Clinical Trials

NCT04001829 | ACTIVE_NOT_RECRUITING | PHASE2

249 Participants

Taxane and Taxane-Induced Peripheral Neuropathy in African American Patients With Stage I-III Breast Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2019-08-09

Completion: 2023-09-19

Conditions

Anatomic Stage I Breast Cancer AJCC v8 Anatomic Stage IA Breast Cancer AJCC v8 Anatomic Stage IB Breast Cancer AJCC v8 Anatomic Stage II Breast Cancer AJCC v8 Anatomic Stage IIA Breast Cancer AJCC v8 Anatomic Stage IIB Breast Cancer AJCC v8 Anatomic Stage III Breast Cancer AJCC v8 Anatomic Stage IIIA Breast Cancer AJCC v8 Anatomic Stage IIIB Breast Cancer AJCC v8 Anatomic Stage IIIC Breast Cancer AJCC v8 Invasive Breast Carcinoma Prognostic Stage I Breast Cancer AJCC v8 Prognostic Stage IA Breast Cancer AJCC v8 Prognostic Stage IB Breast Cancer AJCC v8 Prognostic Stage II Breast Cancer AJCC v8 Prognostic Stage IIA Breast Cancer AJCC v8 Prognostic Stage IIB Breast Cancer AJCC v8 Prognostic Stage III Breast Cancer AJCC v8 Prognostic Stage IIIA Breast Cancer AJCC v8 Prognostic Stage IIIB Breast Cancer AJCC v8 Prognostic Stage IIIC Breast Cancer AJCC v8

Interventions

DRUG OTHER

Results Available

NCT03987386 | ACTIVE_NOT_RECRUITING | PHASE3

186 Participants

Conventional or Hypofractionated Radiation Therapy in Treating Patients With Prostate Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2019-05-30

Completion: 2027-11-01

Conditions

Stage I Prostate Cancer AJCC v8 Stage II Prostate Cancer AJCC v8 Stage III Prostate Cancer AJCC v8 Stage IVA Prostate Cancer AJCC v8

Interventions

RADIATION OTHER

No Results Yet

NCT03986021 | RECRUITING

400 Participants

Reproductive Axis Maturation in the Early Post-Menarchal Years

Study Type: OBSERVATIONAL

Last Updated: 2025-11-12

Start Date: 2019-12-19

Completion: 2029-07-01

Conditions

Reproductive Physiological Processes Pediatrics Adolescent Health Adolescent Development

No Results Yet

NCT03979508 | TERMINATED | PHASE2

26 Participants

Abemaciclib in Treating Patients With Surgically Resectable, Chemotherapy Resistant, Triple Negative Breast Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2020-01-10

Completion: 2024-12-26

Conditions

Anatomic Stage I Breast Cancer AJCC v8 Anatomic Stage II Breast Cancer AJCC v8 Anatomic Stage III Breast Cancer AJCC v8 Breast Ductal Carcinoma In Situ Breast Fibrocystic Change Breast Lobular Carcinoma In Situ Invasive Breast Carcinoma Prognostic Stage I Breast Cancer AJCC v8 Prognostic Stage IA Breast Cancer AJCC v8 Prognostic Stage IB Breast Cancer AJCC v8 Prognostic Stage II Breast Cancer AJCC v8 Prognostic Stage IIA Breast Cancer AJCC v8 Prognostic Stage IIB Breast Cancer AJCC v8 Prognostic Stage III Breast Cancer AJCC v8 Prognostic Stage IIIA Breast Cancer AJCC v8 Prognostic Stage IIIB Breast Cancer AJCC v8 Prognostic Stage IIIC Breast Cancer AJCC v8 Triple-Negative Breast Carcinoma

Interventions

DRUG PROCEDURE

No Results Yet

NCT03970603 | COMPLETED | NA

40 Participants

Syndesmosis Ankle Study

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2019-10-15

Completion: 2023-10-26

Conditions

Syndesmotic Disruption Weight-bearing Status

Interventions

OTHER

No Results Yet

NCT03950817 | COMPLETED | PHASE4

80 Participants

Nebulized Sub-dissociative Dose Ketamine at Three Different Dosing Regimens for Treating Acute Pain in the Pediatric ED

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2019-05-13

Completion: 2024-09-24

Conditions

Pain

Interventions

DRUG

Results Available

NCT03942770 | ACTIVE_NOT_RECRUITING | NA

91 Participants

Remote Alcohol Monitoring to Facilitate Abstinence From Alcohol: Exp 2

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2019-07-15

Completion: 2025-09-01

Conditions

Alcohol Use Disorder

Interventions

BEHAVIORAL

No Results Yet

NCT03916419 | COMPLETED | PHASE2

26 Participants

Magnetic Resonance-Guided Hypofractionated Adaptive Radiation Therapy With Concurrent Chemotherapy and Consolidation Durvalumab for Inoperable Stage IIB, IIIA, and Select IIIB and IIIC Non-small Cell Lung Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2019-06-20

Completion: 2025-09-28

Conditions

Stage IIB Non-Small Cell Lung Cancer Stage IIIA Non-small Cell Lung Cancer Stage IIIB Non-small Cell Lung Cancer Stage IIIC Non-Small Cell Lung Cancer

Interventions

DEVICE RADIATION DRUG BIOLOGICAL

No Results Yet

NCT03911557 | COMPLETED | PHASE2

14 Participants

Durvalumab and Tremelimumab Combination in Somatically Hypermutated Recurrent Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2019-06-08

Completion: 2025-10-10

Conditions

Tumor, Solid

Interventions

DRUG

No Results Yet

NCT03907488 | ACTIVE_NOT_RECRUITING | PHASE3

994 Participants

Immunotherapy (Nivolumab or Brentuximab Vedotin) Plus Combination Chemotherapy in Treating Patients With Newly Diagnosed Stage III-IV Classic Hodgkin Lymphoma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2019-08-29

Completion: 2024-03-31

Conditions

Ann Arbor Stage III Hodgkin Lymphoma Ann Arbor Stage III Lymphocyte-Depleted Classic Hodgkin Lymphoma Ann Arbor Stage III Mixed Cellularity Classic Hodgkin Lymphoma Ann Arbor Stage III Nodular Sclerosis Classic Hodgkin Lymphoma Ann Arbor Stage IV Hodgkin Lymphoma Ann Arbor Stage IV Lymphocyte-Depleted Classic Hodgkin Lymphoma Ann Arbor Stage IV Mixed Cellularity Classic Hodgkin Lymphoma Ann Arbor Stage IV Nodular Sclerosis Classic Hodgkin Lymphoma Classic Hodgkin Lymphoma Lymphocyte-Rich Classic Hodgkin Lymphoma

Interventions

PROCEDURE DRUG BIOLOGICAL OTHER RADIATION

Results Available

NCT03895645 | ENROLLING_BY_INVITATION

1000 Participants

Connors Protocol for the Management and Use of Stored Human Specimens (Stored Human Specimens)

Study Type: OBSERVATIONAL

Last Updated: 2025-11-12

Start Date: 2025-11-17

Completion: 2029-12-31

Conditions

Healthy Volunteer Samples

No Results Yet

NCT03893318 | TERMINATED | PHASE4

15 Participants

IV Lidocaine in Pediatric AIS

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2019-07-30

Completion: 2024-12-31

Conditions

Systemic Lidocaine Improves Pain Control After Surgery by Attenuating the Systemic Inflammatory Response to Surgery

Interventions

DRUG

Results Available

NCT03883126 | ACTIVE_NOT_RECRUITING | NA

211 Participants

Remote Alcohol Monitoring to Facilitate Abstinence From Alcohol: Exp 1

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2020-06-16

Completion: 2025-09-01

Conditions

Alcohol Use Disorder

Interventions

BEHAVIORAL

No Results Yet

NCT03866668 | RECRUITING | PHASE2

25 Participants

A Study of Esomeprazole in Children With Autism

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2019-05-29

Completion: 2028-12-31

Conditions

Autism Autism Spectrum Disorder

Interventions

DRUG

No Results Yet

NCT03846830 | COMPLETED | NA

24 Participants

Incremental Velocity Error as a New Treatment in Vestibular Rehabilitation

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2021-10-11

Completion: 2025-04-01

Conditions

Mild Traumatic Brain Injury Vestibular Neuropathy

Interventions

DEVICE BEHAVIORAL

No Results Yet

NCT03838627 | COMPLETED

34 Participants

Feasibility and Agreement of Remote Evaluation of Resting Heart Rate and Heart Rate Variability in Survivors of Hodgkin Lymphoma Treated With Chest Radiation (PILOT STUDY-SURVIVOR)

Study Type: OBSERVATIONAL

Last Updated: 2025-11-12

Start Date: 2019-02-05

Completion: 2021-01-19

Conditions

Hodgkin Disease

No Results Yet

NCT03812653 | RECRUITING | NA

3062 Participants

Sleep for Stroke Management and Recovery Trial

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2019-05-09

Completion: 2026-11-30

Conditions

Ischemic Stroke Sleep Apnea Sleep Apnea, Obstructive Stroke CPAP Telemedicine Home Sleep Apnea Test Randomized Clinical Trial Multicenter Trial

Interventions

DEVICE

No Results Yet

NCT03811015 | SUSPENDED | PHASE3

636 Participants

Testing Immunotherapy Versus Observation in Patients With HPV Throat Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2019-08-16

Completion: 2027-01-01

Conditions

Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8

Interventions

PROCEDURE DRUG OTHER RADIATION BIOLOGICAL

No Results Yet

NCT03805919 | RECRUITING

500 Participants

Men at High Genetic Risk for Prostate Cancer

Study Type: OBSERVATIONAL

Last Updated: 2025-11-12

Start Date: 2019-03-27

Completion: 2029-01-01

Conditions

Prostatic Neoplasms

No Results Yet

NCT03758638 | COMPLETED | PHASE3

620 Participants

Healthy Eating and Active Living Taught at Home (HEALTH) Dissemination & Implementation (D&I)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2019-01-25

Completion: 2024-07-31

Conditions

Obesity

Interventions

BEHAVIORAL

Results Available

NCT03738228 | COMPLETED | PHASE1

40 Participants

Atezolizumab Before and/or With Chemoradiotherapy in Immune System Activation in Patients With Node Positive Stage IB2, II, IIIB, or IVA Cervical Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2019-01-07

Completion: 2022-05-01

Conditions

Cervical Adenocarcinoma Cervical Adenosquamous Carcinoma Cervical Squamous Cell Carcinoma Stage IB2 Cervical Cancer AJCC v8 Stage II Cervical Cancer AJCC v8 Stage IIA Cervical Cancer AJCC v8 Stage IIA1 Cervical Cancer AJCC v8 Stage IIA2 Cervical Cancer AJCC v8 Stage IIB Cervical Cancer AJCC v8 Stage IIIB Cervical Cancer AJCC v8 Stage IVA Cervical Cancer AJCC v8

Interventions

DRUG RADIATION

Results Available

NCT03723564 | RECRUITING | PHASE1

40 Participants

Serial Amnioinfusions as Regenerative Therapy for Pulmonary Hypoplasia

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2018-10-01

Completion: 2026-12-31

Conditions

Renal Failure Congenital Congenital Renal Anomaly Nos Renal Agenesis and Dysgenesis Lower Urinary Tract Obstructive Syndrome

Interventions

DRUG

No Results Yet

NCT03660826 | ACTIVE_NOT_RECRUITING | PHASE2

288 Participants

Testing the Combination of Olaparib and Durvalumab, Cediranib and Durvalumab, Olaparib and Capivasertib, and Cediranib Alone in Recurrent or Refractory Endometrial Cancer Following the Earlier Phase of the Study That Tested Olaparib and Cediranib in Comparison to Cediranib Alone, and Olaparib Alone

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2018-09-27

Completion: 2024-12-06

Conditions

Endometrial Adenocarcinoma Endometrial Mixed Cell Adenocarcinoma Endometrial Serous Adenocarcinoma Endometrial Undifferentiated Carcinoma Endometrioid Adenocarcinoma Stage IV Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8

Interventions

PROCEDURE DRUG BIOLOGICAL

Results Available

NCT03656718 | COMPLETED | PHASE1/PHASE2

139 Participants

A Study of Subcutaneous Nivolumab Monotherapy With or Without Recombinant Human Hyaluronidase PH20 (rHuPH20)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2018-10-29

Completion: 2022-09-07

Conditions

Neoplasms by Site

Interventions

BIOLOGICAL DRUG

Results Available

NCT03599245 | COMPLETED | PHASE3

1055 Participants

This is an Extension Study of the Roche P-trials to Investigate Safety and Effectiveness of Ocrelizumab in Participants With Multiple Sclerosis (MS)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2018-07-12

Completion: 2025-07-17

Conditions

Multiple Sclerosis

Interventions

DRUG

No Results Yet

NCT03595124 | ACTIVE_NOT_RECRUITING | PHASE2

15 Participants

A Study to Compare Treatments for a Type of Kidney Cancer Called TFE/Translocation Renal Cell Carcinoma (tRCC)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2019-01-08

Completion: 2024-09-30

Conditions

Metastatic Renal Cell Carcinoma Stage III Renal Cell Cancer AJCC v8 Stage IV Renal Cell Cancer AJCC v8 TFE3-Rearranged Renal Cell Carcinoma Unresectable Renal Cell Carcinoma

Interventions

DRUG BIOLOGICAL

Results Available

NCT03591510 | ACTIVE_NOT_RECRUITING | PHASE2

22 Participants

A Global Study of Midostaurin in Combination With Chemotherapy to Evaluate Safety, Efficacy and Pharmacokinetics in Newly Diagnosed Pediatric Patients With FLT3 Mutated AML

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2019-03-13

Completion: 2027-05-03

Conditions

FLT3-mutated Acute Myeloid Leukemia

Interventions

DRUG

No Results Yet

NCT03582475 | ACTIVE_NOT_RECRUITING | PHASE1

15 Participants

Pembrolizumab With Combination Chemotherapy in Treating Participants With Locally Advanced or Metastatic Small Cell/Neuroendocrine Cancers of Urothelium or Prostate

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2019-01-11

Completion: 2025-12-01

Conditions

Bladder Small Cell Neuroendocrine Carcinoma Castration-Resistant Prostate Carcinoma Metastatic Bladder Urothelial Carcinoma Metastatic Urethral Urothelial Carcinoma Prostate Carcinoma Metastatic in the Bone Prostate Neuroendocrine Neoplasm Prostate Small Cell Carcinoma Stage III Bladder Cancer American Joint Committee on Cancer ( AJCC) v8 Stage III Prostate Cancer AJCC v8 Stage III Urethral Cancer AJCC v8 Stage IV Bladder Cancer AJCC v8 Stage IV Prostate Cancer AJCC v8 Stage IV Urethral Cancer AJCC v8 Stage IVA Bladder Cancer AJCC v8 Stage IVB Bladder Cancer AJCC v8 Ureter Small Cell Carcinoma Urothelial Carcinoma

Interventions

DRUG BIOLOGICAL

Results Available

NCT03579901 | ACTIVE_NOT_RECRUITING | NA

800 Participants

Study of the Safety and Effectiveness of Motiva Implants®

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2018-04-06

Completion: 2032-08-30

Conditions

Breast Implants

Interventions

DEVICE

No Results Yet

NCT03523442 | ACTIVE_NOT_RECRUITING | PHASE1

19 Participants

A Study of Androgen Receptor (AR) Antagonist Apalutamide in Chinese Participants With Metastatic Castration-Resistant Prostate Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2018-08-31

Completion: 2019-07-09

Conditions

Prostatic Neoplasms

Interventions

DRUG

No Results Yet

NCT03516942 | ACTIVE_NOT_RECRUITING

565 Participants

Financial Burden Assessment in Patients With Stage I-III Colon or Rectal Cancer Undergoing Treatment

Study Type: OBSERVATIONAL

Last Updated: 2025-11-12

Start Date: 2018-06-11

Completion: 2023-12-31

Conditions

Stage I Colon Cancer AJCC v8 Stage I Rectal Cancer AJCC v8 Stage II Colon Cancer AJCC v8 Stage II Rectal Cancer AJCC v8 Stage IIA Colon Cancer AJCC v8 Stage IIA Rectal Cancer AJCC v8 Stage IIB Colon Cancer AJCC v8 Stage IIB Rectal Cancer AJCC v8 Stage IIC Colon Cancer AJCC v8 Stage IIC Rectal Cancer AJCC v8 Stage III Colon Cancer AJCC v8 Stage III Rectal Cancer AJCC v8 Stage IIIA Colon Cancer AJCC v8 Stage IIIA Rectal Cancer AJCC v8 Stage IIIB Colon Cancer AJCC v8 Stage IIIB Rectal Cancer AJCC v8 Stage IIIC Colon Cancer AJCC v8 Stage IIIC Rectal Cancer AJCC v8

Interventions

OTHER

Results Available

NCT03498612 | TERMINATED | PHASE2

9 Participants

Pembrolizumab in Untreated B-Cell Non-Hodgkin Lymphoproliferative Diseases

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2018-07-09

Completion: 2021-06-09

Conditions

Follicular Lymphoma Indolent B-Cell Non-Hodgkin Lymphoma Marginal Zone Lymphoma

Interventions

OTHER BIOLOGICAL

Results Available

NCT03492177 | ACTIVE_NOT_RECRUITING | PHASE2

63 Participants

A Clinical Study of to Confirm the Doses of Selexipag in Children With Pulmonary Arterial Hypertension

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2018-07-23

Completion: 2022-03-28

Conditions

Pulmonary Arterial Hypertension

Interventions

DRUG

Results Available

NCT03486301 | COMPLETED | PHASE1

87 Participants

BDB001-101: Clinical Study of BDB001 as a Mono-therapy or in Combination With Pembrolizumab

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2018-02-15

Completion: 2024-03-31

Conditions

Tumor, Solid

Interventions

DRUG

No Results Yet

NCT03482297 | RECRUITING | PHASE1/PHASE2

31 Participants

Automated Abdominal Binder for Orthostatic Hypotension

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2018-03-01

Completion: 2026-07-01

Conditions

Orthostatic Hypotension Autonomic Failure Pure Autonomic Failure Multiple System Atrophy

Interventions

DEVICE DRUG

No Results Yet

NCT03473743 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

125 Participants

A Study of Erdafitinib in Participants With Metastatic or Locally Advanced Urothelial Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2018-04-05

Completion: 2022-09-30

Conditions

Urothelial Carcinoma

Interventions

DRUG

Results Available

NCT03466411 | ACTIVE_NOT_RECRUITING | PHASE2/PHASE3

1409 Participants

A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2018-04-13

Completion: 2023-10-20

Conditions

Crohn's Disease

Interventions

DRUG

Results Available

NCT03431350 | ACTIVE_NOT_RECRUITING | PHASE2

136 Participants

A Study of Niraparib Combination Therapies for the Treatment of Metastatic Castration-Resistant Prostate Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2018-03-02

Completion: 2021-08-31

Conditions

Prostatic Neoplasms, Castration-Resistant

Interventions

DRUG

Results Available

NCT03431064 | RECRUITING

48 Participants

Lung Recruitment Maneuver as a Potential Predictor of Fluid Responsiveness in Mechanically Ventilated Pediatric Patients

Study Type: OBSERVATIONAL

Last Updated: 2025-11-12

Start Date: 2018-06-21

Completion: 2027-12-31

Conditions

Anesthesia Intravenous Fluid Blood Pressure

Interventions

OTHER

No Results Yet

NCT03375320 | ACTIVE_NOT_RECRUITING | PHASE3

298 Participants

Testing Cabozantinib in Patients With Advanced Pancreatic Neuroendocrine and Carcinoid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-11-12

Start Date: 2018-10-26

Completion: 2023-08-23

Conditions

Lung Neuroendocrine Tumor Lung Neuroendocrine Tumor G2 Metastatic Digestive System Neuroendocrine Neoplasm Functioning Pancreatic Neuroendocrine Tumor Intermediate Grade Lung Neuroendocrine Neoplasm Locally Advanced Digestive System Neuroendocrine Neoplasm Locally Advanced Digestive System Neuroendocrine Tumor G1 Locally Advanced Lung Neuroendocrine Neoplasm Locally Advanced Pancreatic Neuroendocrine Tumor Locally Advanced Unresectable Digestive System Neuroendocrine Neoplasm Low Grade Lung Neuroendocrine Neoplasm Metastatic Digestive System Neuroendocrine Tumor G1 Metastatic Lung Neuroendocrine Neoplasm Metastatic Lung Neuroendocrine Tumor Metastatic Pancreatic Neuroendocrine Neoplasm Metastatic Pancreatic Neuroendocrine Tumor Metastatic Thymus Neuroendocrine Neoplasm Neuroendocrine Neoplasm Neuroendocrine Tumor Neuroendocrine Tumor G2 Non-Functioning Pancreatic Neuroendocrine Tumor Pancreatic Serotonin-Producing Neuroendocrine Tumor Thymus Neuroendocrine Tumor Unresectable Digestive System Neuroendocrine Neoplasm Unresectable Digestive System Neuroendocrine Tumor G1 Unresectable Lung Neuroendocrine Neoplasm Unresectable Pancreatic Neuroendocrine Neoplasm Unresectable Thymus Neuroendocrine Neoplasm

Interventions

PROCEDURE DRUG OTHER

Results Available