Clinical Trials
Showing trials with last updates posted in 2025.
1450
Participants
Testing the Use of Combination Therapy in Adult Patients With Newly Diagnosed Multiple Myeloma, the EQUATE Trial
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-02-24
Completion:
2027-12-31
Conditions
Plasma Cell Myeloma
RISS Stage I Plasma Cell Myeloma
RISS Stage II Plasma Cell Myeloma
Interventions
DRUG
BIOLOGICAL
OTHER
No Results Yet
230
Participants
Enhancing Geriatric Pain Care
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2023-02-01
Completion:
2025-09-30
Conditions
Pain
Interventions
OTHER
No Results Yet
186
Participants
Comparison of Chemotherapy Before and After Surgery Versus After Surgery Alone for the Treatment of Gallbladder Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-02-24
Completion:
2029-06-30
Conditions
Stage II Gallbladder Cancer AJCC v8
Stage IIA Gallbladder Cancer AJCC v8
Stage IIB Gallbladder Cancer AJCC v8
Stage III Gallbladder Cancer AJCC v8
Stage IIIA Gallbladder Cancer AJCC v8
Stage IIIB Gallbladder Cancer AJCC v8
Interventions
DRUG
PROCEDURE
No Results Yet
308
Participants
A Study of Combination Amivantamab and Carboplatin-Pemetrexed Therapy, Compared With Carboplatin-Pemetrexed, in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer Characterized by Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertions
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2020-10-13
Completion:
2023-05-03
Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG
350
Participants
A Clinical Trial Investigating the Safety, Tolerability, and Therapeutic Effects of BNT113 in Combination With Pembrolizumab Versus Pembrolizumab Alone for Patients With a Form of Head and Neck Cancer Positive for Human Papilloma Virus 16 and Expressing the Protein PD-L1
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-01-07
Completion:
2029-04-30
Conditions
Unresectable Head and Neck Squamous Cell Carcinoma
Metastatic Head and Neck Cancer
Recurrent Head and Neck Cancer
Interventions
BIOLOGICAL
No Results Yet
700
Participants
Biomarkers and Clinical Features of Metastatic Breast Cancer in Patients Treated With CDK4/6 Inhibitors
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-13
Start Date:
2020-07-03
Completion:
2030-07-03
Conditions
Anatomic Stage IV Breast Cancer AJCC v8
Metastatic Breast Carcinoma
Prognostic Stage IV Breast Cancer AJCC v8
Interventions
OTHER
No Results Yet
434
Participants
Efficacy and Safety of the Aflibercept FYB203 Biosimilar in Comparison to Eylea® in Patients With Neovascular Age-Related Macular Degeneration
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2020-07-21
Completion:
2022-06-23
Conditions
Neovascular Age-related Macular Degeneration
Interventions
DRUG
281
Participants
A Study of Subcutaneous Blinatumomab Administration in Participants With R/R and MRD+ B-ALL
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-01-04
Completion:
2027-07-27
Conditions
B Cell Precursor Acute Lymphoblastic Leukemia
Interventions
DRUG
No Results Yet
45
Participants
Safety Aid Reduction Treatment for PTSD Among Veterans
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2024-09-23
Completion:
2025-09-29
Conditions
Stress Disorders, Post-Traumatic
Interventions
BEHAVIORAL
No Results Yet
12
Participants
Iomab-ACT: A Pilot Study of 131-I Apamistamab Followed by CD19-Targeted CAR T-Cell Therapy for Patients With Relapsed or Refractory B-Cell Acute Lymphoblastic Leukemia or Diffuse Large B-Cell Lymphoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-02-02
Completion:
2027-01-31
Conditions
B-ALL
DLBCL
B ALL
Dlbcl-Ci
DLBCL Unclassifiable
DLBCL, Nos Genetic Subtypes
DLBCL Activated B-Cell Type
DLBCL Germinal Center B-Cell Type
Diffuse Large B-cell Lymphoma
HGBL
HGBL, Nos
Interventions
DRUG
BIOLOGICAL
No Results Yet
1074
Participants
A Study of Amivantamab and Lazertinib Combination Therapy Versus Osimertinib in Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2020-09-30
Completion:
2023-08-11
Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG
27
Participants
Testing the Addition of Darolutamide to Hormonal Therapy (Androgen Deprivation Therapy [ADT]) After Surgery for Men With High-Risk Prostate Cancer, The ERADICATE Study
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-03-01
Completion:
2026-06-30
Conditions
Prostate Carcinoma
Interventions
DRUG
OTHER
No Results Yet
61
Participants
Cancer and Blood Pressure Management, CARISMA Study
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2020-10-29
Completion:
2026-08-31
Conditions
Chronic Kidney Disease
Metastatic Renal Cell Carcinoma
Metastatic Thyroid Gland Medullary Carcinoma
Stage IV Renal Cell Cancer AJCC v8
Stage IV Thyroid Gland Medullary Carcinoma AJCC v8
Stage IVA Thyroid Gland Medullary Carcinoma AJCC v8
Stage IVB Thyroid Gland Medullary Carcinoma AJCC v8
Stage IVC Thyroid Gland Medullary Carcinoma AJCC v8
Cardiovascular Disorder
Interventions
OTHER
No Results Yet
150
Participants
Using Biomarkers to Help Guide Safe Immunotherapy Discontinuation in Patients With Unresectable Stage IIIB-IV Melanoma, The PET-Stop Trial
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-02-09
Completion:
2026-08-29
Conditions
Advanced Melanoma
Clinical Stage III Cutaneous Melanoma AJCC v8
Clinical Stage IV Cutaneous Melanoma AJCC v8
Melanoma of Unknown Primary
Pathologic Stage IIIB Cutaneous Melanoma AJCC v8
Pathologic Stage IIIC Cutaneous Melanoma AJCC v8
Pathologic Stage IIID Cutaneous Melanoma AJCC v8
Pathologic Stage IV Cutaneous Melanoma AJCC v8
Unresectable Acral Lentiginous Melanoma
Unresectable Melanoma
Unresectable Mucosal Melanoma
Interventions
BIOLOGICAL
OTHER
No Results Yet
134
Participants
Targeting Sleep Homeostasis to Improve Alcohol Use Disorder Treatment Outcomes (M-STAR Study)
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2020-11-12
Completion:
2026-02-28
Conditions
Insomnia
Alcohol Use Disorder
Interventions
BEHAVIORAL
No Results Yet
350
Participants
DB RCT for Specialized Phototherapy in Parkinson's Disease.
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2024-02-26
Completion:
2026-06-30
Conditions
Parkinson Disease
Interventions
DEVICE
No Results Yet
804
Participants
Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2020-10-08
Completion:
2032-12-31
Conditions
Biochemically Recurrent Prostate Carcinoma
Metastatic Prostate Carcinoma
Prostate Adenocarcinoma
Stage IVB Prostate Cancer AJCC v8
Interventions
RADIATION
DRUG
PROCEDURE
OTHER
No Results Yet
320
Participants
Evaluation of the Efficacy and Safety of DMR Using the Revita® in Subjects With Inadequately Controlled Type 2 Diabetes
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-03-08
Completion:
2026-01-31
Conditions
Type 2 Diabetes
Interventions
DEVICE
No Results Yet
351
Participants
Study of LAU-7b for the Treatment of Coronavirus Disease 2019 (COVID-19) Disease in Adults
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2020-08-18
Completion:
2024-02-15
Conditions
COVID-19 Disease
Interventions
DRUG
138
Participants
Testing the Addition of Radiation Therapy to the Usual Immune Therapy Treatment (Atezolizumab) for Extensive Stage Small Cell Lung Cancer, The RAPTOR Trial
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-01-07
Completion:
2027-04-30
Conditions
Extensive Stage Lung Small Cell Carcinoma
Interventions
DRUG
PROCEDURE
RADIATION
No Results Yet
30
Participants
Matched Related and Unrelated Donor Stem Cell Transplantation for Severe Combined Immune Deficiency (SCID): Busulfan-based Conditioning With h-ATG, Radiation, and Sirolimus
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2025-11-18
Completion:
2026-09-09
Conditions
Severe Combined Immune Deficiency (SCID)
Interventions
DRUG
RADIATION
No Results Yet
1650
Participants
Isolating and Mitigating Sequentially Dependent Perceptual Errors in Clinical Visual Search
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2019-04-01
Completion:
2031-06-30
Conditions
Vision
Interventions
BEHAVIORAL
No Results Yet
138
Participants
Using FDG-PET/CT to Assess Response of Bone-Dominant Metastatic Breast Cancer, FEATURE Study
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2020-09-15
Completion:
2027-08-31
Conditions
Anatomic Stage IV Breast Cancer AJCC v8
Hormone Receptor Positive Breast Carcinoma
Metastatic Breast Carcinoma
Prognostic Stage IV Breast Cancer AJCC v8
Interventions
PROCEDURE
OTHER
No Results Yet
98
Participants
Fatty Acid Supplementation in Children With ASD (Study 2)
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-12-01
Completion:
2023-11-28
Conditions
Autism Spectrum Disorder
Interventions
DRUG
DIETARY_SUPPLEMENT
385
Participants
Adjusted Brodalumab Dose Compared With Standard Brodalumab Dose in Subjects With Moderate-to-severe Plaque Psoriasis and ≥120 kg Body Weight
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2022-08-16
Completion:
2025-08-25
Conditions
Psoriasis Vulgaris
Interventions
BIOLOGICAL
No Results Yet
247
Participants
Testing Early Treatment for Patients With High-Risk Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL), EVOLVE CLL/SLL Study
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-03-02
Completion:
2028-10-01
Conditions
Chronic Lymphocytic Leukemia
Small Lymphocytic Lymphoma
Interventions
PROCEDURE
BIOLOGICAL
OTHER
DRUG
No Results Yet
45
Participants
MitoQ for Fatigue in Multiple Sclerosis (MS)
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2020-04-01
Completion:
2024-10-15
Conditions
Multiple Sclerosis
Fatigue
Interventions
DRUG
1210
Participants
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2020-06-16
Completion:
2025-12-15
Conditions
Lung Non-Small Cell Carcinoma
Lung Non-Small Cell Squamous Carcinoma
Lung Non-Squamous Non-Small Cell Carcinoma
Stage II Lung Cancer AJCC v8
Stage IIIA Lung Cancer AJCC v8
Stage IIIB Lung Cancer AJCC v8
Interventions
PROCEDURE
DRUG
OTHER
BIOLOGICAL
No Results Yet
2175
Participants
CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2020-03-13
Completion:
2026-10-31
Conditions
Anatomic Stage II Breast Cancer AJCC v8
Anatomic Stage IIA Breast Cancer AJCC v8
Anatomic Stage IIB Breast Cancer AJCC v8
Anatomic Stage IIIA Breast Cancer AJCC v8
Invasive Breast Carcinoma
Prognostic Stage II Breast Cancer AJCC v8
Prognostic Stage IIA Breast Cancer AJCC v8
Prognostic Stage IIB Breast Cancer AJCC v8
Prognostic Stage IIIA Breast Cancer AJCC v8
Interventions
DRUG
PROCEDURE
BIOLOGICAL
RADIATION
No Results Yet
173
Participants
Sleep-disordered Breathing in Infants With Myelomeningocele
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-13
Start Date:
2020-07-21
Completion:
2024-04-25
Conditions
Sleep-disordered Breathing
Myelomeningocele
Interventions
DIAGNOSTIC_TEST
No Results Yet
314
Participants
Testing the Addition of Radiotherapy to the Usual Treatment (Chemotherapy) for Patients With Esophageal and Gastric Cancer That Has Spread to a Limited Number of Other Places in the Body
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2020-05-26
Completion:
2028-03-31
Conditions
Clinical Stage IV Esophageal Adenocarcinoma AJCC v8
Clinical Stage IV Gastric Cancer AJCC v8
Clinical Stage IVA Esophageal Adenocarcinoma AJCC v8
Clinical Stage IVA Gastric Cancer AJCC v8
Clinical Stage IVB Esophageal Adenocarcinoma AJCC v8
Clinical Stage IVB Gastric Cancer AJCC v8
Metastatic Esophageal Adenocarcinoma
Metastatic Gastric Adenocarcinoma
Oligometastatic Esophageal Adenocarcinoma
Oligometastatic Gastric Adenocarcinoma
Pathologic Stage IV Esophageal Adenocarcinoma AJCC v8
Pathologic Stage IV Gastric Cancer AJCC v8
Pathologic Stage IVA Esophageal Adenocarcinoma AJCC v8
Pathologic Stage IVB Esophageal Adenocarcinoma AJCC v8
Interventions
DRUG
RADIATION
No Results Yet
560
Participants
Peer Support For Young Adult Women With High Breast Cancer Risk
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2020-07-15
Completion:
2026-04-30
Conditions
Breast Cancer Risk
Interventions
BEHAVIORAL
No Results Yet
4606
Participants
Comparing Two Methods to Follow Patients With Pancreatic Cysts
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2020-06-16
Completion:
2037-06-03
Conditions
Pancreatic Carcinoma
Interventions
PROCEDURE
OTHER
No Results Yet
176
Participants
Comparing Two Treatment Combinations, Gemcitabine and Nab-Paclitaxel With 5-Fluorouracil, Leucovorin, and Liposomal Irinotecan for Older Patients With Pancreatic Cancer That Has Spread
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2020-08-26
Completion:
2026-06-30
Conditions
Metastatic Pancreatic Adenocarcinoma
Stage IV Pancreatic Cancer AJCC v8
Interventions
DRUG
OTHER
No Results Yet
162
Participants
Open-Label Extension of Voxelotor
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2019-11-18
Completion:
2024-11-01
Conditions
Sickle Cell Disease
Interventions
DRUG
419
Participants
A Study Comparing JNJ-68284528, a CAR-T Therapy Directed Against B-cell Maturation Antigen (BCMA), Versus Pomalidomide, Bortezomib and Dexamethasone (PVd) or Daratumumab, Pomalidomide and Dexamethasone (DPd) in Participants With Relapsed and Lenalidomide-Refractory Multiple Myeloma
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2020-06-12
Completion:
2024-05-01
Conditions
Multiple Myeloma
Interventions
DRUG
252
Participants
Lower-Dose Chemoradiation in Treating Patients With Early-Stage Anal Cancer, the DECREASE Study
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2020-01-02
Completion:
2029-12-31
Conditions
Anal Basaloid Carcinoma
Anal Canal Cloacogenic Carcinoma
Anal Canal Squamous Cell Carcinoma
Anal Margin Squamous Cell Carcinoma
Stage I Anal Cancer AJCC v8
Stage IIA Anal Cancer AJCC v8
Interventions
PROCEDURE
DRUG
OTHER
RADIATION
No Results Yet
54
Participants
Closed-loop Optimized rTMS for Depression
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2021-06-01
Completion:
2025-08-30
Conditions
Major Depressive Disorder
Interventions
DEVICE
No Results Yet
18
Participants
Use of High-resolution Manometry to Detect Upper Airway Obstruction During Sleep
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-13
Start Date:
2019-01-16
Completion:
2021-05-05
Conditions
Obstructive Sleep Apnea
Interventions
PROCEDURE
No Results Yet
5
Participants
Stimulation Combined With Powered Motorized Orthoses for Walking After Stroke
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-13
Start Date:
2020-04-01
Completion:
2026-11-01
Conditions
Stroke
Hemiparesis
Interventions
DEVICE
No Results Yet
Showing 40 trials per page · Total 107726 trials