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Clinical Trials

Showing trials with last updates posted in 2025.

NCT07092865 | RECRUITING | PHASE2
208 Participants

A Study Evaluating Persistence of the Immune Response of the Adjuvanted Respiratory Syncytial Virus (RSV) Vaccine and the Safety and Immune Response Following Revaccination in Adults 18 Years of Age and Above Who Received Lung or Kidney Transplant

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-08-06
Completion: 2027-01-12
Conditions
Respiratory Syncytial Virus Infections
Interventions
BIOLOGICAL
No Results Yet
NCT07091695 | COMPLETED
100 Participants

Real-world Outcomes Among Patients With Melanoma Treated With Neoadjuvant Nivolumab+Relatlimab or Nivolumab+Ipilimumab

Study Type: OBSERVATIONAL
Last Updated: 2025-11-12
Start Date: 2025-05-11
Completion: 2025-11-06
Conditions
Melanoma
Interventions
BIOLOGICAL
No Results Yet
NCT07086976 | RECRUITING | PHASE3
90 Participants

A Study to Investigate the Efficacy, Safety, and Pharmacokinetics of Oral Rilzabrutinib Compared With Placebo in Participants 18 Years of Age and Older With Warm Autoimmune Hemolytic Anemia

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-08-18
Completion: 2028-05-31
Conditions
Autoimmune Haemolytic Anaemia
Interventions
DRUG
No Results Yet
NCT07085338 | RECRUITING | PHASE2
54 Participants

A Phase II Study With a Safety Run-In of the Addition of N-803 to a Chemoimmunotherapy Backbone for the Treatment of Patients With Relapsed or Refractory Neuroblastoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-10
Completion: 2028-02-01
Conditions
Neuroblastoma Recurrent
Interventions
DRUG
No Results Yet
NCT07085325 | NOT_YET_RECRUITING
184 Participants

CSIMEMPHIS: Long-term Follow-up of Medulloblastoma Survivors That Received Craniospinal Irradiation

Study Type: OBSERVATIONAL
Last Updated: 2025-11-12
Start Date: 2025-12-31
Completion: 2030-10-31
Conditions
Medulloblastoma
No Results Yet
NCT07084168 | RECRUITING | NA
30 Participants

Multimedia Aid for Genetic Testing in Gynecologic Oncology

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2024-10-10
Completion: 2026-10-30
Conditions
Ovary Cancer Endometrial Cancer
Interventions
BEHAVIORAL
No Results Yet
NCT07076485 | RECRUITING | PHASE2
768 Participants

Shortening Adjuvant Photon and Proton Irradiation (SAPPHIRe-II): A 4 Cohort, Randomized, Phase II Multi-center Trial Evaluating Shorter Schedules of Adjuvant Regional Nodal Irradiation Among Women and Men With Node-positive and High-risk Node-negative Invasive Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-08-19
Completion: 2029-01-01
Conditions
Breast Cancer
Interventions
RADIATION
No Results Yet
NCT07076212 | RECRUITING | PHASE2
52 Participants

Evaluating NALIRIFOX vs Modified Gemcitabine, Nab-Paclitaxel and Cisplatin in Patients With Locally Advanced and Metastatic Pancreatic Adenocarcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-07
Completion: 2028-05-31
Conditions
Metastatic Pancreatic Adenocarcinoma Locally Advanced Pancreatic Adenocarcinoma
Interventions
DRUG
No Results Yet
NCT07071623 | RECRUITING | PHASE3
4580 Participants

A Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-010)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-10
Completion: 2027-10-18
Conditions
Human Immunodeficiency Virus (HIV) HIV Pre-Exposure Prophylaxis
Interventions
DRUG
No Results Yet
NCT07071519 | RECRUITING | PHASE3
120 Participants

A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-07-28
Completion: 2034-07-31
Conditions
Ulcerative Colitis
Interventions
DRUG
No Results Yet
NCT07067151 | ENROLLING_BY_INVITATION
30 Participants

Using Smartwatches to Monitor Smoking in Real-life Situations

Study Type: OBSERVATIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-17
Completion: 2026-04-30
Conditions
Smoking
No Results Yet
NCT07067138 | NOT_YET_RECRUITING | NA
175 Participants

A Synthetic Lethality-Focused Algorithm to Identify Therapeutic Options in Advanced Metastatic Breast Cancer (SYNTHESIS-Breast)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-17
Completion: 2027-08-04
Conditions
Breast Cancer Breast Carcinoma Cancer of the Breast Malignant Neoplasm of Breast
Interventions
DEVICE
No Results Yet
NCT07065240 | RECRUITING | PHASE2
360 Participants

A Study to Evaluate the Efficacy and Safety of SPT-300 (GlyphAllo) in Participants With Major Depressive Disorder, With or Without Anxious Distress (BUOY-1 Study)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-06-19
Completion: 2027-03-31
Conditions
Major Depressive Disorder (MDD) Major Depressive Disorder With Anxious Distress
Interventions
DRUG
No Results Yet
NCT07064473 | RECRUITING | PHASE3
11800 Participants

A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-07-22
Completion: 2029-12-14
Conditions
Diabetes Mellitus, Type 2 Hypertension Cardiovascular Diseases
Interventions
DRUG
No Results Yet
NCT07063745 | RECRUITING | PHASE2/PHASE3
590 Participants

A Study to Compare the Combination of BMS-986504 With Pembrolizumab and Chemotherapy Versus Placebo Plus Pembrolizumab and Chemotherapy in First-line Metastatic Non-small Cell Lung Cancer Participants With Homozygous MTAP Deletion

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-28
Completion: 2031-08-12
Conditions
Metastatic Non-small Cell Lung Cancer With MTAP Deletion
Interventions
DRUG OTHER
No Results Yet
NCT07063654 | COMPLETED | NA
17 Participants

Mobile Health Program for Teens With Congenital Heart Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-07-17
Completion: 2025-11-02
Conditions
Congenital Heart Disease in Adolescence Health Behavior
Interventions
BEHAVIORAL
No Results Yet
NCT07061977 | RECRUITING | PHASE3
336 Participants

Induction Pembrolizumab and Chemotherapy Followed by Pembrolizumab Before Chemoradiation and Pembrolizumab Maintenance Compared to Standard Chemoradiation With Pembrolizumab Followed by Pembrolizumab Maintenance in High-Risk Cervical Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-05
Completion: 2030-12-31
Conditions
Locally Advanced Cervical Adenocarcinoma Locally Advanced Cervical Adenosquamous Carcinoma Locally Advanced Cervical Squamous Cell Carcinoma Stage IIIA Cervical Cancer FIGO 2018 Stage IIIB Cervical Cancer FIGO 2018 Stage IIIC1 Cervical Cancer FIGO 2018 Stage IIIC2 Cervical Cancer FIGO 2018 Stage IVA Cervical Cancer FIGO 2018
Interventions
PROCEDURE RADIATION DRUG BIOLOGICAL
No Results Yet
NCT07061964 | RECRUITING | PHASE2
111 Participants

Combining Immunotherapy and Radiation Therapy to Help Patients Avoid Bladder Removal After Treatment Shrinks Muscle Invasive Bladder Cancer, BRIGHT Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2026-06-01
Completion: 2027-07-31
Conditions
Muscle Invasive Bladder Urothelial Carcinoma Stage II Bladder Cancer AJCC v8 Stage IIIA Bladder Cancer AJCC v8
Interventions
PROCEDURE BIOLOGICAL RADIATION OTHER
No Results Yet
NCT07060807 | RECRUITING | PHASE3
1000 Participants

A Clinical Study of Patritumab Deruxtecan to Treat Breast Cancer (MK-1022-016)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-07-21
Completion: 2033-07-14
Conditions
Breast Neoplasms
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT07059962 | RECRUITING
125 Participants

Sensor-based Congestion ALert for Events in Peritoneal Dialysis (SCALE-PD)

Study Type: OBSERVATIONAL
Last Updated: 2025-11-12
Start Date: 2025-09-09
Completion: 2026-06-30
Conditions
Kidney Disease Peritoneal Dialysis (PD) End Stage Kidney Disease (ESRD)
Interventions
DEVICE
No Results Yet
NCT07058077 | RECRUITING | PHASE2/PHASE3
153 Participants

A Study of Enlicitide Decanoate (MK-0616, an Oral PCSK9 Inhibitor) in Children and Adolescents With Heterozygous Familial Hypercholesterolemia (MK-0616-029)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-08-21
Completion: 2033-12-04
Conditions
Heterozygous Familial Hypercholesterolemia (HeFH)
Interventions
DRUG
No Results Yet
NCT07054190 | RECRUITING | PHASE2
60 Participants

A Study to Test Inavolisib Treatments in Participants With Early-Stage, PIK3CA-Mutated Breast Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-09-09
Completion: 2027-07-31
Conditions
Breast Cancer
Interventions
DRUG
No Results Yet
NCT07054008 | RECRUITING | NA
25 Participants

Microsurgery and Periodontal Healing

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-08-31
Completion: 2027-05-31
Conditions
Periodontal Diseases
Interventions
PROCEDURE
No Results Yet
NCT07053969 | RECRUITING | NA
32 Participants

The Effect Of Enamel Matrix Derivatives On Gingival Tissue Thickness

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-08-31
Completion: 2027-09-30
Conditions
Dental Implantation Missing Teeth Periodontitis, Adult Mucositis
Interventions
DEVICE
No Results Yet
NCT07053774 | RECRUITING | PHASE2
24 Participants

Intranasal and Intravenous Oxytocin for Analgesia to Noxious Heat Pain

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-05
Completion: 2026-09-30
Conditions
Pain, Acute
Interventions
DRUG
No Results Yet
NCT07050160 | ENROLLING_BY_INVITATION
10 Participants

Long-term Follow-up Study of Gene Therapy for Arrhythmogenic Cardiomyopathy Due to a Plakophilin-2 Pathogenic Variant

Study Type: OBSERVATIONAL
Last Updated: 2025-11-12
Start Date: 2025-08-29
Completion: 2030-08-31
Conditions
Arrhythmogenic Cardiomyopathy PKP2-ACM PKP2-ARVC
No Results Yet
NCT07049848 | NOT_YET_RECRUITING | PHASE2
50 Participants

SATURN-STS: Phase II Study of Neoadjuvant Atezolizumab With Doxorubicin, Concurrent Atezolizumab With Pre-operative Radiation Therapy and Adjuvant Atezolizumab in Patients With High-risk Surgically Resectable Extremity and Truncal Soft Tissue Sarcoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-12-01
Completion: 2028-01-01
Conditions
Soft Tissue Sarcoma
Interventions
DRUG
No Results Yet
NCT07048535 | RECRUITING
80 Participants

CAR T-cell Long-Term Follow-Up, Quality of Life and Adverse Reactions

Study Type: OBSERVATIONAL
Last Updated: 2025-11-12
Start Date: 2025-10-24
Completion: 2028-07-31
Conditions
B-Cell Acute Lymphoblastic Leukemia (B-ALL)
No Results Yet
NCT07047716 | RECRUITING | PHASE3
300 Participants

Study of Lenacapavir as a Once-Yearly Injection for HIV Pre-exposure Prophylaxis (PrEP)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-07-22
Completion: 2028-09-30
Conditions
HIV Pre-exposure Prophylaxis
Interventions
DRUG
No Results Yet
NCT07046819 | NOT_YET_RECRUITING | PHASE2
120 Participants

Tirzepatide in MetALD

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-17
Completion: 2026-07-30
Conditions
Metabolic Alcohol-associated Liver Disease Alcohol Use Disorder
Interventions
DRUG OTHER
No Results Yet
NCT07044297 | RECRUITING | PHASE3
4390 Participants

A Clinical Study of MK-8527 to Prevent Human Immunodeficiency Virus Type 1 (HIV-1) (MK-8527-011)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-07-31
Completion: 2027-07-22
Conditions
Human Immunodeficiency Virus (HIV) HIV Pre-Exposure Prophylaxis
Interventions
DRUG
No Results Yet
NCT07043452 | WITHDRAWN | EARLY_PHASE1
0 Participants

Measuring Acute Drug Demand in Humans II

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-15
Completion: 2027-12-01
Conditions
Healthy Volunteers
Interventions
DRUG
No Results Yet
NCT07043400 | RECRUITING | PHASE3
351 Participants

A Study to Investigate Tislelizumab Administered as Subcutaneous Injection Versus Intravenous Infusion Plus Chemotherapy in Patients With Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-08-27
Completion: 2027-10-30
Conditions
Metastatic Gastric Adenocarcinoma Gastroesophageal Junction Adenocarcinoma
Interventions
DRUG
No Results Yet
NCT07042386 | NOT_YET_RECRUITING | NA
144 Participants

Implementation of a Beauty Salon-Based Strategy for Blood Pressure Management Among Women

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-12-01
Completion: 2028-05-31
Conditions
Hypertension
Interventions
BEHAVIORAL
No Results Yet
NCT07039630 | RECRUITING | NA
50 Participants

A Food Security Intervention for the Prevention of Cancer in Low-income Families

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-12-01
Completion: 2026-10-30
Conditions
Obesity-Related Malignant Neoplasm
Interventions
BEHAVIORAL OTHER
No Results Yet
NCT07028853 | RECRUITING | PHASE3
1000 Participants

This Study Will Explore Whether a Combination of the Investigational Drug Mevrometostat (PF-06821497) and Enzalutamide Will Work Better Than Taking Enzalutamide Alone in Participants With mCSPC Who Are ARPI naïve.

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-09-28
Completion: 2028-09-12
Conditions
Metastatic Castration Sensitive Prostate Cancer (mCSPC) Hormone Sensitive Prostate Cancer Prostate Cancer Cancer of the Prostate
Interventions
DRUG
No Results Yet
NCT07027839 | RECRUITING | PHASE1
30 Participants

Acute Effects of Alcohol on PET Imaging of Phosphodiesterase-4B (PDE4B)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-17
Completion: 2028-02-22
Conditions
Alcohol Use Disorder
Interventions
DRUG
No Results Yet
NCT07027826 | RECRUITING | NA
70 Participants

The Esophageal String Test as a Diagnostic Screening Tool for Eosinophilic Esophagitis Among Africans With Dysphagia in Mali and the United States

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-17
Completion: 2027-08-31
Conditions
Dysphagia Eosinophilic Esophagitis
Interventions
DEVICE
No Results Yet
NCT07026942 | NOT_YET_RECRUITING | PHASE1/PHASE2
42 Participants

Phase I/II Clinical Trial of Universal Donor CD33 CAR Natural Killer Cells for AML

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2026-04-01
Completion: 2032-07-01
Conditions
Relapsed/Refractory AML
Interventions
BIOLOGICAL
No Results Yet
NCT07025538 | NOT_YET_RECRUITING | PHASE1
42 Participants

Biomarker-Guided Ruxolitinib for the Prevention of Chronic Graft Versus Host Disease After Allogeneic Hematopoietic Cell Transplantation

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-12-09
Completion: 2028-04-05
Conditions
Hematopoietic and Lymphatic System Neoplasm
Interventions
OTHER PROCEDURE DRUG
No Results Yet
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