Clinical Trials

NCT04949542 | COMPLETED | NA
60 Participants

Bolster: Caregiver App to Reduce Duration of Untreated Psychosis

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2023-08-11
Completion: 2024-10-04
Conditions
Caregiver to a Young Adult With Early Psychosis
Interventions
BEHAVIORAL
NCT04938817 | RECRUITING | PHASE1/PHASE2
110 Participants

Safety and Efficacy Study of Investigational Agents as Monotherapy or in Combination With Pembrolizumab (MK-3475) for the Treatment of Extensive-Stage Small Cell Lung Cancer (ES-SCLC) in Need of Second-Line Therapy (MK-3475-B98/KEYNOTE-B98)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-08-19
Completion: 2026-05-20
Conditions
Small Cell Lung Carcinoma
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT04925453 | COMPLETED | NA
56 Participants

tDCS and Cognitive Training in Active Duty Service Members With Mild TBI: A Pilot Study

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-01-19
Completion: 2025-06-30
Conditions
Brain Concussion Brain Trauma Attention Concentration Difficulty Brain Injuries Brain Injuries, Traumatic Neurocognitive Dysfunction Attention Impaired Memory Impairment Mild Traumatic Brain Injury Mild Cognitive Impairment
Interventions
COMBINATION_PRODUCT
No Results Yet
NCT04924088 | ACTIVE_NOT_RECRUITING | NA
85 Participants

Medical-legal Partnerships to Prevent Evictions and Homelessness Among Veterans

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2022-02-01
Completion: 2026-03-01
Conditions
Homelessness Mental Health
Interventions
BEHAVIORAL
No Results Yet
NCT04924075 | RECRUITING | PHASE2
322 Participants

Belzutifan/MK-6482 for the Treatment of Advanced Pheochromocytoma/Paraganglioma (PPGL), Pancreatic Neuroendocrine Tumor (pNET), Von Hippel-Lindau (VHL) Disease-Associated Tumors, Advanced Gastrointestinal Stromal Tumor (wt GIST), or Solid Tumors With HIF-2α Related Genetic Alterations (MK-6482-015)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-08-12
Completion: 2029-06-04
Conditions
Pheochromocytoma/Paraganglioma Pancreatic Neuroendocrine Tumor Von Hippel-Lindau Disease Advanced Gastrointestinal Stromal Tumor HIF-2α Mutated Cancers
Interventions
DRUG
No Results Yet
NCT04923178 | RECRUITING
1100 Participants

A Multi-Center Natural History of Urothelial Cancer and Rare Genitourinary Tract Malignancies

Study Type: OBSERVATIONAL
Last Updated: 2025-11-12
Start Date: 2022-10-24
Completion: 2041-12-01
Conditions
Urothelial Cancer Bladder Cancer Genitourinary Cancer Urogenital Neoplasms Urogenital Cancer
No Results Yet
NCT04922307 | ACTIVE_NOT_RECRUITING | NA
240 Participants

Reduction of Allogenic Blood Transfusion in Locally Advanced Kidney Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-07-23
Completion: 2025-02-12
Conditions
Kidney Cancer
Interventions
PROCEDURE
No Results Yet
NCT04910269 | RECRUITING | PHASE3
820 Participants

Outpatient Treatment With Anti-Coronavirus Immunoglobulin

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-08-06
Completion: 2026-08-01
Conditions
COVID SARS-CoV2 Infection Covid19
Interventions
BIOLOGICAL OTHER
No Results Yet
NCT04906434 | RECRUITING | PHASE1
200 Participants

A Study to Assess the Safety, Tolerability, and Pharmacokinetics of ABSK-011 in Patients With Advanced Solid Tumor

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2020-02-26
Completion: 2027-12-31
Conditions
Advanced Liver Cancer
Interventions
DRUG
No Results Yet
NCT04874519 | COMPLETED
12 Participants

Registry to Collect Health Information Related to Fibrolamellar Cancer

Study Type: OBSERVATIONAL
Last Updated: 2025-11-12
Start Date: 2021-11-24
Completion: 2025-11-10
Conditions
Fibrolamellar Cancer FLC Liver Cancer
Interventions
BEHAVIORAL
No Results Yet
NCT04867837 | RECRUITING | PHASE3
260 Participants

Study of OCTAPLEX in Patients With Acute Major Bleeding on DOAC Therapy With Factor Xa Inhibitor

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-09-01
Completion: 2026-12-31
Conditions
Acute Major Bleeding
Interventions
DRUG
No Results Yet
NCT04851288 | ACTIVE_NOT_RECRUITING | PHASE2
112 Participants

Mitochondrial-targeted Antioxidant Supplementation for Improving Age-related Vascular Dysfunction in Humans

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-04-02
Completion: 2025-12-31
Conditions
Aging
Interventions
DIETARY_SUPPLEMENT
No Results Yet
NCT04840394 | COMPLETED | PHASE1
1 Participants

Clinical Study of BDB018: Monotherapy and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-06-22
Completion: 2024-03-31
Conditions
Tumor, Solid
Interventions
DRUG
No Results Yet
NCT04819373 | COMPLETED | PHASE2
1 Participants

BDB001-201: A Clinical Study of BDB001 in Patients With PD-(L)1 Refractory Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-08-30
Completion: 2023-04-01
Conditions
Tumor, Solid
Interventions
DRUG
No Results Yet
NCT04808427 | RECRUITING | NA
21 Participants

Pilot Study to Investigate Magnetic Resonance (MR) Image Guided Focal Therapy in Prostate Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2023-11-20
Completion: 2027-05-01
Conditions
Prostate Cancer
Interventions
DEVICE
No Results Yet
NCT04801420 | COMPLETED | PHASE2
625 Participants

Phase 2 Study Of VLA15, A Vaccine Candidate Against Lyme Borreliosis, In A Healthy Pediatric And Adult Study Population

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-03-08
Completion: 2022-03-25
Conditions
Lyme Borreliosis
Interventions
BIOLOGICAL
NCT04798274 | RECRUITING | NA
106 Participants

Role of GABAergic Transmission in Auditory Processing in Autism Spectrum Disorder

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-06-15
Completion: 2027-06-30
Conditions
Autism Spectrum Disorder
Interventions
DEVICE
No Results Yet
NCT04794699 | RECRUITING | PHASE1
180 Participants

Study of IDE397 in Participants With Solid Tumors Harboring MTAP Deletion

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-04-14
Completion: 2026-12-31
Conditions
Solid Tumor
Interventions
DRUG
No Results Yet
NCT04792697 | RECRUITING | NA
100 Participants

Experimental Manipulation of Sleep and Circadian Rhythms and the Role Played on Reward Function in Teens

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-05-01
Completion: 2026-03-31
Conditions
Delayed Sleep Phase Syndrome
Interventions
OTHER BEHAVIORAL
No Results Yet
NCT04784715 | ACTIVE_NOT_RECRUITING | PHASE3
1157 Participants

Trastuzumab Deruxtecan (T-DXd) With or Without Pertuzumab Versus Taxane, Trastuzumab and Pertuzumab in HER2-positive Metastatic Breast Cancer (DESTINY-Breast09)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-04-26
Completion: 2026-07-06
Conditions
Breast Cancer; HER2-positive; Metastatic
Interventions
DRUG
No Results Yet
NCT04779177 | COMPLETED | PHASE1
26 Participants

Safety, Tolerability, and Pharmacokinetics of Lumateperone in Pediatric Patients With Schizophrenia or Schizoaffective Disorder

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-03-12
Completion: 2022-07-30
Conditions
Schizophrenia Pediatric
Interventions
DRUG
NCT04777357 | RECRUITING | PHASE3
380 Participants

A Study to Assess Change in Disease Activity and Adverse Events (AEs) With Cariprazine in the Treatment of Depressive Episodes in Pediatric Participants Participants (10 to 17 Years of Age) With Bipolar I Disorder.

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-04-28
Completion: 2027-03-31
Conditions
Depression Bipolar I Disorder
Interventions
DRUG
No Results Yet
NCT04771130 | RECRUITING | PHASE1/PHASE2
260 Participants

A Study of BGB-11417 in Participants With Myeloid Malignancies

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-05-24
Completion: 2028-02-08
Conditions
Acute Myeloid Leukemia Myelodysplastic Syndromes Myelodysplastic/Myeloproliferative Neoplasm
Interventions
DRUG
No Results Yet
NCT04752722 | RECRUITING | PHASE1/PHASE2
350 Participants

LEGEND Study: EG-70 in NMIBC Patients BCG-Unresponsive and High-Risk NMIBC Incompletely Treated With BCG or BCG-Naïve

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-04-22
Completion: 2026-06-30
Conditions
Superficial Bladder Cancer Non-muscle Invasive Bladder Cancer With Carcinoma in Situ
Interventions
DRUG
No Results Yet
NCT04743141 | RECRUITING | PHASE3
600 Participants

Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-04-28
Completion: 2030-07-31
Conditions
Acute Treatment of Migraine
Interventions
DRUG
No Results Yet
NCT04671667 | RECRUITING | PHASE2
188 Participants

Testing What Happens When an Immunotherapy Drug (Pembrolizumab) is Given by Itself Compared to the Usual Treatment of Chemotherapy With Radiation After Surgery for Recurrent Head and Neck Squamous Cell Carcinoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-04-27
Completion: 2029-06-30
Conditions
Recurrent Head and Neck Squamous Cell Carcinoma Recurrent Hypopharyngeal Squamous Cell Carcinoma Recurrent Laryngeal Squamous Cell Carcinoma Recurrent Oral Cavity Squamous Cell Carcinoma Recurrent Oropharyngeal Squamous Cell Carcinoma
Interventions
DRUG PROCEDURE RADIATION BIOLOGICAL
No Results Yet
NCT04657146 | SUSPENDED
40 Participants

Longitudinal Assessment of Marrow and Blood in Patients With Glioblastoma

Study Type: OBSERVATIONAL
Last Updated: 2025-11-12
Start Date: 2024-02-05
Completion: 2027-11-01
Conditions
Glioblastoma
Interventions
OTHER
No Results Yet
NCT04649242 | RECRUITING | PHASE3
2100 Participants

Randomized Study in Children and Adolescents With Migraine: Acute Treatment

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-01-15
Completion: 2029-01-09
Conditions
Pediatric Migraine
Interventions
DRUG
No Results Yet
NCT04647487 | COMPLETED | PHASE1
87 Participants

A Study of LY3484356 in Women With Breast Cancer Before Having Surgery

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-04-21
Completion: 2022-11-11
Conditions
Breast Cancer
Interventions
DRUG
NCT04628767 | RECRUITING | PHASE2/PHASE3
249 Participants

Testing the Addition of MEDI4736 (Durvalumab) to Chemotherapy Before Surgery for Patients With High-Grade Upper Urinary Tract Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-11-12
Completion: 2027-09-30
Conditions
Renal Pelvis and Ureter Urothelial Carcinoma
Interventions
PROCEDURE DRUG BIOLOGICAL
No Results Yet
NCT04628494 | ACTIVE_NOT_RECRUITING | PHASE3
484 Participants

A Phase 3 Trial of Epcoritamab vs Investigator's Choice Chemotherapy in Relapsed/Refractory (R/R) Diffuse Large B-cell Lymphoma (DLBCL)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-01-13
Completion: 2025-10-13
Conditions
Diffuse Large B-cell Lymphoma
Interventions
BIOLOGICAL DRUG
No Results Yet
NCT04622332 | COMPLETED | PHASE1
45 Participants

A Pilot Study to Assess Safety and Efficacy of SIR1-365 in Patients With Severe COVID-19

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2020-12-18
Completion: 2021-11-27
Conditions
Corona Virus Infection
Interventions
DRUG
NCT04614103 | RECRUITING | PHASE2
170 Participants

Autologous LN-145 in Patients With Metastatic Non-Small-Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-05-07
Completion: 2030-12-31
Conditions
Metastatic Non Small Cell Lung Cancer
Interventions
BIOLOGICAL
No Results Yet
NCT04613596 | RECRUITING | PHASE2/PHASE3
806 Participants

Phase 2 Trial of Adagrasib Monotherapy and in Combination With Pembrolizumab and a Phase 3 Trial of Adagrasib in Combination in Patients With a KRAS G12C Mutation KRYSTAL-7

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2020-12-02
Completion: 2028-10-31
Conditions
Advanced Non-Small Cell Lung Cancer Metastatic Non-Small Cell Lung Cancer
Interventions
DRUG
No Results Yet
NCT04606095 | RECRUITING | NA
150 Participants

Explosive Synchronization of Brain Network Activity in Chronic Pain

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2020-11-13
Completion: 2026-02-20
Conditions
Fibromyalgia Healthy Volunteers
Interventions
DIAGNOSTIC_TEST DEVICE
No Results Yet
NCT04579224 | RECRUITING | PHASE3
184 Participants

Comparing the New Anti-cancer Drug Eribulin With Chemotherapy Against the Usual Chemotherapy Alone in Metastatic Urothelial Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-06-28
Completion: 2030-08-15
Conditions
Metastatic Bladder Urothelial Carcinoma Metastatic Urothelial Carcinoma Refractory Bladder Urothelial Carcinoma Refractory Urothelial Carcinoma Stage IV Bladder Cancer AJCC v8
Interventions
PROCEDURE DRUG BIOLOGICAL
No Results Yet
NCT04561518 | RECRUITING
1500 Participants

ConTTRibute: A Global Observational Study of Patients With Transthyretin (TTR)-Mediated Amyloidosis (ATTR Amyloidosis)

Study Type: OBSERVATIONAL
Last Updated: 2025-11-12
Start Date: 2020-11-23
Completion: 2030-09-01
Conditions
Transthyretin-Mediated Amyloidosis ATTR Amyloidosis
No Results Yet
NCT04551430 | ACTIVE_NOT_RECRUITING | PHASE2
105 Participants

Cabozantinib Combined With PD-1 and CTLA-4 Inhibition in Metastatic Soft Tissue Sarcoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2021-01-05
Completion: 2027-02-01
Conditions
Metastatic Soft-tissue Sarcoma
Interventions
DRUG
No Results Yet
NCT04551170 | ACTIVE_NOT_RECRUITING | PHASE2
34 Participants

Theophylline Treatment for Pseudohypoparathyroidism - Children 2-12 Years Old

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2020-07-13
Completion: 2026-12-31
Conditions
Pseudohypoparathyroidism Albright Hereditary Osteodystrophy Pseudohypoparathyroidism Type 1a
Interventions
DRUG
No Results Yet
NCT04543591 | ACTIVE_NOT_RECRUITING | PHASE3
148 Participants

Ravulizumab in Thrombotic Microangiopathy After Hematopoietic Stem Cell Transplant

Study Type: INTERVENTIONAL
Last Updated: 2025-11-12
Start Date: 2020-12-10
Completion: 2025-09-19
Conditions
Thrombotic Microangiopathy
Interventions
BIOLOGICAL OTHER
No Results Yet
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