Clinical Trials
62
Participants
Tazemetostat in Treating Patients With Recurrent Ovarian or Endometrial Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2019-05-01
Completion:
2023-07-28
Conditions
Recurrent Endometrial Endometrioid Adenocarcinoma
Recurrent Malignant Uterine Corpus Neoplasm
Recurrent Ovarian Carcinoma
Recurrent Ovarian Clear Cell Adenocarcinoma
Recurrent Ovarian Endometrioid Adenocarcinoma
Interventions
PROCEDURE
DRUG
9
Participants
Testing the Addition of Radiation Therapy to Immunotherapy for Merkel Cell Carcinoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2018-06-12
Completion:
2022-06-07
Conditions
Advanced Merkel Cell Carcinoma
Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8
Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8
Metastatic Merkel Cell Carcinoma
Pathologic Stage III Cutaneous Merkel Cell Carcinoma AJCC v8
Pathologic Stage IIIA Cutaneous Merkel Cell Carcinoma AJCC v8
Pathologic Stage IIIB Cutaneous Merkel Cell Carcinoma AJCC v8
Pathologic Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8
Interventions
BIOLOGICAL
RADIATION
68
Participants
Developing a Dyadic Intervention for Sexually Transmitted Infection (STI)/HIV Prevention in Youth
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2018-01-15
Completion:
2021-10-01
Conditions
Exposure to Sexually Transmissible Disorder (Event)
Interventions
BEHAVIORAL
202
Participants
Simplified Patient Care Strategy in Decreasing Early Death in Patients With Acute Promyelocytic Leukemia
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2017-09-26
Completion:
2023-04-27
Conditions
Acute Promyelocytic Leukemia With PML-RARA
t(15;17)
Interventions
OTHER
1376
Participants
Targeted Therapy Directed by Genetic Testing in Treating Pediatric Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphomas, or Histiocytic Disorders (The Pediatric MATCH Screening Trial)
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2017-07-31
Completion:
2025-03-31
Conditions
Advanced Malignant Solid Neoplasm
Ann Arbor Stage III Non-Hodgkin Lymphoma
Ann Arbor Stage IV Non-Hodgkin Lymphoma
Histiocytic Sarcoma
Juvenile Xanthogranuloma
Langerhans Cell Histiocytosis
Malignant Glioma
Recurrent Childhood Rhabdomyosarcoma
Recurrent Ependymoma
Recurrent Ewing Sarcoma
Recurrent Glioma
Recurrent Hepatoblastoma
Recurrent Langerhans Cell Histiocytosis
Recurrent Malignant Germ Cell Tumor
Recurrent Malignant Solid Neoplasm
Recurrent Medulloblastoma
Recurrent Neuroblastoma
Recurrent Non-Hodgkin Lymphoma
Recurrent Osteosarcoma
Recurrent Peripheral Primitive Neuroectodermal Tumor
Recurrent Primary Central Nervous System Neoplasm
Recurrent Rhabdoid Tumor
Recurrent Soft Tissue Sarcoma
Refractory Ewing Sarcoma
Refractory Glioma
Refractory Hepatoblastoma
Refractory Langerhans Cell Histiocytosis
Refractory Malignant Germ Cell Tumor
Refractory Malignant Solid Neoplasm
Refractory Medulloblastoma
Refractory Neuroblastoma
Refractory Non-Hodgkin Lymphoma
Refractory Osteosarcoma
Refractory Peripheral Primitive Neuroectodermal Tumor
Refractory Primary Central Nervous System Neoplasm
Refractory Rhabdoid Tumor
Refractory Rhabdomyosarcoma
Rhabdoid Tumor
Stage III Osteosarcoma AJCC v7
Stage III Soft Tissue Sarcoma AJCC v7
Stage IV Osteosarcoma AJCC v7
Stage IV Soft Tissue Sarcoma AJCC v7
Stage IVA Osteosarcoma AJCC v7
Stage IVB Osteosarcoma AJCC v7
Wilms Tumor
Interventions
PROCEDURE
DRUG
OTHER
No Results Yet
36
Participants
Tesamorelin to Improve Functional Outcomes After Peripheral Nerve Injury
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2018-06-01
Completion:
2027-12-31
Conditions
Peripheral Nerve Injuries
Interventions
DRUG
No Results Yet
48
Participants
Osimertinib and Gefitinib in EGFR Inhibitor naรฏve Advanced EGFR Mutant Lung Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2017-05-09
Completion:
2026-10-31
Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG
No Results Yet
8000
Participants
MILDยฎ Percutaneous Image-Guided Lumbar Decompression: A Medicare Claims Study
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-12
Start Date:
2017-03-10
Completion:
2026-12-31
Conditions
Lumbar Spinal Stenosis
Interventions
DEVICE
No Results Yet
85
Participants
Clinical and Physiological Studies of Tremor Syndromes
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-12
Start Date:
2017-05-05
Completion:
2022-03-23
Conditions
Parkinson Disease
Dystonia
Essential Tremor
No Results Yet
17
Participants
Trial of Nivolumab as a Novel Neoadjuvant Pre-Surgical Therapy for Locally Advanced Oral Cavity Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2017-05-30
Completion:
2021-11-15
Conditions
Oral Cavity SCC
Interventions
DRUG
43
Participants
An Extension Protocol for Subjects Who Successfully Completed PRO140_CD02 or PRO140_CD02_Open Label Study
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2016-11-03
Completion:
2022-06-30
Conditions
Human Immunodeficiency Virus (HIV)
Interventions
DRUG
43
Participants
Continuous Non-Invasive SpHb and PVI Monitoring on Intra-Operative and Post-Surgical Clinical Outcomes
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2016-12-15
Completion:
2018-08-31
Conditions
Surgery
Interventions
DEVICE
165
Participants
A Study to Assess Whether Macitentan Delays Disease Progression in Children With Pulmonary Arterial Hypertension (PAH)
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2017-10-24
Completion:
2024-08-28
Conditions
Pulmonary Arterial Hypertension
Interventions
DRUG
OTHER
5
Participants
Deep Brain Stimulation Surgery for Focal Hand Dystonia
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2018-01-17
Completion:
2029-02-02
Conditions
Dystonia
Focal Dystonia
Musician's Dystonia
Interventions
PROCEDURE
DEVICE
No Results Yet
26
Participants
Trial of CUDC-907 in Children and Young Adults With Relapsed or Refractory Solid Tumors, CNS Tumors, or Lymphoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2016-10-31
Completion:
2026-01-31
Conditions
Lymphoma
Neuroblastoma
Brain Tumor
Solid Tumor
Interventions
DRUG
No Results Yet
289
Participants
An Efficacy and Safety Study of Niraparib in Men With Metastatic Castration-Resistant Prostate Cancer and DNA-Repair Anomalies
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2016-08-31
Completion:
2021-01-26
Conditions
Prostatic Neoplasms
Interventions
DRUG
18
Participants
Nivolumab in Combination With Plinabulin in Patients With Metastatic Non-Small Cell Lung Cancer (NSCLC)
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2016-08-29
Completion:
2024-11-24
Conditions
Non-small Cell Lung Cancer Metastatic
Interventions
DRUG
No Results Yet
160
Participants
A Phase II Trial of Intensity-Modulated Proton Therapy for Incompletely Resected Craniopharyngioma and Observation for Craniopharyngioma After Radical Resection
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2016-06-22
Completion:
2026-08-31
Conditions
Craniopharyngioma
Interventions
RADIATION
PROCEDURE
No Results Yet
33
Participants
DNA Vaccine Therapy in Treating Patients With Chronic Hepatitis C Virus Infection
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2016-06-06
Completion:
2020-03-04
Conditions
Chronic Hepatitis
Hepatitis C Infection
Hepatocellular Carcinoma
Interventions
BIOLOGICAL
OTHER
No Results Yet
156
Participants
PROMOTE: Identifying Predictive Markers of Response for Genitourinary Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2016-05-25
Completion:
2027-03-31
Conditions
Prostate Cancer
Advanced Renal Cell Carcinoma
Advanced Urothelial Carcinoma
Genitourinary Cancer
Interventions
OTHER
DEVICE
No Results Yet
58
Participants
Autoimmune Basis for Postural Tachycardia Syndrome
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2016-02-29
Completion:
2026-10-31
Conditions
Postural Orthostatic Tachycardia Syndrome
Postural Tachycardia Syndrome
Tachycardia
Arrhythmias, Cardiac
Autonomic Nervous System Diseases
Orthostatic Intolerance
Cardiovascular Diseases
Primary Dysautonomias
Interventions
DRUG
RADIATION
PROCEDURE
OTHER
No Results Yet
677
Participants
Fluorescent Cholangiography vs White Light for Bile Ducts Identification
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2016-04-30
Completion:
2017-12-31
Conditions
Cholecystitis
Cholelithiasis
Interventions
PROCEDURE
308
Participants
Optimal Treatment for Recurrent Clostridium Difficile
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2015-12-21
Completion:
2024-08-07
Conditions
Clostridium
Difficile
Fidaxomicin
Vancomycin
Interventions
DRUG
150
Participants
Evaluation of Three Pulp Vitality Tests
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-12
Start Date:
2026-01-31
Completion:
2027-12-31
Conditions
Dental Pulp Diseases
Dental Pulp Vitality Testing
Interventions
DEVICE
No Results Yet
0
Participants
Ultrasound vs Veinviewer in Patients With Difficulty IV Access
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2016-08-01
Completion:
2025-05-05
Conditions
Vascular Access Complication
Interventions
DEVICE
No Results Yet
332
Participants
A Molecular Anatomic Imaging Analysis of Tau in Progressive Supranuclear Palsy
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2015-11-30
Completion:
2025-11-30
Conditions
Progressive Supranuclear Palsy
Interventions
DRUG
No Results Yet
215
Participants
A Study to Test the Effect of the Drug Larotrectinib in Adults and Children With NTRK-fusion Positive Solid Tumors
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2015-09-30
Completion:
2025-09-29
Conditions
Solid Tumors Harboring NTRK Fusion
Interventions
DRUG
No Results Yet
10000
Participants
Human Biospecimen Procurement Protocol: Biorepository to Support Translational Research to Identify Disease Mechanism(s)
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-12
Start Date:
2015-09-17
Completion:
2040-06-04
Conditions
Undiagnosed Diseases
Cardiovascular Disease
No Results Yet
340
Participants
Study to Assess MEDI4736 With Either AZD9150 or AZD5069 in Advanced Solid Tumors & Relapsed Metastatic Squamous Cell Carcinoma of Head & Neck
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2015-08-06
Completion:
2020-02-28
Conditions
Advanced Solid Tumors & Metastatic Squamous Cell Carcinoma of the Head and Neck
Interventions
DRUG
268
Participants
Phase I/II Study of the Anti-Programmed Death Ligand-1 Durvalumab Antibody (MEDI4736) in Combination With Olaparib and/or Cediranib for Advanced Solid Tumors and Advanced or Recurrent Ovarian, Triple Negative Breast, Lung, Prostate and Colorectal Can...
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2015-06-29
Completion:
2026-04-01
Conditions
Colorectal Neoplasms
Breast Neoplasms
Interventions
DRUG
No Results Yet
200
Participants
Compassionate Access of the Miltenyi Device for CD34+ Cell Selection
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2015-05-06
Completion:
2027-05-01
Conditions
Blood And Marrow Transplantation
Interventions
BIOLOGICAL
DEVICE
No Results Yet
49331
Participants
Women's Health Initiative Strong and Healthy Study
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2015-04-02
Completion:
2024-12-31
Conditions
Myocardial Infarction
Stroke
Cardiovascular Mortality
Hip Fractures
Falls
Mortality
Venous Thromboembolic Event
Peripheral Artery Disease
Physical Function
Coronary Revascularization
Mobility and Independence
Clinical (Non-hip) Fractures
Sleep
Depressive Symptoms
Interventions
BEHAVIORAL
No Results Yet
100
Participants
Relationship Between Endoscopic Ultrasound Staging and Degree of Stricture in Esophageal Cancer
Study Type:
OBSERVATIONAL
Last Updated:
2025-11-12
Start Date:
2012-04-30
Completion:
2014-04-30
Conditions
Esophageal Cancer
Interventions
PROCEDURE
No Results Yet
239
Participants
An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2015-04-22
Completion:
2022-09-15
Conditions
Urothelial Cancer
Interventions
DRUG
600
Participants
A Phase II/III Trial of Nivolumab, Ipilimumab, and GM-CSF in Patients With Advanced Melanoma
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2015-11-23
Completion:
2033-06-30
Conditions
Stage III Cutaneous Melanoma AJCC v7
Stage IV Cutaneous Melanoma AJCC v6 and v7
Interventions
PROCEDURE
BIOLOGICAL
No Results Yet
24
Participants
Compassionate Use of Metreleptin in Previously Treated People With Generalized Lipodystrophy
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2014-10-09
Completion:
2027-07-31
Conditions
Lipodystrophy
Diabetes
Hyperlipidemia
Interventions
DRUG
No Results Yet
29
Participants
Compassionate Use of Metreleptin in Previously Treated People With Partial Lipodystrophy
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2014-10-14
Completion:
2027-07-31
Conditions
Diabetes
Lipodystrophy
Hyperlipidemia
Interventions
DRUG
No Results Yet
982
Participants
An Efficacy and Safety Study of Apalutamide (JNJ-56021927) in Combination With Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone in Participants With Chemotherapy-naive Metastatic Castration-resistant Prostate Cancer (mCRPC)
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2014-11-26
Completion:
2018-03-19
Conditions
Prostatic Neoplasms
Interventions
DRUG
70
Participants
HSCT for Patients With Fanconi Anemia Using Risk-Adjusted Chemotherapy
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2014-04-30
Completion:
2026-12-31
Conditions
Fanconi Anemia
Severe Marrow Failure
Myelodysplastic Syndrome (MDS)
Acute Myelogenous Leukemia (AML)
Interventions
DRUG
BIOLOGICAL
No Results Yet
300
Participants
Deep Brain Stimulation Therapy in Movement Disorders
Study Type:
INTERVENTIONAL
Last Updated:
2025-11-12
Start Date:
2014-04-02
Completion:
2030-12-01
Conditions
Parkinson's Disease
Interventions
DEVICE
No Results Yet
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