Clinical Trials Updated in 2025

NCT06660355 | RECRUITING | PHASE2

120 Participants

Ruxolitinib vs Prednisone as First-line Therapy for cGVHD Needing Systemic Therapy

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2024-12-23

Completion: 2028-12-31

Conditions

Chronic Graft-versus-host Disease (cGVHD)

Interventions

DRUG

No Results Yet

NCT06659965 | COMPLETED

1270 Participants

Intravenous Methocarbamol for Acute Pain After Spine Surgery

Study Type: OBSERVATIONAL

Last Updated: 2025-11-14

Start Date: 2020-01-01

Completion: 2023-12-31

Conditions

Acute Post Operative Pain Postsurgical Pain Management Spine Surgery Acute Pain, Postoperative Multimodal Analgesia

Interventions

DRUG

No Results Yet

NCT06654752 | RECRUITING | NA

430 Participants

Streamlined Treatment of Pulmonary Exacerbations in Pediatrics

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2024-12-01

Completion: 2027-12-30

Conditions

Cystic Fibrosis

Interventions

OTHER

No Results Yet

NCT06649812 | RECRUITING | PHASE2

120 Participants

Testing the Effectiveness of a Combination Targeted Therapy (ViPOR) for Patients With Relapsed and/or Refractory Aggressive B-cell Lymphoma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2025-10-07

Completion: 2027-09-01

Conditions

High Grade B-Cell Lymphoma With MYC and BCL6 Rearrangements Recurrent Diffuse Large B-Cell Lymphoma Recurrent Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Recurrent High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements Recurrent High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements Recurrent High Grade B-Cell Lymphoma, Not Otherwise Specified Recurrent T-Cell/Histiocyte-Rich Large B-Cell Lymphoma Refractory Diffuse Large B-Cell Lymphoma Refractory Diffuse Large B-Cell Lymphoma Germinal Center B-Cell Type Refractory Diffuse Large B-Cell Lymphoma, Not Otherwise Specified Refractory High Grade B-Cell Lymphoma With MYC and BCL2 or BCL6 Rearrangements Refractory High Grade B-Cell Lymphoma With MYC, BCL2, and BCL6 Rearrangements Refractory High Grade B-Cell Lymphoma, Not Otherwise Specified Refractory T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

Interventions

PROCEDURE DRUG BIOLOGICAL

No Results Yet

NCT06637631 | RECRUITING | PHASE2

260 Participants

A Study to Investigate Efficacy and Safety of SAR441566 in Patients With Crohn's Disease.

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2024-12-10

Completion: 2027-07-21

Conditions

Crohn's Disease

Interventions

DRUG

No Results Yet

NCT06636656 | ACTIVE_NOT_RECRUITING | PHASE2

45 Participants

A Study to Test Whether BI 3032950 Helps People With Ulcerative Colitis

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2024-12-11

Completion: 2026-01-19

Conditions

Ulcerative Colitis

Interventions

DRUG

No Results Yet

NCT06630299 | ACTIVE_NOT_RECRUITING | PHASE3

600 Participants

Study to Compare an Oral Weekly Islatravir/Lenacapavir Regimen With Standard of Care in Virologically Suppressed People With HIV-1

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2024-10-08

Completion: 2026-04-30

Conditions

HIV-1-Infection

Interventions

DRUG

No Results Yet

NCT06617325 | RECRUITING | PHASE3

450 Participants

A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2024-11-21

Completion: 2028-05-31

Conditions

Systemic Lupus Erythematosus

Interventions

DRUG OTHER

No Results Yet

NCT06615401 | COMPLETED

986 Participants

Understanding Perceived Access and Receipt of Gender-affirming Treatments Among Transgender Veterans

Study Type: OBSERVATIONAL

Last Updated: 2025-11-14

Start Date: 2024-10-01

Completion: 2025-01-18

Conditions

Gender Dysphoria

No Results Yet

NCT06593652 | RECRUITING | NA

615 Participants

Evaluating Caregiver Involvement in Primary Care-Based Brief Interventions for Adolescent Alcohol Use Problems

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2025-04-28

Completion: 2028-09-30

Conditions

Alcohol Use Adolescent Mild Alcohol Use Disorder Mild Substance Use Disorder

Interventions

BEHAVIORAL

No Results Yet

NCT06593236 | ACTIVE_NOT_RECRUITING

Study Type: OBSERVATIONAL

Last Updated: 2025-11-14

Start Date: 2025-10-22

Completion: 2028-09-01

Conditions

Gestational Diabetes Obesity Healthy

No Results Yet

NCT06568237 | RECRUITING | PHASE2

200 Participants

A Study to Test if TEV-56286 is Effective in Relieving Multiple System Atrophy (MSA): A Safety and Efficacy Study

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2024-10-02

Completion: 2027-05-20

Conditions

Multiple System Atrophy

Interventions

DRUG

No Results Yet

NCT06565221 | NOT_YET_RECRUITING | NA

50 Participants

Microvascular Blood Flow During Passive Heating

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2025-11-30

Completion: 2025-12-31

Conditions

Blood Flow

Interventions

DEVICE

No Results Yet

NCT06557265 | RECRUITING | PHASE1/PHASE2

96 Participants

A Phase 1/2 Study of NKX019 in Subjects With Autoimmune Disease (Ntrust-1)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2024-06-13

Completion: 2027-04-30

Conditions

Lupus Nephritis Primary Membranous Nephropathy

Interventions

DRUG

No Results Yet

NCT06556238 | RECRUITING | NA

50 Participants

Metabolism-Informed Care to Aid Alaska Native People to Quit Smoking (QUIT)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2025-11-17

Completion: 2026-06-30

Conditions

Smoking Cessation

Interventions

OTHER

No Results Yet

NCT06553872 | RECRUITING | PHASE2

60 Participants

Phase 2 Open Label Randomized Study of Pirtobrutinib and Brexucabtagene Autoleucel in R/R MCL

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2024-08-23

Completion: 2029-08-31

Conditions

Mantle Cell Lymphoma

Interventions

DRUG

No Results Yet

NCT06551506 | ACTIVE_NOT_RECRUITING | PHASE4

181 Participants

The Immunology and Safety of Maternal RSV Vaccination (ABRYSVO), Infant Nirsevimab (BEYFORTUS) Immunization, or Both Products

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2024-09-19

Completion: 2026-05-31

Conditions

Respiratory Syncytial Virus Infection

Interventions

BIOLOGICAL

No Results Yet

NCT06550141 | RECRUITING | PHASE2

28 Participants

Emapalumab Prevention of CAR-T Cell Associated Toxicities

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2024-09-18

Completion: 2026-08-01

Conditions

Large B-cell Lymphoma Relapsed Non-Hodgkin Lymphoma Refractory Non-Hodgkin Lymphoma Diffuse Large B Cell Lymphoma Primary Mediastinal Large B-cell Lymphoma High-grade B-cell Lymphoma Follicular Lymphoma

Interventions

DRUG

No Results Yet

NCT06547021 | RECRUITING | NA

100 Participants

Investigating Different Frequencies of Transcranial Electrical Stimulations in Dementia Population

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2024-09-20

Completion: 2027-08-31

Conditions

Dementia

Interventions

DEVICE

No Results Yet

NCT06546709 | ACTIVE_NOT_RECRUITING | PHASE1

55 Participants

DMID 23-0015; Lassa Fever CVD 1000

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2025-01-13

Completion: 2026-03-31

Conditions

Lassa Fever

Interventions

BIOLOGICAL OTHER

No Results Yet

NCT06545669 | RECRUITING | PHASE4

30 Participants

C-Raven, a Virtual Tobacco Cessation Intervention in the Community

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2024-10-30

Completion: 2025-12-30

Conditions

Tobacco Dependence

Interventions

BEHAVIORAL DRUG OTHER

No Results Yet

NCT06537921 | RECRUITING | NA

35 Participants

Comorbid Obesity and Depression With an Anti-inflammatory Medication

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2024-10-01

Completion: 2027-09-01

Conditions

Obesity Major Depressive Disorder Inflammation

Interventions

DRUG

No Results Yet

NCT06532773 | NOT_YET_RECRUITING | NA

60 Participants

Mindfulness Intervention for Sleep Disturbance and Symptom Management in Hematologic Cancer Patients During and After Inpatient Treatment

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2026-01-31

Completion: 2029-06-30

Conditions

Hematologic Malignancy

Interventions

BEHAVIORAL

No Results Yet

NCT06529094 | RECRUITING | NA

808 Participants

Implementing a Decision Support Tool to Prevent Community-Acquired Pressure Injury in Spinal Cord Injury (SCI) in the Spinal Cord Injury Clinic

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2024-11-01

Completion: 2027-05-31

Conditions

Spinal Cord Injury Pressure Injury

Interventions

BEHAVIORAL

No Results Yet

NCT06525636 | RECRUITING | PHASE1/PHASE2

24 Participants

A First-in-human Study of KK8123 in Adults With X-linked Hypophosphatemia

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2024-10-09

Completion: 2028-02-11

Conditions

X-linked Hypophosphatemia

Interventions

DRUG

No Results Yet

NCT06521463 | RECRUITING | NA

1857 Participants

SIMPLAAFY Clinical Trial

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2024-10-01

Completion: 2026-07-31

Conditions

Atrial Fibrillation Stroke Bleeding

Interventions

DEVICE

No Results Yet

NCT06506461 | RECRUITING | PHASE1

25 Participants

Gene Editing For Sickle Cell Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2025-03-21

Completion: 2029-12-31

Conditions

Sickle Cell Disease

Interventions

DRUG BIOLOGICAL

No Results Yet

NCT06505122 | RECRUITING | NA

60 Participants

Dyadic Life Review Intervention for Older Patients With Advanced Cancer) and Their Caregivers

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2025-05-23

Completion: 2026-01-31

Conditions

Cancer

Interventions

BEHAVIORAL

No Results Yet

NCT06499857 | RECRUITING | PHASE3

200 Participants

Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2025-04-14

Completion: 2027-12-31

Conditions

Overweight or Obesity Atrial Fibrillation

Interventions

DRUG

No Results Yet

NCT06498635 | RECRUITING | PHASE3

306 Participants

Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-Stage Non-Small Cell Lung Cancer, INSIGHT Trial

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2025-04-01

Completion: 2039-07-15

Conditions

Lung Non-Small Cell Carcinoma Stage II Lung Cancer AJCC v8 Stage IIIA Lung Cancer AJCC v8 Stage IIIB Lung Cancer AJCC v8

Interventions

PROCEDURE BIOLOGICAL OTHER

No Results Yet

NCT06497920 | RECRUITING | NA

150 Participants

rTMS to Improve Motor Function in Autism

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2024-04-24

Completion: 2029-04-30

Conditions

Autism Spectrum Disorder Motor Activity

Interventions

DEVICE

No Results Yet

NCT06496620 | RECRUITING | PHASE2

171 Participants

A Study to Evaluate Solrikitug in Participants With COPD (ZION)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2024-08-14

Completion: 2026-06-30

Conditions

COPD

Interventions

BIOLOGICAL OTHER

No Results Yet

NCT06486454 | RECRUITING

5000 Participants

Real-world Evaluation of the HistoSonics Edison System for Treatment of Liver Tumors Across Multidisciplinary Users (BOOMBOX: Master Study)

Study Type: OBSERVATIONAL

Last Updated: 2025-11-14

Start Date: 2024-10-14

Completion: 2026-11-30

Conditions

Liver Neoplasms Primary Liver Cancer Secondary Liver Cancer Tumor Liver Benign Liver Tumor

Interventions

DEVICE

No Results Yet

NCT06479811 | RECRUITING | PHASE1

120 Participants

[212Pb]VMT-Alpha-NET in Metastatic or Inoperable Somatostatin-Receptor Positive Gastrointestinal Neuroendocrine Tumors, Pheochromocytoma/Paragangliomas, Small Cell Lung, Renal Cell, and Head and Neck Cancers

Study Type: INTERVENTIONAL

Last Updated: 2025-11-14

Start Date: 2025-08-19

Completion: 2029-01-01

Conditions

Head and Neck Tumors Kidney Cancers Small Cell Lung Cancers Pheochromocytoma/Paragangliomas Gastrointestinal Neuroendocrine Tumors Somatostatin Receptor Positive

Interventions

DRUG

No Results Yet