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Clinical Trials

Showing trials with last updates posted in 2025.

NCT06930755 | RECRUITING | PHASE1
24 Participants

Study of NMS-03305293 in Adult Patients With Relapsed Ovarian Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-12-31
Completion: 2027-05-31
Conditions
Ovarian Cancer
Interventions
DRUG
No Results Yet
NCT06929273 | RECRUITING | PHASE3
450 Participants

A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-07-18
Completion: 2028-06-13
Conditions
Bipolar Disorder Type I With Mania
Interventions
DRUG
No Results Yet
NCT06926660 | RECRUITING | PHASE2
416 Participants

A Study to Test Whether Vicadrostat in Combination With Empagliflozin Helps People With Chronic Kidney Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-07-18
Completion: 2027-01-08
Conditions
Chronic Kidney Disease
Interventions
DRUG
No Results Yet
NCT06923072 | RECRUITING | PHASE2
12 Participants

Baricitinib in the Treatment of Kohlmeier-Degos Disease in Patients With Neurological Involvement

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-17
Completion: 2030-12-14
Conditions
Kohlmeier-Degos Disease Malignant Atrophic Papulosis Degos Disease Papulosis, Malignant Atrophic
Interventions
DRUG
No Results Yet
NCT06921837 | RECRUITING | PHASE1/PHASE2
122 Participants

A First-in-Human Study Using BDC-4182 as a Single Agent in Advanced Gastric and Gastroesophageal Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-05-26
Completion: 2027-05-31
Conditions
Gastric Cancer Adenocarcinoma Metastatic Gastroesophageal Adenocarcinoma
Interventions
DRUG
No Results Yet
NCT06918067 | RECRUITING | NA
17 Participants

Comparison of Urinary Flow Study

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-06
Completion: 2026-12-31
Conditions
Urinary Retention
Interventions
DEVICE
No Results Yet
NCT06916221 | RECRUITING | NA
150 Participants

BID LTM Digital Intervention in Aging

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-08-20
Completion: 2027-12-31
Conditions
Long-Term Memory Inhibitory Control
Interventions
BEHAVIORAL
No Results Yet
NCT06914609 | RECRUITING | PHASE3
210 Participants

REVEAL: A Phase 3 Study of ION582 in Angelman Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-06-10
Completion: 2027-08-31
Conditions
Angelman Syndrome
Interventions
DRUG
No Results Yet
NCT06911931 | RECRUITING | NA
84 Participants

Visual Perception in Schizophrenia

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-03
Completion: 2027-01-31
Conditions
Schizophrenia Disorders Bipolar Disorder Schizo Affective Disorder
Interventions
OTHER
No Results Yet
NCT06906809 | COMPLETED | PHASE1
37 Participants

Effect of Phenytoin or Itraconazole on How BGB-16673 is Absorbed and Removed From the Body in Healthy Participants

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-04-03
Completion: 2025-10-13
Conditions
Healthy Volunteers
Interventions
DRUG
No Results Yet
NCT06906640 | RECRUITING | NA
1170 Participants

Implementation pRogram to Improve Screening and Management for CKD in Diabetes (IRIS-CKD) (Program 2)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-10-28
Completion: 2027-04-01
Conditions
Chronic Kidney Disease(CKD) Type 2 DM Type 2 Diabetes Mellitus (T2DM)
Interventions
OTHER
No Results Yet
NCT06906627 | RECRUITING | NA
800 Participants

Implementation pRogram to Improve Screening and Management for CKD in Diabetes (Program 1) (IRIS-CKD)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-10-28
Completion: 2027-04-01
Conditions
Chronic Kidney Disease(CKD) Type 2 DM Type 2 Diabetes Mellitus (T2DM)
Interventions
OTHER
No Results Yet
NCT06904066 | RECRUITING | PHASE1
86 Participants

Autologous T Cells Transduced With Retroviral Vectors Expressing TCRs for Participant-specific Neoantigens in Patients With Hematologic Malignancies

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-17
Completion: 2029-04-30
Conditions
Malignancy, Hematologic Neoplasms, Hematologic Neoplasms, Hematopoietic Blood Cancer Hematological Neoplasms Hematopoietic Malignancies Dysmyelopoietic Syndromes Hematopoetic Myelodysplasia Myeloid Leukemia, Acute Nonlymphoblastic Leukemia, Acute Leukemia, Lymphocytic, Acute
Interventions
DRUG BIOLOGICAL DEVICE
No Results Yet
NCT06900595 | RECRUITING | PHASE2
48 Participants

Testing the Addition of an Anti-Cancer Drug, Cabozantinib to the Immunotherapy Drug Cemiplimab (REGN2810), in Adolescents and Adults With Advanced Adrenocortical Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2026-07-19
Completion: 2029-06-02
Conditions
Locally Advanced Adrenal Cortical Carcinoma Metastatic Adrenal Cortical Carcinoma Recurrent Adrenal Cortical Carcinoma Stage III Adrenal Cortical Carcinoma AJCC v8 Stage IV Adrenal Cortical Carcinoma AJCC v8 Unresectable Adrenal Cortical Carcinoma
Interventions
PROCEDURE DRUG BIOLOGICAL
No Results Yet
NCT06894511 | RECRUITING | PHASE2
420 Participants

An Open-label Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan (AAA617) in Combination With ARPI Versus AAA617 in PSMA Positive First-line mCRPC

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-09-11
Completion: 2029-04-09
Conditions
Metastatic Castration Resistant Prostate Cancer (mCRPC)
Interventions
DRUG
No Results Yet
NCT06892548 | RECRUITING | PHASE1/PHASE2
594 Participants

A Clinical Study to Investigate the Efficacy and Safety of an Investigational Combination Therapy With BNT324 and BNT327 in Patients With Advanced Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-05-02
Completion: 2027-08-31
Conditions
Advanced Lung Cancer
Interventions
BIOLOGICAL
No Results Yet
NCT06892288 | RECRUITING | PHASE2/PHASE3
50 Participants

A Study to Assess the Efficacy and Safety of Weekly Doses of GLM101 in Participants With PMM2-CDG

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-07-09
Completion: 2026-01-31
Conditions
Phosphomannomutase 2 Deficiency PMM2-CDG
Interventions
DRUG
No Results Yet
NCT06890884 | RECRUITING | PHASE2
594 Participants

A Clinical Study of Zilovertamab Vedotin (MK-2140) Plus Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Polatuzumab Vedotin Plus R-CHP in People With Diffuse Large B-cell Lymphoma (DLBCL) (MK-2140-011/waveLINE-011)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-04-11
Completion: 2027-12-13
Conditions
Lymphoma, Large B-Cell, Diffuse
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT06887972 | ACTIVE_NOT_RECRUITING | PHASE4
100 Participants

A Single-Arm Study Evaluating the Effectiveness and Safety of Suzetrigine (SUZ) for Acute Pain After Aesthetic or Reconstructive Surgeries

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-03-21
Completion: 2025-10-24
Conditions
Acute Pain
Interventions
DRUG
No Results Yet
NCT06884449 | COMPLETED | NA
135 Participants

A Placebo-Controlled Study Evaluating the Effects of Arrabina P on Satiety in Healthy Adults

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-04-15
Completion: 2025-10-28
Conditions
Satiety Appetite Regulation Weight Control
Interventions
DIETARY_SUPPLEMENT OTHER
No Results Yet
NCT06882785 | RECRUITING | PHASE3
250 Participants

A Study to Evaluate the Efficacy and Safety of KarXT in Acutely Psychotic Japanese Adult Participants With Schizophrenia

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-06-10
Completion: 2028-09-23
Conditions
Schizophrenia
Interventions
DRUG OTHER
No Results Yet
NCT06881784 | RECRUITING | PHASE3
420 Participants

Study of Daraxonrasib (RMC-6236) in Patients With RAS Mutated NSCLC (RASolve 301)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-05-06
Completion: 2027-12-01
Conditions
NSCLC (Non-small Cell Lung Cancer) Non-Small Cell Lung Cancer NSCLC NSCLC (Non-small Cell Lung Carcinoma) NSCLC (Advanced Non-small Cell Lung Cancer)
Interventions
DRUG
No Results Yet
NCT06880744 | RECRUITING | PHASE3
530 Participants

A Study to Assess the Change in Disease Activity in Adult Participants With Moderate to Severe Ulcerative Colitis Treated With Risankizumab Compared to Vedolizumab

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-06-17
Completion: 2028-09-30
Conditions
Ulcerative Colitis
Interventions
DRUG
No Results Yet
NCT06878365 | RECRUITING | PHASE1
18 Participants

A Study to Test How Well BI 3000202 is Tolerated by People With Type 1 Interferonopathies

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-07-29
Completion: 2026-12-06
Conditions
Type 1 Interferonopathies
Interventions
DRUG
No Results Yet
NCT06876142 | RECRUITING | PHASE1/PHASE2
54 Participants

Combination Therapy (Mirdametinib and Sirolimus) for RAS Mutated Relapsed Refractory Multiple Myeloma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-17
Completion: 2033-01-01
Conditions
Multiple Myeloma Relapsed and/or Refractory Multiple Myeloma (RRMM)
Interventions
DRUG
No Results Yet
NCT06872125 | RECRUITING | PHASE3
150 Participants

A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in Patients With Dravet Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-06-04
Completion: 2027-03-31
Conditions
Dravet Syndrome
Interventions
DRUG OTHER
No Results Yet
NCT06869447 | NOT_YET_RECRUITING | NA
100 Participants

New York Better Breathing Study

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-15
Completion: 2028-03-15
Conditions
Localized Lung Carcinoma Stage I Lung Cancer AJCC v8 Stage II Lung Cancer AJCC v8 Stage III Lung Cancer AJCC v8
Interventions
PROCEDURE OTHER
No Results Yet
NCT06868914 | RECRUITING | PHASE1
35 Participants

Phase I Trial of High-Density Theta Burst Stimulation (hdTBS)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-17
Completion: 2028-01-13
Conditions
Healthy Volunteers
Interventions
DEVICE
No Results Yet
NCT06866405 | RECRUITING | PHASE3
550 Participants

A Phase 3 Study of Revaccination in Subsequent Pregnancies With Bivalent RSV Vaccine and Duration of Protection of a Single Dose

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-04-16
Completion: 2028-02-24
Conditions
RSV Infection
Interventions
BIOLOGICAL
No Results Yet
NCT06864169 | RECRUITING | PHASE2
160 Participants

A Study of Raludotatug Deruxtecan (R-DXd) in People With Gastrointestinal Cancers (MK-5909-005)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-04-01
Completion: 2026-07-06
Conditions
Gastrointestinal Cancer
Interventions
BIOLOGICAL
No Results Yet
NCT06863272 | RECRUITING | PHASE1/PHASE2
360 Participants

A Clinical Study of Ifinatamab Deruxtecan Based Treatment Combinations or as Monotherapy to Treat Metastatic Castrate Resistant Prostate Cancer (mCRPC) (MK-2400-01A/IDeate-Prostate02)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-07-03
Completion: 2030-02-18
Conditions
Castration-Resistant Prostatic Cancer Metastasis
Interventions
DRUG
No Results Yet
NCT06861790 | RECRUITING | NA
120 Participants

WISE-2B Brain Study (Weight Loss Intervention Surgical Effects on Brain Function)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-10
Completion: 2027-12-31
Conditions
Diabetes Weight Loss
Interventions
BEHAVIORAL PROCEDURE
No Results Yet
NCT06860607 | RECRUITING | PHASE1
44 Participants

Environment and Alcohol: A Pilot Study

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-17
Completion: 2027-03-01
Conditions
Alcohol Use Disorder
Interventions
BEHAVIORAL
No Results Yet
NCT06860386 | RECRUITING | PHASE2
75 Participants

Study of Adaptive Immunotherapy With VEGFR-TKI in Patients With Advanced RCC

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-02-25
Completion: 2028-02-29
Conditions
Renal Cell Carcinoma Clear Cell Renal Cell Carcinoma
Interventions
DRUG
No Results Yet
NCT06856226 | RECRUITING
88 Participants

Natural History Study to Determine Drug Metabolism Phenotype and Appropriate Germline Source DNA in Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant

Study Type: OBSERVATIONAL
Last Updated: 2025-11-12
Start Date: 2025-11-17
Completion: 2027-12-01
Conditions
Leukemia Lymphoma Hematologic Malignancy
Interventions
OTHER
No Results Yet
NCT06855277 | RECRUITING | PHASE3
605 Participants

Study Comparing AAA817+ARPI Versus Standard of Care in Adult Participants With PSMA-positive mCRPC

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-07-01
Completion: 2028-02-29
Conditions
Prostate Cancer
Interventions
DRUG
No Results Yet
NCT06846671 | RECRUITING | PHASE3
250 Participants

A Study of BGB-16673 Compared to Investigator's Choice in Participants With Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma Previously Exposed to Both Bruton Tyrosine Kinase (BTK) and B-cell Leukemia/Lymphoma 2 Protein (BCL2) Inhibitors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-04-10
Completion: 2028-05-15
Conditions
CLL Chronic Lymphocytic Leukemia
Interventions
DRUG
No Results Yet
NCT06846320 | RECRUITING | PHASE2
315 Participants

Study to Assess Adverse Events and Change in Disease Activity When Oral ABBV-932 is Added to Antidepressant Therapies in Adult Participants With Generalized Anxiety Disorder

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-04-29
Completion: 2026-11-30
Conditions
Generalized Anxiety Disorder (GAD)
Interventions
DRUG
No Results Yet
NCT06845202 | RECRUITING | PHASE1/PHASE2
144 Participants

A Study to Evaluate ALN-4324 in Overweight to Obese Healthy Volunteers and in Overweight to Obese Patients With T2DM

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-03-03
Completion: 2027-08-31
Conditions
Obese or Overweight Healthy Volunteers Type 2 Diabetes Mellitus (T2DM)
Interventions
DRUG
No Results Yet
NCT06843967 | RECRUITING | PHASE1/PHASE2
54 Participants

A Study of Mirdametinib in Combination With Palbociclib in People With Liposarcoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2025-02-19
Completion: 2028-08-19
Conditions
Well Differentiated Liposarcoma Dedifferentiated Liposarcoma Liposarcoma Myxoid Liposarcoma Round Cell Liposarcoma Myxoid Pleomorphic Liposarcoma Pleomorphic Liposarcoma Unresectable Liposarcoma Unresectable Dedifferentiated Liposarcoma
Interventions
DRUG
No Results Yet
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