Clinical Trials

NCT05946213 | RECRUITING | PHASE3
1209 Participants

Testing Shorter Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With High Risk Prostate Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-12-14
Completion: 2036-03-31
Conditions
Prostate Adenocarcinoma Stage III Prostate Cancer AJCC v8 Stage IVA Prostate Cancer AJCC v8
Interventions
PROCEDURE RADIATION OTHER
No Results Yet
NCT05937776 | RECRUITING
20 Participants

Developing a New Metabolic Imaging Approach (aMRI) for Evaluating Neurological Disease in Patients With Gliomas

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2023-12-11
Completion: 2025-12-31
Conditions
Glioma
Interventions
OTHER PROCEDURE
No Results Yet
NCT05929937 | RECRUITING | PHASE4
904 Participants

No Opioids vs. Minimal Opioids Following Inguinal Hernia Repair

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-07-10
Completion: 2027-06-30
Conditions
Postoperative Pain Inguinal Hernia
Interventions
DRUG OTHER
No Results Yet
NCT05927532 | COMPLETED | NA
40 Participants

Argyle Safety Fistula Cannula With Anti-reflux Valve Clinical Study

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-03-10
Completion: 2024-12-15
Conditions
End Stage Renal Failure on Dialysis
Interventions
DEVICE
No Results Yet
NCT05923073 | RECRUITING | PHASE3
120 Participants

A Study of Guselkumab in Pediatric Participants With Moderately to Severely Active Crohn's Disease

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-03-13
Completion: 2027-10-27
Conditions
Crohn's Disease
Interventions
DRUG
No Results Yet
NCT05913908 | RECRUITING | NA
15 Participants

EFS of the DUO System for Tricuspid Regurgitation

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-08-13
Completion: 2025-12-31
Conditions
Tricuspid Regurgitation Tricuspid Valve Insufficiency Tricuspid Valve Disease Heart Valve Diseases
Interventions
DEVICE
No Results Yet
NCT05912517 | RECRUITING | PHASE3
120 Participants

A Study of Nipocalimab in Pregnancies at Risk for Severe Hemolytic Disease of the Fetus and Newborn (HDFN)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-12-20
Completion: 2027-08-05
Conditions
Hemolytic Disease of the Fetus and Newborn
Interventions
DRUG
No Results Yet
NCT05911997 | RECRUITING | PHASE1
60 Participants

MTC Versus FMT in for RCDI

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-01-08
Completion: 2026-07-25
Conditions
Clostridiodies Difficile Infections
Interventions
DRUG
No Results Yet
NCT05908734 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
71 Participants

A Study of Combination Therapy With Amivantamab and Cetrelimab in Participants With Metastatic Non-small Cell Lung Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-05-18
Completion: 2026-01-30
Conditions
Carcinoma, Non-Small-Cell Lung
Interventions
DRUG
No Results Yet
NCT05904080 | RECRUITING | PHASE2
50 Participants

Testing Nivolumab and Ipilimumab Immunotherapy With or Without the Targeted Drug Cabozantinib in Recurrent, Metastatic, or Incurable Nasopharyngeal Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-02-19
Completion: 2028-06-16
Conditions
Metastatic Nasopharyngeal Carcinoma Recurrent Nasopharyngeal Carcinoma Stage IV Nasopharyngeal Carcinoma AJCC v8
Interventions
PROCEDURE DRUG BIOLOGICAL
No Results Yet
NCT05902169 | ACTIVE_NOT_RECRUITING | PHASE3
560 Participants

Sonocloud-9 in Association With Carboplatin Versus Standard-of-Care Chemotherapies (CCNU or TMZ) in Recurrent GBM

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-01-29
Completion: 2028-01-28
Conditions
Glioblastoma Recurrent Glioblastoma GBM
Interventions
DEVICE DRUG
No Results Yet
NCT05899049 | ACTIVE_NOT_RECRUITING | PHASE3
249 Participants
NCT05898620 | RECRUITING | PHASE3
33 Participants

A Novel, Regulated Gene Therapy (NGN-401) Study for Females With Rett Syndrome

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-06-13
Completion: 2029-12-31
Conditions
Rett Syndrome
Interventions
GENETIC
No Results Yet
NCT05896839 | RECRUITING | PHASE1/PHASE2
16 Participants

Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-07-24
Completion: 2027-01-31
Conditions
Clinical Stage III Cutaneous Melanoma AJCC v8 Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8 Clinical Stage IV Cutaneous Melanoma AJCC v8 Clinical Stage IV Cutaneous Merkel Cell Carcinoma AJCC v8 Metastatic Basal Cell Carcinoma Metastatic Carcinoma in the Skin Metastatic Melanoma Metastatic Merkel Cell Carcinoma Metastatic Skin Squamous Cell Carcinoma Unresectable Basal Cell Carcinoma Unresectable Melanoma Unresectable Merkel Cell Carcinoma Unresectable Skin Squamous Cell Carcinoma
Interventions
PROCEDURE BIOLOGICAL DRUG
No Results Yet
NCT05893797 | COMPLETED | NA
36 Participants

A Study of LY8888AX in Participants Using a Connected Insulin Management Platform

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-10-05
Completion: 2024-09-16
Conditions
Type 1 Diabetes Type 2 Diabetes Type 2 Diabetes Treated With Insulin
Interventions
DRUG DEVICE
NCT05884398 | ACTIVE_NOT_RECRUITING | PHASE3
420 Participants

A Study of an Intermittent ADT Approach With Apalutamide Monotherapy in Participants With mCSPC

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-08-31
Completion: 2026-10-12
Conditions
Metastatic Castrate-sensitive Prostate Cancer
Interventions
DRUG
No Results Yet
NCT05877300 | RECRUITING | PHASE1
10 Participants

Safety and Feasibility Study of the CELLSPAN Esophageal Implant (CEI) in Patients Requiring Short Segment Esophageal Replacement

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-07-13
Completion: 2026-07-31
Conditions
Esophageal Diseases
Interventions
COMBINATION_PRODUCT
No Results Yet
NCT05876923 | RECRUITING | NA
70 Participants

The Effects of Exercise on Immune Phenotype of Indolent Non-Hodgkin Lymphoma and Chronic Lymphocytic Leukemia Patients

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-06-12
Completion: 2028-03-13
Conditions
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma Indolent Non-hodgkin Lymphoma
Interventions
PROCEDURE OTHER
No Results Yet
NCT05868330 | RECRUITING | PHASE4
56 Participants

Comparison of Interscalene Catheter to Single Injection Interscalene Blocks for Total Shoulder Arthroplasties

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-08-19
Completion: 2026-10-31
Conditions
Post Operative Pain Anesthesia Nerve Block Shoulder Osteoarthritis
Interventions
PROCEDURE
No Results Yet
NCT05860413 | COMPLETED | NA
57 Participants

Intermittent Fasting for the Treatment of Type 2 Diabetes Mellitus

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-01-24
Completion: 2025-05-20
Conditions
Type 2 Diabetes
Interventions
BEHAVIORAL
No Results Yet
NCT05848089 | COMPLETED | NA
41 Participants

Real-time Intervention for Suicide Risk Reduction

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-09-25
Completion: 2024-09-16
Conditions
Suicidal Ideation Suicide Attempt
Interventions
BEHAVIORAL
No Results Yet
NCT05843643 | RECRUITING | PHASE3
1000 Participants

Program to Assess Adverse Events and Change in Disease Activity of Oral Upadacitinib in Adult Participants With Moderate to Severe Systemic Lupus Erythematosus

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-07-19
Completion: 2026-12-31
Conditions
Systemic Lupus Erythematosus
Interventions
DRUG
No Results Yet
NCT05843253 | RECRUITING | PHASE2
120 Participants

Study of Ribociclib and Everolimus in HGG and DIPG or Ribociclib and Temozolomide in DHG, H3G34-mutant

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-08-22
Completion: 2029-08-31
Conditions
High Grade Glioma Diffuse Intrinsic Pontine Glioma Anaplastic Astrocytoma Glioblastoma Glioblastoma Multiforme Diffuse Midline Glioma, H3 K27M-Mutant Metastatic Brain Tumor WHO Grade III Glioma WHO Grade IV Glioma Diffuse Hemispheric Glioma, H3 G34-Mutant
Interventions
DRUG
No Results Yet
NCT05841030 | ACTIVE_NOT_RECRUITING
544 Participants

A Study in Participants With Major Depressive Disorder (MDD) With Anhedonia and Inadequate Response to Current Antidepressant Therapy Including a Selective Serotonin Reuptake Inhibitor (SSRI) or Serotonin Norepinephrine Reuptake Inhibitor (SNRI)

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2023-04-28
Completion: 2025-11-21
Conditions
Depressive Disorder, Major
Interventions
OTHER
No Results Yet
NCT05840159 | RECRUITING | PHASE4
664 Participants

A Study of Doxycycline to Treat Chlamydial Infection

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2024-01-19
Completion: 2026-02-28
Conditions
Chlamydial Infection
Interventions
DRUG OTHER
No Results Yet
NCT05839379 | RECRUITING
350 Participants

Targeted Pediatric High-Grade Glioma Therapy

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2024-08-02
Completion: 2029-08-28
Conditions
High Grade Glioma Diffuse Intrinsic Pontine Glioma Anaplastic Astrocytoma Glioblastoma Glioblastoma Multiforme Diffuse Midline Glioma, H3 K27M-Mutant Metastatic Brain Tumor WHO Grade III Glioma WHO Grade IV Glioma
No Results Yet
NCT05838742 | TERMINATED | PHASE2
314 Participants

A Dose-Finding Study to Evaluate the Efficacy and Safety of GSK3858279 in Adults With Knee Osteoarthritis (OA) Pain

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-09-13
Completion: 2024-08-12
Conditions
Pain Osteoarthritis, Knee
Interventions
DRUG
NCT05828589 | RECRUITING | PHASE1
112 Participants

A Study of BGB-21447, a Bcl-2 Inhibitor, in Mature B-Cell Malignancies

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-06-20
Completion: 2027-04-30
Conditions
Relapsed Non-Hodgkin Lymphoma Refractory Non-Hodgkin Lymphoma Relapsed Chronic Lymphocytic Leukemia Refractory Chronic Lymphocytic Leukemia Relapsed Follicular Lymphoma Relapsed Marginal Zone Lymphoma Relapse Diffuse Large B Cell Lymphoma Relapsed Small Lymphocytic Lymphoma Refractory Follicular Lymphoma Refractory Marginal Zone Lymphoma Refractory Small Lymphocytic Lymphoma Richter Transformation Refractory Diffuse Large B-cell Lymphoma Transformed Non-Hodgkin Lymphoma
Interventions
DRUG
No Results Yet
NCT05818683 | RECRUITING | PHASE1
185 Participants

A Study of JNJ-78278343 in Combination With Either JNJ-63723283 (Cetrelimab), Taxane Chemotherapy, or Androgen Receptor Pathway Inhibitors for Metastatic Prostate Cancer

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-04-26
Completion: 2026-06-30
Conditions
Metastatic Castration-resistant Prostate Neoplasms Metastatic Hormone-sensitive Prostate Cancer
Interventions
DRUG
No Results Yet
NCT05818540 | COMPLETED | NA
173 Participants

Sleep Apnea Study in Adults Using DreamPort-Eclipse and a Traditional Nasal Mask

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-04-17
Completion: 2023-12-29
Conditions
Obstructive Sleep Apnea
Interventions
DEVICE
NCT05811351 | ACTIVE_NOT_RECRUITING | PHASE2
305 Participants

A Study to Evaluate Intravitreal JNJ-81201887 (AAVCAGsCD59) Compared to Sham Procedure for the Treatment of Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-03-06
Completion: 2026-02-26
Conditions
Geographic Atrophy
Interventions
DRUG OTHER
No Results Yet
NCT05807139 | RECRUITING | PHASE1
20 Participants

Spironolactone in Alcohol Use Disorder (SAUD)

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-07-13
Completion: 2025-12-31
Conditions
Alcohol Use Disorder
Interventions
OTHER DRUG
No Results Yet
NCT05802615 | COMPLETED | NA
60 Participants

Protective Assets Reinforced With Integrated Care and TechnologY (PARITY) Feasibility Trial

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-04-06
Completion: 2025-08-06
Conditions
Maternal Health Blood Pressure
Interventions
BEHAVIORAL OTHER
No Results Yet
NCT05800405 | RECRUITING | EARLY_PHASE1
9 Participants

Evaluation of Bridging Radiation Therapy Before CAR T-Cell Infusion for the Treatment of Relapsed or Refractory Large B-Cell Lymphoma

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-07-20
Completion: 2026-01-13
Conditions
Recurrent Diffuse Large B-Cell Lymphoma Refractory Diffuse Large B-Cell Lymphoma
Interventions
PROCEDURE BIOLOGICAL RADIATION
No Results Yet
NCT05799105 | RECRUITING | PHASE4
122 Participants

OPEN Versus InTact Capsule Proton Pump Inhibitors for the Treatment of Marginal Ulcers

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-03-14
Completion: 2025-12-23
Conditions
Marginal Ulcer
Interventions
DRUG
No Results Yet
NCT05798117 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2
21 Participants

An Open-label, Study to Assess Safety, Efficacy and Cellular Kinetics of YTB323 in Severe, Refractory Systemic Lupus Erythematosus

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-02-28
Completion: 2026-09-09
Conditions
Systemic Lupus Erythematosus Lupus Nephritis
Interventions
DRUG
No Results Yet
NCT05797168 | RECRUITING | PHASE1/PHASE2
506 Participants

Phase I/IIa Study of AZD5335 as Monotherapy and Combination Therapy in Participants With Solid Tumors

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-06-05
Completion: 2028-01-06
Conditions
Ovarian Cancer Lung Adenocarcinoma Endometrial Cancer
Interventions
DRUG
No Results Yet
NCT05796375 | RECRUITING | NA
240 Participants

Replacing Invasive Cystoscopy With Urine Testing for Non-muscle Invasive Bladder Cancer Surveillance

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-11-17
Completion: 2028-11-30
Conditions
Non-muscle-invasive Bladder Cancer
Interventions
PROCEDURE DIAGNOSTIC_TEST
No Results Yet
NCT05794997 | COMPLETED
817337 Participants

Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM)- Propranolol/Carvedilol Versus Atenolol/Bisoprolol/Sotalol

Study Type: OBSERVATIONAL
Last Updated: 2025-11-10
Start Date: 2022-11-30
Completion: 2023-01-01
Conditions
Hypertension
Interventions
DRUG
NCT05789082 | RECRUITING | PHASE1/PHASE2
240 Participants

A Study Evaluating the Safety, Activity, and Pharmacokinetics of Divarasib in Combination With Other Anti-Cancer Therapies in Participants With Previously Untreated Advanced or Metastatic Non-Small Cell Lung Cancer With a KRAS G12C Mutation

Study Type: INTERVENTIONAL
Last Updated: 2025-11-10
Start Date: 2023-06-20
Completion: 2032-01-29
Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG
No Results Yet
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