MM120 for Major Depressive Disorder (Emerge)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-04-14
Completion: 2026-11-30
Conditions
Major Depressive Disorder
Interventions
OTHER DRUG
No Results Yet
NCT06940830 | RECRUITING | PHASE4
250 Participants

Long-term Study Evaluating Joint Health in People With Haemophilia A Receiving Real-world Prophylactic Treatment With Efanesoctocog Alfa

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-05-21
Completion: 2028-12-31
Conditions
Hemophilia A
Interventions
DRUG
No Results Yet
NCT06939751 | RECRUITING
250 Participants

OPtimal Adult Heart Transplant Immunosuppression With MicroRNA Levels

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2025-10-28
Completion: 2031-01-01
Conditions
Cardiac Failure Graft Rejection
No Results Yet
NCT06936878 | RECRUITING | NA
600 Participants

BOLSTER: Learning New Skills to Thrive

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-05-12
Completion: 2028-09-30
Conditions
Gastrointestinal Cancer Gynecologic Cancer Advanced Cancer
Interventions
BEHAVIORAL
No Results Yet
NCT06931886 | ENROLLING_BY_INVITATION | NA
4 Participants

Pulmonary Hypertension Inspiratory Training

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-10-25
Completion: 2026-05-31
Conditions
Pulmonary Hypertension
Interventions
OTHER
No Results Yet
NCT06931197 | NOT_YET_RECRUITING | NA
20 Participants

Why Wait? Initiating Contingency Management in Traumatically Injured Patients During Hospitalization

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2026-01-01
Completion: 2026-07-31
Conditions
Contingency Management Methamphetamine Use Disorder
Interventions
BEHAVIORAL
No Results Yet
NCT06928311 | COMPLETED | NA
25 Participants

This Study Explores Whether Adding Natural Elements Like Plants and Sunlight to Indoor Gyms Makes Exercise Feel Easier, More Enjoyable, and Improves Performance. By Comparing Workouts in Nature-inspired and Plain Gym Settings, it Aims to Find Better Ways to Design Fitness Spaces in Cities.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-04-04
Completion: 2025-10-16
Conditions
Biophilic Environmental Design Traditional Exercise Design
Interventions
OTHER
No Results Yet
NCT06926634 | RECRUITING | PHASE2
32 Participants

Zanzalintinib Maintenance in Patients With High Grade Neuroendocrine Neoplasms (HG-NENs)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-12-09
Completion: 2034-12-31
Conditions
High Grade Neuroendocrine Neoplasms
Interventions
DRUG
No Results Yet
NCT06925542 | RECRUITING | PHASE1
80 Participants

A Safety and Efficacy Study Evaluating CTX112 in Adult Subjects With Refractory Autoimmune Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-03-10
Completion: 2031-12-31
Conditions
SLE (Systemic Lupus) Lupus Erythematosus, Systemic Lupus Nephritis Systemic Sclerosis Inflammatory Myopathy, Idiopathic Myositis Diffuse Cutaneous Systemic Sclerosis
Interventions
BIOLOGICAL
No Results Yet
NCT06912009 | RECRUITING
100 Participants

Duration of Therapeutic Anticoagulation in Patients With Pulmonary Embolism

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2024-11-06
Completion: 2025-12-31
Conditions
Pulmonary Embolism
No Results Yet
NCT06911658 | RECRUITING
350 Participants

Infectious Complications After Esophagectomy

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2025-08-27
Completion: 2026-07-28
Conditions
Esophagectomy Postoperative Complications Infections Pneumonia
No Results Yet
NCT06910657 | RECRUITING | PHASE1
78 Participants

IDOV-Immune for Advanced Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-08-25
Completion: 2027-01-31
Conditions
Colorectal Cancer Pancreatic Cancer Melanoma Ovarian Cancer Gastric Cancer Esophageal Cancer Hepatocellular Carcinoma Renal Cell Carcinoma Breast Cancer Sarcoma Bladder Cancer Lung Cancer Prostate Cancer Cervical Cancers Head and Neck Cancers Adrenal Gland Tumors
Interventions
BIOLOGICAL
No Results Yet
NCT06908993 | RECRUITING | PHASE3
133 Participants

Tepotinib vs Standard Treatment in Patients With Advanced MET Exon 14 Mutated Non-Small Cell Lung Cancer Previously Treated

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-12-09
Completion: 2028-03-15
Conditions
Advanced Non Small Cell Lung Cancer MET Exon 14 Mutation
Interventions
DRUG
No Results Yet
NCT06903286 | TERMINATED | PHASE2
16 Participants

Extension Study of Participants From SPG302-ALS-001

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-05-29
Completion: 2025-06-30
Conditions
Amyotrophic Lateral Sclerosis (ALS)
Interventions
DRUG
No Results Yet
NCT06898749 | NOT_YET_RECRUITING | NA
76 Participants

Impact of Canine Mediation Practice in Psychomotor Therapy on Improving the Quality of Life in Adult Epileptic Patients.

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2026-01-31
Completion: 2029-06-30
Conditions
Epilepsy
Interventions
OTHER
No Results Yet
NCT06897202 | ACTIVE_NOT_RECRUITING | PHASE2
133 Participants

A Study to Evaluate the Efficacy and Safety of Once-Weekly MET097 in Adults With Obesity or Overweight and T2DM

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-03-14
Completion: 2025-12-31
Conditions
Obesity in Diabetes Type 2 Diabetes Mellitus (T2DM)
Interventions
DRUG
No Results Yet
NCT06896708 | RECRUITING | NA
766 Participants

Effect of Intensive Lipid-Lowering Therapy on Coronary Atherosclerotic Plaque Progression in Young and Middle-Aged Patients With Chronic Coronary Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-08-12
Completion: 2027-07-01
Conditions
Chronic Coronary Syndrome
Interventions
DRUG
No Results Yet
NCT06891352 | RECRUITING | NA
180 Participants

Optimization of Chrononutrition to Reduce the Risk of Disease in Shift Workers

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-06-02
Completion: 2028-08-31
Conditions
Night Shift Work Time Restricted Eating Overweight Obesity
Interventions
BEHAVIORAL
No Results Yet
NCT06891131 | RECRUITING
10 Participants

Implementation of an Empiric Transfusion Bundle for Out of Hospital Patients With Haemorrhagic Shock

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2025-06-01
Completion: 2027-04-01
Conditions
Haemorrhagic Shock Trauma Coagulopathy
No Results Yet
NCT06890026 | ACTIVE_NOT_RECRUITING
828 Participants

Durability of Three Monthly Loading Doses With Faricimab in Treatment-naïve Neovascular Age-related Macular Degeneration

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2024-11-15
Completion: 2025-03-09
Conditions
Neovascular Age-Related Macular Degeneration (nAMD) Treatment-naïve
Interventions
DRUG
No Results Yet
NCT06889493 | RECRUITING | PHASE1
36 Participants

SVV-001 With Nivolumab and Ipilimumab in Patients With Poorly Differentiated Neuroendocrine Carcinomas (NEC) or Well-Differentiated High-Grade Neuroendocrine Tumors (NET)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-05-19
Completion: 2030-06-01
Conditions
Neuroendocrine Carcinoma Neuroendocrine Tumors
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT06884579 | ACTIVE_NOT_RECRUITING | NA
60 Participants

Educational Programs Based on Healthy Habits to Improve Quality of Life and Psychosocial Profile in Women With Neurodegenerative Diseases: the ADVICE Protocol Study (Phase 2)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-04-15
Completion: 2025-06-15
Conditions
Multiple Sclerosis (MS) - Relapsing-remitting
Interventions
OTHER
No Results Yet
NCT06883097 | RECRUITING | NA
314 Participants

Quitting Matters Human Immunodeficiency Virus Hybrid Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-08-18
Completion: 2028-12-31
Conditions
Tobacco Tobacco Abstinence Smoking Cessation Smoking Cessation; Tobacco Dependence Human Immunodeficiency Virus (HIV) Tobacco Dependence Caused by Cigarettes Cancer Prevention
Interventions
BEHAVIORAL
No Results Yet
NCT06880861 | RECRUITING
100 Participants

Investigating Memory and Physical Activity After Cancer Treatment in Survivors of Adolescent and Young Adult Cancers

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2025-07-01
Completion: 2026-09-30
Conditions
Hematopoietic and Lymphatic System Neoplasm Malignant Solid Neoplasm
Interventions
OTHER
No Results Yet
NCT06878261 | RECRUITING | PHASE3
990 Participants

A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-03-25
Completion: 2029-03-13
Conditions
Chronic Obstructive Pulmonary Disease (COPD)
Interventions
BIOLOGICAL OTHER
No Results Yet
NCT06876896 | NOT_YET_RECRUITING | NA
50 Participants

Intra-abdominal Pressure (IAP) During PFA Treatment of A-fib/ A-Flutter

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2026-03-31
Completion: 2026-06-30
Conditions
Intra-Abdominal Hypertension
Interventions
DEVICE
No Results Yet
NCT06869850 | RECRUITING | NA
1600 Participants

Milk Fat Globule Membrane-Enhanced RUTF for Children With Severe Acute Malnutrition

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-09-22
Completion: 2027-12-01
Conditions
Severe Acute Malnutrition Cognitive Impairment Kwashiorkor Severe Wasting
Interventions
DIETARY_SUPPLEMENT DRUG
No Results Yet
NCT06869785 | RECRUITING | PHASE3
180 Participants

Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of a New Maintenance Dosing Regimen of Ofatumumab

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-03-13
Completion: 2026-12-24
Conditions
Relapsing Multiple Sclerosis (RMS)
Interventions
BIOLOGICAL
No Results Yet
NCT06868524 | RECRUITING
100 Participants

Leading Healthy Eating and Activity Promotion Program

Study Type: OBSERVATIONAL
Last Updated: 2025-12-17
Start Date: 2025-10-30
Completion: 2029-03-01
Conditions
Cancer Survivor Cancer Oncology
No Results Yet
NCT06863779 | WITHHELD

[Trial of device that is not approved or cleared by the U.S. FDA]

Last Updated: 2025-12-17
No Results Yet
NCT06859710 | RECRUITING | PHASE1
30 Participants

THC and CBD: A Controlled Human Study Probing a Harm Reduction Strategy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-11-05
Completion: 2027-09-01
Conditions
Abuse, Drug Pain
Interventions
DRUG
No Results Yet
NCT06855069 | RECRUITING | PHASE3
468 Participants

HS-20089 for Injection in Patients With Platinum-Resistant Recurrent Epithelial Ovarian Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2025-03-13
Completion: 2027-03-07
Conditions
Ovarian Cancer
Interventions
DRUG
No Results Yet
NCT06846112 | ACTIVE_NOT_RECRUITING | NA
248 Participants

Randomized Clinical Trial Aimed at Comparing Unclamped Robotic Partial Nephrectomy With or Without Renorrhaphy

Study Type: INTERVENTIONAL
Last Updated: 2025-12-17
Start Date: 2023-07-07
Completion: 2028-07-07
Conditions
Kidney Cancer
Interventions
PROCEDURE
No Results Yet
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