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Clinical Trials

Showing trials with last updates posted in 2025.

NCT05909761 | RECRUITING
60 Participants

Observational Safety Study in Women With Neuromyelitis Optica Spectrum Disorder (NMOSD) Exposed to UPLIZNA® During Pregnancy

Study Type: OBSERVATIONAL
Last Updated: 2025-11-13
Start Date: 2026-01-15
Completion: 2032-10-31
Conditions
Neuromyelitis Optica Spectrum Disorder Pregnancy Related
Interventions
DRUG
No Results Yet
NCT05907122 | COMPLETED | PHASE3
256 Participants

A Study to Evaluate Similarity of ABP 206 Compared With OPDIVO® (Nivolumab) in Subjects With Resected Melanoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-07-26
Completion: 2025-10-31
Conditions
Melanoma
Interventions
DRUG
No Results Yet
NCT05904886 | ACTIVE_NOT_RECRUITING | PHASE3
687 Participants

A Study Evaluating Atezolizumab and Bevacizumab, With or Without Tiragolumab, in Participants With Untreated Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC) (IMbrave152)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-09-14
Completion: 2025-05-08
Conditions
Hepatocellular Carcinoma
Interventions
DRUG OTHER
No Results Yet
NCT05896254 | COMPLETED | PHASE1/PHASE2
55 Participants

Study of MAR001 in Adults With Metabolic Dysfunction

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-07-22
Completion: 2024-12-13
Conditions
Hypertriglyceridemia
Interventions
DRUG
No Results Yet
NCT05888441 | RECRUITING | NA
200 Participants

Obstacle Negotiation in Older People With and Without Vision Impairment

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-04-14
Completion: 2028-12-31
Conditions
Low Vision
Interventions
OTHER
No Results Yet
NCT05864846 | ACTIVE_NOT_RECRUITING | PHASE4
79 Participants

A Study to Investigate Behavioral and Other Co-Occurring Outcomes With Epidiolex as Add-On Therapy in Participants Aged 1 to 65 Years of Age With Tuberous Sclerosis Complex

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-06-29
Completion: 2026-03-26
Conditions
Tuberous Sclerosis Complex Associated Neuropsychiatric Disease
Interventions
DRUG
No Results Yet
NCT05863351 | RECRUITING | PHASE3
472 Participants

Focused Radiation Versus Systemic Therapy for Kidney Cancer Patients With Limited Metastasis, SOAR Study

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-09-07
Completion: 2030-12-01
Conditions
Metastatic Renal Cell Carcinoma Stage IV Renal Cell Cancer AJCC v8
Interventions
PROCEDURE OTHER
No Results Yet
NCT05863195 | RECRUITING | PHASE3
408 Participants

Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-10-19
Completion: 2029-06-30
Conditions
Metastatic Colorectal Carcinoma Metastatic Malignant Neoplasm in the Liver Stage IV Colorectal Cancer AJCC v8 Unresectable Colorectal Carcinoma
Interventions
BIOLOGICAL PROCEDURE DRUG
No Results Yet
NCT05862727 | ACTIVE_NOT_RECRUITING | NA
46 Participants

Preschool Attention and Sleep Support (PASS)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-07-24
Completion: 2026-01-31
Conditions
ADHD Psychiatric Health
Interventions
BEHAVIORAL
No Results Yet
NCT05839067 | RECRUITING | NA
100 Participants

Supporting Health in Veterans With Heart Failure

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-05-31
Completion: 2026-09-30
Conditions
Heart Failure
Interventions
BEHAVIORAL
No Results Yet
NCT05827081 | RECRUITING | PHASE3
1400 Participants

Phase IIIb Study of Ribociclib + ET in Early Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-02-28
Completion: 2029-09-07
Conditions
Early Breast Cancer
Interventions
DRUG
No Results Yet
NCT05820477 | ACTIVE_NOT_RECRUITING | NA
280 Participants

FAMS-T1D Self-Regulation and Social Support for T1D

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-04-25
Completion: 2027-01-31
Conditions
Type 1 Diabetes
Interventions
BEHAVIORAL
No Results Yet
NCT05815160 | ACTIVE_NOT_RECRUITING | PHASE1
34 Participants

Debio 0123 in Combination With Carboplatin and Etoposide in Adult Participants With Small Cell Lung Cancer That Recurred or Progressed After Previous Standard Platinum-Based Therapy

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-05-02
Completion: 2026-01-31
Conditions
Small Cell Lung Cancer Recurrent
Interventions
DRUG
No Results Yet
NCT05805501 | ACTIVE_NOT_RECRUITING | PHASE2
199 Participants

A Study of Immune Checkpoint Inhibitor Combinations With Axitinib in Participants With Untreated Locally Advanced Unresectable or Metastatic Renal Cell Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-04-21
Completion: 2026-07-31
Conditions
Renal Cell Carcinoma
Interventions
DRUG
No Results Yet
NCT05804318 | RECRUITING | NA
132 Participants

Daily Adaptive Radiation Therapy Using an Individualized Approach for Prostate Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-04-13
Completion: 2026-07-31
Conditions
Prostate Cancer
Interventions
DEVICE
No Results Yet
NCT05788302 | RECRUITING | NA
50 Participants

Mechanisms Underlying Efficacy of Prolonged Exposure

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-04-01
Completion: 2027-03-01
Conditions
Post Traumatic Stress Disorder
Interventions
BEHAVIORAL
No Results Yet
NCT05775159 | RECRUITING | PHASE2
294 Participants

Study of Novel Immunomodulators as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Hepatobiliary Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-04-24
Completion: 2026-10-27
Conditions
Hepatocellular Carcinoma Biliary Tract Cancer
Interventions
DRUG
No Results Yet
NCT05767658 | RECRUITING | NA
3000 Participants

Support Via Online Social Networks to Promote Safe Infant Care Practices

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-03-01
Completion: 2026-07-01
Conditions
Breastfeeding Infant Death Sudden Infant Death Syndrome Without Mention of Autopsy
Interventions
BEHAVIORAL
No Results Yet
NCT05733520 | RECRUITING | NA
160 Participants

I-CARE 2: Mobile Telehealth to Reduce Alzheimer'S-related Symptoms

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-05-30
Completion: 2027-07-30
Conditions
Caregiver Burden Alzheimer Disease
Interventions
BEHAVIORAL
No Results Yet
NCT05726487 | ACTIVE_NOT_RECRUITING | NA
224 Participants

Physical Activity Intervention for Black Women With Asthma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-05-04
Completion: 2026-07-30
Conditions
Asthma
Interventions
BEHAVIORAL OTHER
No Results Yet
NCT05724108 | RECRUITING | PHASE2
94 Participants

Testing the Effectiveness of an Anti-cancer Drug, Triapine, When Used With Targeted Radiation-based Treatment (Lutetium Lu 177 Dotatate), Compared to Lutetium Lu 177 Dotatate Alone for Metastatic Neuroendocrine Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-08-30
Completion: 2025-11-30
Conditions
Metastatic Neuroendocrine Tumor
Interventions
PROCEDURE DRUG
No Results Yet
NCT05723562 | ACTIVE_NOT_RECRUITING | PHASE2
154 Participants

A Study of Dostarlimab in Untreated dMMR/MSI-H Locally Advanced Rectal Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-04-03
Completion: 2026-11-02
Conditions
Neoplasms, Rectal
Interventions
BIOLOGICAL
No Results Yet
NCT05721755 | RECRUITING | PHASE3
290 Participants

Combining Radiation Therapy With Immunotherapy for the Treatment of Metastatic Squamous Cell Carcinoma of the Head and Neck

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-06-08
Completion: 2029-03-31
Conditions
Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 Metastatic Head and Neck Squamous Cell Carcinoma Metastatic Hypopharyngeal Squamous Cell Carcinoma Metastatic Laryngeal Squamous Cell Carcinoma Metastatic Oral Cavity Squamous Cell Carcinoma Metastatic Oropharyngeal Squamous Cell Carcinoma Stage IV Cutaneous Squamous Cell Carcinoma of the Head and Neck AJCC v8 Stage IV Hypopharyngeal Carcinoma AJCC v8 Stage IV Laryngeal Cancer AJCC v8 Stage IV Lip and Oral Cavity Cancer AJCC v8 Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8
Interventions
DRUG PROCEDURE BIOLOGICAL OTHER RADIATION
No Results Yet
NCT05721222 | TERMINATED | PHASE1/PHASE2
42 Participants

Trial of PRO1160 (GEN1160) in Relapsed or Refractory Non-Hodgkin Lymphoma (NHL) (PRO1160-001)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-03-15
Completion: 2025-11-05
Conditions
Renal Cell Carcinoma Nasopharyngeal Carcinoma Non Hodgkin Lymphoma
Interventions
BIOLOGICAL
No Results Yet
NCT05719558 | RECRUITING | PHASE1
210 Participants

A Study of ASP1002 in Adults for Treatment of Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-03-13
Completion: 2028-04-30
Conditions
Advanced Solid Tumors
Interventions
DRUG
No Results Yet
NCT05714085 | RECRUITING | PHASE2/PHASE3
342 Participants

Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Left Ventricular Systolic Dysfunction (MK-1242-036)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-05-31
Completion: 2032-04-15
Conditions
Heart Failure Left Ventricular Systolic Dysfunction
Interventions
DRUG
No Results Yet
NCT05710328 | RECRUITING | PHASE2
235 Participants

Testing the Role of FDG-PET/CT to Predict Response to Therapy Prior to Surgery for HER2-positive Breast Cancer, The DIRECT Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-05-10
Completion: 2027-05-31
Conditions
Anatomic Stage II Breast Cancer AJCC v8 Anatomic Stage III Breast Cancer AJCC v8 HER2-Positive Breast Carcinoma Invasive Breast Carcinoma
Interventions
DRUG PROCEDURE OTHER
No Results Yet
NCT05704478 | ACTIVE_NOT_RECRUITING | PHASE4
30 Participants

Impact of Vericiguat on Hemodynamics of Heart Failure

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-01-01
Completion: 2026-03-31
Conditions
Heart Failure
Interventions
DRUG
No Results Yet
NCT05664789 | RECRUITING | PHASE2/PHASE3
144 Participants

Targeting the Neurobiology of RRB in Autism Using N-acetylcysteine: Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-04-26
Completion: 2026-01-31
Conditions
Autism Spectrum Disorder
Interventions
DRUG
No Results Yet
NCT05661461 | RECRUITING | PHASE1
28 Participants

Dose-escalation Study to Assess Safety and Pharmacokinetics of Nab-Sirolimus in Patients With Locally Advanced or Metastatic Solid Tumors and Moderate Liver Impairment

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2022-11-23
Completion: 2026-06-01
Conditions
Tumor, Solid Tumor Advanced Solid Tumor
Interventions
DRUG
No Results Yet
NCT05650749 | RECRUITING | PHASE1
45 Participants

GPC2 CAR T Cells for Relapsed or Refractory Neuroblastoma and Metastatic Retinoblastoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-05-23
Completion: 2028-01-30
Conditions
Refractory Neuroblastoma Relapsed Neuroblastoma High-risk Neuroblastoma Retinoblastoma Metastatic Retinoblastoma
Interventions
BIOLOGICAL
No Results Yet
NCT05650632 | RECRUITING | PHASE1
180 Participants

A Study to Assess Adverse Events of Intravenously (IV) Infused ABBV-383 in Adult Participants With Relapsed or Refractory Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-03-21
Completion: 2029-08-31
Conditions
Multiple Myeloma
Interventions
DRUG
No Results Yet
NCT05641844 | RECRUITING | NA
110 Participants

A Double Blind, Randomized Controlled Study, Evaluating the Safety and Efficacy of RD2 Ver.02 For the Management of Anal Fistulas

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-01-20
Completion: 2027-12-31
Conditions
Anal Fistula
Interventions
DEVICE OTHER
No Results Yet
NCT05640843 | RECRUITING | NA
150 Participants

A Study Comparing a Plant-Based Diet With Supplements and Placebo in People With Monoclonal Gammopathy of Undetermined Significance (MGUS) or Smoldering Multiple Myeloma (SMM)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2022-11-29
Completion: 2026-11-30
Conditions
Monoclonal Gammopathy of Undetermined Significance Smoldering Multiple Myeloma
Interventions
OTHER DIETARY_SUPPLEMENT
No Results Yet
NCT05630183 | ACTIVE_NOT_RECRUITING | PHASE2
81 Participants

A Study of Botensilimab in Participants With Metastatic Pancreatic Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-03-27
Completion: 2025-12-05
Conditions
Metastatic Pancreatic Ductal Adenocarcinoma
Interventions
DRUG
No Results Yet
NCT05607095 | RECRUITING | PHASE1
20 Participants

A Study of LN-144 or LN-145 in People With Advanced Uveal Melanoma, Undifferentiated Pleomorphic Sarcoma, or Dedifferentiated Liposarcoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2022-11-01
Completion: 2026-05-01
Conditions
Uveal Melanoma Melanoma Metastatic Uveal Melanoma Metastatic Melanoma
Interventions
BIOLOGICAL
No Results Yet
NCT05582187 | COMPLETED | PHASE1
28 Participants

A Clinical Trial of the Study Medicine (Called Fosmanogepix) in Participants With Varying Degrees of Hepatic Function.

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2022-10-31
Completion: 2025-10-16
Conditions
Hepatic Impairment
Interventions
DRUG
No Results Yet
NCT05564390 | RECRUITING | PHASE2
2000 Participants

MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2024-06-18
Completion: 2029-05-15
Conditions
Acute Myeloid Leukemia Myelodysplastic Syndrome
Interventions
PROCEDURE DRUG OTHER RADIATION
No Results Yet
NCT05564377 | RECRUITING | PHASE2
2900 Participants

Targeted Therapy Directed by Genetic Testing in Treating Patients With Locally Advanced or Advanced Solid Tumors, The ComboMATCH Screening Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-11-13
Start Date: 2023-04-07
Completion: 2030-07-01
Conditions
Advanced Malignant Solid Neoplasm Anatomic Stage III Breast Cancer AJCC v8 Anatomic Stage IV Breast Cancer AJCC v8 Locally Advanced Malignant Solid Neoplasm Malignant Female Reproductive System Neoplasm Metastatic HER2-Negative Breast Carcinoma Metastatic Malignant Solid Neoplasm Recurrent Endometrial Carcinoma Recurrent Fallopian Tube Carcinoma Recurrent Malignant Female Reproductive System Neoplasm Recurrent Malignant Solid Neoplasm Recurrent Ovarian Carcinoma Recurrent Primary Peritoneal Carcinoma Unresectable HER2-Negative Breast Carcinoma Unresectable Malignant Solid Neoplasm
Interventions
DRUG PROCEDURE BIOLOGICAL
No Results Yet
NCT05562895 | COMPLETED
155 Participants

A Multicenter Study to Evaluate the Cios Spin and the Ion Endoluminal System for Pulmonary Nodule Biopsy

Study Type: OBSERVATIONAL
Last Updated: 2025-11-13
Start Date: 2022-12-31
Completion: 2023-12-31
Conditions
Lung Cancer
Interventions
DEVICE
No Results Yet
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