Clinical Trials Updated in 2025

NCT06191484 | RECRUITING | NA

169 Participants

Risk and Resilience to Suicide Following Late-Life Spousal Bereavement

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-11-20

Completion: 2028-12-31

Conditions

Suicide Bereavement

Interventions

BEHAVIORAL

No Results Yet

NCT06189807 | ACTIVE_NOT_RECRUITING | NA

70 Participants

Pregnancy and Contraception Education in Chronic Kidney Disease (PACE-CKD)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-02-14

Completion: 2025-09-24

Conditions

CKD Chronic Kidney Diseases

Interventions

BEHAVIORAL OTHER

No Results Yet

NCT06176365 | ACTIVE_NOT_RECRUITING | PHASE3

274 Participants

A Study to Test Whether Survodutide Helps Japanese People Living With Obesity Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-01-16

Completion: 2025-12-03

Conditions

Obesity

Interventions

DRUG

No Results Yet

NCT06173804 | ACTIVE_NOT_RECRUITING | NA

20 Participants

Multilevel Lifestyle Intervention to Improve Physical Function in Older Adults With Type 2 Diabetes

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-07-22

Completion: 2025-05-23

Conditions

Type 2 Diabetes

Interventions

OTHER

No Results Yet

NCT06172296 | RECRUITING | PHASE3

478 Participants

Dinutuximab With Chemotherapy, Surgery and Stem Cell Transplantation for the Treatment of Children With Newly Diagnosed High Risk Neuroblastoma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-04-19

Completion: 2029-12-31

Conditions

Ganglioneuroblastoma, Nodular Neuroblastoma

Interventions

PROCEDURE DRUG BIOLOGICAL RADIATION OTHER

No Results Yet

NCT06164951 | ACTIVE_NOT_RECRUITING | PHASE3

110 Participants

A Study to Evaluate the Efficacy and Safety of Infigratinib in Children and Adolescents With Achondroplasia

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-11-10

Completion: 2025-12-31

Conditions

Achondroplasia

Interventions

DRUG

No Results Yet

NCT06152575 | RECRUITING | PHASE3

492 Participants

MagnetisMM-32: A Study to Learn About the Study Medicine Called Elranatamab in People With Multiple Myeloma (MM) That Has Come Back After Taking Other Treatments (Including Prior Treatment With an Anti-CD38 Antibody and Lenalidomide)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-02-08

Completion: 2026-08-30

Conditions

Multiple Myeloma

Interventions

DRUG

No Results Yet

NCT06150417 | RECRUITING | PHASE2

200 Participants

MDRT in Prostate Cancer Treated With Long-term Androgen Deprivation Therapy in the STAMPEDE Trial (METANOVA)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-07-01

Completion: 2028-04-01

Conditions

Prostate Cancer Malignant Neoplasm of Prostate Secondary Malignant Neoplasm of Prostate

Interventions

DRUG OTHER RADIATION

No Results Yet

NCT06139328 | ACTIVE_NOT_RECRUITING | PHASE2

160 Participants

IRI-EXPLORE: A Study to Test Whether BI 765845 Helps People Who Have Had a Heart Attack

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-12-05

Completion: 2025-09-02

Conditions

Myocardial Infarction

Interventions

DRUG

No Results Yet

NCT06136624 | RECRUITING | PHASE3

1310 Participants

Study of Opevesostat (MK-5684) Versus Alternative NHA in mCRPC (MK-5684-003)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-12-31

Completion: 2028-08-02

Conditions

Prostate Cancer Metastatic

Interventions

DRUG

No Results Yet

NCT06133634 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

70 Participants

Fisetin to Improve Vascular Function in Older Adults

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-09-25

Completion: 2026-03-31

Conditions

Aging Endothelial Dysfunction Arterial Stiffness

Interventions

DIETARY_SUPPLEMENT OTHER

No Results Yet

NCT06132113 | RECRUITING | PHASE1

55 Participants

DAREON™-7: A Study to Test How Well Different Doses of BI 764532 in Addition to Chemotherapy Are Tolerated by People With Advanced Neuroendocrine Cancers

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-01-22

Completion: 2027-02-09

Conditions

Neuroendocrine Neoplasms

Interventions

DRUG

No Results Yet

NCT06128928 | RECRUITING | NA

900 Participants

Connecting Friends and Health Workers to Boost COVID-19 Vaccination in Latino Communities

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-07-08

Completion: 2026-12-31

Conditions

COVID-19 Vaccine

Interventions

BEHAVIORAL

No Results Yet

NCT06127407 | RECRUITING | PHASE3

136 Participants

Ivosidenib in Participants With Locally Advanced or Metastatic Conventional Chondrosarcoma Untreated or Previously Treated With 1 Systemic Treatment Regimen

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-07-09

Completion: 2028-02-01

Conditions

Locally Advanced or Metastatic Conventional Chondrosarcoma With an IDH1 Mutation, Untreated or Previously Treated With 1 Systemic Treatment Regimen

Interventions

DRUG

No Results Yet

NCT06126276 | RECRUITING | PHASE2

70 Participants

Testing the Use of Neratinib or the Combination of Neratinib and Palbociclib Targeted Treatment for HER2+ Solid Tumors (A ComboMATCH Treatment Trial)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-05-07

Completion: 2027-02-20

Conditions

Malignant Female Reproductive System Neoplasm Malignant Solid Neoplasm Recurrent Malignant Female Reproductive System Neoplasm Recurrent Malignant Solid Neoplasm

Interventions

PROCEDURE DRUG

No Results Yet

NCT06124157 | RECRUITING | PHASE3

222 Participants

A Study Testing the Combination of Dasatinib or Imatinib to Chemotherapy Treatment With Blinatumomab for Children, Adolescents, and Young Adults With Philadelphia Chromosome Positive (Ph+) or ABL-Class Philadelphia Chromosome-Like (Ph-Like) B-cell Acute Lymphoblastic Leukemia (B-ALL)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2025-05-30

Completion: 2030-12-01

Conditions

B Acute Lymphoblastic Leukemia

Interventions

PROCEDURE BIOLOGICAL DRUG RADIATION

No Results Yet

NCT06123195 | RECRUITING | NA

40 Participants

Effects of Constipation Treatment in Chronic Kidney Disease: A Pilot Feasibility Trial

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-02-01

Completion: 2025-11-17

Conditions

Chronic Kidney Disease Constipation

Interventions

OTHER

No Results Yet

NCT06122935 | COMPLETED | NA

6735 Participants

Evaluation of the Aurora Xi New Nomogram Software 2.0

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-11-27

Completion: 2024-04-19

Conditions

Apheresis Related Hypotension

Interventions

DEVICE

Results Available

NCT06121297 | RECRUITING | PHASE1/PHASE2

12 Participants

RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-02-16

Completion: 2027-12-31

Conditions

Systemic Lupus Erythematosus Lupus Nephritis

Interventions

BIOLOGICAL

No Results Yet

NCT06117891 | RECRUITING

300 Participants

An Observational Study to Learn More About How Well a Treatment Works When Given After Treatment With Atezolizumab and Bevacizumab or Another Similar Combination of Drugs in Adults With Liver Cancer That Cannot be Treated With Surgery

Study Type: OBSERVATIONAL

Last Updated: 2025-11-12

Start Date: 2023-11-27

Completion: 2026-11-27

Conditions

Unresectable Hepatocellular Carcinoma

Interventions

DRUG

No Results Yet

NCT06112418 | RECRUITING | NA

7500 Participants

A Randomized Comparison of Stage-Based Care Versus Risk Factor-Based Care for Prevention of Cardiovascular Events

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-03-06

Completion: 2029-03-05

Conditions

Diabetes Mellitus, Type 2 PreDiabetes Metabolic Syndrome

Interventions

DEVICE

No Results Yet

NCT06109181 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

10 Participants

Gene Therapy for ACM Due to a PKP2 Pathogenic Variant

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-02-29

Completion: 2026-12-31

Conditions

Arrhythmogenic Cardiomyopathy PKP2-ACM PKP2-ARVC

Interventions

GENETIC

No Results Yet

NCT06098079 | RECRUITING | PHASE4

8600 Participants

Effect of Naltrexone Hydrochloride ER and Bupropion Hydrochloride ER Combination (Contrave®/Mysimba®) on Major Adverse Cardiovascular Events (MACE)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-01-03

Completion: 2029-01-31

Conditions

Obesity

Interventions

DRUG

No Results Yet

NCT06095505 | RECRUITING | PHASE2

80 Participants

A Study of Alisertib in Patients With Extensive Stage Small Cell Lung Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-02-08

Completion: 2027-04-30

Conditions

Small Cell Lung Cancer

Interventions

DRUG

No Results Yet

NCT06087640 | RECRUITING | PHASE3

35800 Participants

A Clinical Study to Evaluate the Efficacy, Safety and Immunogenicity of an Adjuvanted Influenza Vaccine Compared to a Non-adjuvanted Influenza Vaccine in Adults ≥65 Years of Age

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-10-23

Completion: 2026-11-30

Conditions

Influenza, Human

Interventions

BIOLOGICAL

No Results Yet

NCT06077500 | ACTIVE_NOT_RECRUITING | PHASE1

46 Participants

DAREONᵀᴹ-8: A Study to Test How Well Different Doses of BI 764532 in Addition to Standard of Care Are Tolerated by People With Advanced Small Cell Lung Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2024-02-14

Completion: 2025-12-01

Conditions

Small Cell Lung Carcinoma (SCLC)

Interventions

DRUG

No Results Yet

NCT06074588 | RECRUITING | PHASE3

556 Participants

Sacituzumab Tirumotecan (MK-2870) Versus Chemotherapy in Previously Treated Advanced or Metastatic Nonsquamous Non-small Cell Lung Cancer (NSCLC) With EGFR Mutations or Other Genomic Alterations (MK-2870-004)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-11-12

Completion: 2027-05-10

Conditions

Non-small Cell Lung Cancer (NSCLC)

Interventions

BIOLOGICAL DRUG

No Results Yet

NCT06073821 | ACTIVE_NOT_RECRUITING | PHASE3

652 Participants

Study of Sonrotoclax (BGB-11417) Plus Zanubrutinib (BGB-3111) Compared With Venetoclax Plus Obinutuzumab in Participants With Chronic Lymphocytic Leukemia (CLL)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-11-11

Completion: 2032-02-29

Conditions

CLL

Interventions

DRUG

No Results Yet

NCT06067347 | RECRUITING

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2023-09-08

Completion: 2025-10-20

Conditions

Patient Care Team Psychological Well-Being Occupational Burnout

Interventions

BEHAVIORAL

No Results Yet