Clinical Trials

NCT05419024 | RECRUITING | PHASE2

50 Participants

Imaging and Biopsy of People With HIV-1 Undergoing Analytic Treatment Interruption

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2023-01-09

Completion: 2026-08-01

Conditions

HIV

Interventions

OTHER

No Results Yet

NCT05411198 | RECRUITING | PHASE3

65 Participants

Study to Assess Change in Disease Activity and Adverse Events of Ab Externo Approach for Glaucoma Gel Stent (XEN45) Implantation In Participants Aged 45 Years or Older With Open-Angle Glaucoma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-07-22

Completion: 2026-01-31

Conditions

Open-Angle Glaucoma

Interventions

DEVICE

No Results Yet

NCT05408845 | RECRUITING | PHASE2

146 Participants

Testing the Use of Ado-Trastuzumab Emtansine Compared to the Usual Treatment (Chemotherapy With Docetaxel Plus Trastuzumab) or Trastuzumab Deruxtecan for Recurrent, Metastatic, or Unresectable HER2-Expressing Salivary Gland Cancers

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2023-03-03

Completion: 2028-07-31

Conditions

Metastatic Salivary Gland Carcinoma Recurrent Salivary Gland Carcinoma Stage III Major Salivary Gland Cancer AJCC v8 Stage IV Major Salivary Gland Cancer AJCC v8 Unresectable Salivary Gland Carcinoma

Interventions

PROCEDURE DRUG OTHER BIOLOGICAL

No Results Yet

NCT05397470 | TERMINATED | PHASE3

260 Participants

Efficacy and Safety of Losmapimod in Treating Participants With Facioscapulohumeral Muscular Dystrophy (FSHD) (REACH)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-06-16

Completion: 2024-11-19

Conditions

Facioscapulohumeral Muscular Dystrophy (FSHD)

Interventions

DRUG

Results Available

NCT05388669 | ACTIVE_NOT_RECRUITING | PHASE3

418 Participants

A Study of Lazertinib With Subcutaneous Amivantamab Compared With Intravenous Amivantamab in Participants With Epidermal Growth Factor Receptor (EGFR)-Mutated Advanced or Metastatic Non-small Cell Lung Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-08-05

Completion: 2024-01-03

Conditions

Advanced or Metastatic Non-small Cell Lung Cancer

Interventions

DRUG

No Results Yet

NCT05379634 | ACTIVE_NOT_RECRUITING | PHASE2

36 Participants

A Study of Nipocalimab in Participants With Active Idiopathic Inflammatory Myopathies

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-07-05

Completion: 2025-09-04

Conditions

Myositis

Interventions

DRUG OTHER

No Results Yet

NCT05379595 | RECRUITING | PHASE1/PHASE2

225 Participants

A Study of Amivantamab Monotherapy and in Addition to Standard-of-Care Chemotherapy in Participants With Advanced or Metastatic Colorectal Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-07-29

Completion: 2027-04-27

Conditions

Advanced or Metastatic Colorectal Cancer

Interventions

BIOLOGICAL

No Results Yet

NCT05371509 | COMPLETED | NA

43 Participants

Novel Myofunctional Water Bottle to Reduce OSA and Snoring Study

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2023-09-07

Completion: 2024-12-10

Conditions

Obstructive Sleep Apnea Snoring

Interventions

DEVICE OTHER

Results Available

NCT05359861 | COMPLETED | PHASE2

30 Participants

Trial of Atezolizumab and Bevacizumab With SRF388 or Placebo in Patients With Hepatocellular Carcinoma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-04-12

Completion: 2025-06-30

Conditions

Hepatocellular Carcinoma

Interventions

DRUG

No Results Yet

NCT05347095 | ACTIVE_NOT_RECRUITING | PHASE3

288 Participants

A Study of Guselkumab in Participants With Fistulizing, Perianal Crohn's Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-09-27

Completion: 2027-03-25

Conditions

Fistulizing Crohns Disease Perianal Crohns Disease

Interventions

DRUG

No Results Yet

NCT05339061 | RECRUITING | NA

40 Participants

Physician Modified Endograft For Complex Aortic Aneurysm Repair

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2023-03-01

Completion: 2025-12-31

Conditions

Complex Abdominal Aortic Aneurysm Juxtarenal Aortic Aneurysm Pararenal Aortic Aneurysm Thoracoabdominal Aortic Aneurysm

Interventions

DEVICE

No Results Yet

NCT05338775 | ACTIVE_NOT_RECRUITING | PHASE1

74 Participants

A Study of Talquetamab and Teclistamab Each in Combination With a Programmed Cell Death Receptor-1 (PD-1) Inhibitor for the Treatment of Participants With Relapsed or Refractory Multiple Myeloma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-05-25

Completion: 2025-05-22

Conditions

Relapsed/ Refractory Multiple Myeloma

Interventions

DRUG

No Results Yet

NCT05327686 | RECRUITING | PHASE2

240 Participants

Testing the Addition of Stereotactic Radiation Therapy With Immune Therapy for the Treatment of Patients With Unresectable or Metastatic Renal Cell Cancer, SAMURAI Trial

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2023-02-01

Completion: 2028-06-15

Conditions

Metastatic Renal Cell Carcinoma Stage III Renal Cell Cancer AJCC v8 Stage IV Renal Cell Cancer AJCC v8 Unresectable Renal Cell Carcinoma

Interventions

BIOLOGICAL DRUG PROCEDURE RADIATION

No Results Yet

NCT05327114 | RECRUITING | PHASE2/PHASE3

201 Participants

Efficacy and Safety Study of Nipocalimab for Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-09-23

Completion: 2027-05-14

Conditions

Polyradiculoneuropathy, Chronic Inflammatory Demyelinating

Interventions

DRUG

No Results Yet

NCT05319730 | RECRUITING | PHASE1/PHASE2

230 Participants

A Study to Evaluate Investigational Agents With or Without Pembrolizumab (MK-3475) in Participants With Advanced Esophageal Cancer Previously Exposed to Programmed Cell Death 1 Protein (PD-1)/ Programmed Cell Death Ligand 1 (PD-L1) Treatment (MK-3475-06B)

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2023-05-16

Completion: 2026-11-07

Conditions

Esophageal Squamous Cell Carcinoma

Interventions

DRUG BIOLOGICAL

No Results Yet

NCT05316311 | RECRUITING | NA

194 Participants

A Study of Implantation of CRENEOUS ENTERPRISE 2 Intracranial Stent in Participants With Severe Symptomatic Intracranial Atherosclerotic Stenosis

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-05-24

Completion: 2026-02-10

Conditions

Intracranial Atherosclerosis

Interventions

DEVICE

No Results Yet

NCT05303519 | RECRUITING | PHASE2

125 Participants

Safusidenib Phase 2 Study in IDH1 Mutant Glioma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2023-06-05

Completion: 2027-12-01

Conditions

Glioma Astrocytoma, Grade IV IDH1-mutant Glioma Astrocytoma, IDH-Mutant, Grade 3 Astrocytoma, IDH-Mutant, Grade 4

Interventions

DRUG

No Results Yet

NCT05296304 | RECRUITING | PHASE1

20 Participants

A Study of Bexarotene Combined With Radiotherapy in People With Mycosis Fungoides

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-03-16

Completion: 2026-03-31

Conditions

Cutaneous T-cell Lymphoma

Interventions

DRUG RADIATION

No Results Yet

NCT05286801 | ACTIVE_NOT_RECRUITING | PHASE1/PHASE2

86 Participants

Tiragolumab and Atezolizumab for the Treatment of Relapsed or Refractory SMARCB1 or SMARCA4 Deficient Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-11-17

Completion: 2030-03-31

Conditions

Atypical Teratoid/Rhabdoid Tumor Epithelioid Sarcoma Kidney Medullary Carcinoma Malignant Solid Neoplasm Poorly Differentiated Chordoma Recurrent Atypical Teratoid/Rhabdoid Tumor Recurrent Chordoma Recurrent Epithelioid Sarcoma Recurrent Kidney Medullary Carcinoma Recurrent Malignant Solid Neoplasm Recurrent Rhabdoid Tumor Refractory Atypical Teratoid/Rhabdoid Tumor Refractory Chordoma Refractory Epithelioid Sarcoma Refractory Kidney Medullary Carcinoma Refractory Malignant Solid Neoplasm Refractory Rhabdoid Tumor Rhabdoid Tumor

Interventions

BIOLOGICAL PROCEDURE OTHER

No Results Yet

NCT05278234 | ACTIVE_NOT_RECRUITING | NA

414 Participants

STEPS: An Efficacy Trial of a Chronic Pain Self-Management Program for Older Adults

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-11-29

Completion: 2026-04-01

Conditions

Chronic Pain

Interventions

BEHAVIORAL

No Results Yet

NCT05277051 | RECRUITING | PHASE1

158 Participants

First-Time-in-Human Study of GSK4381562 in Participants With Advanced Solid Tumors

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-03-22

Completion: 2027-08-31

Conditions

Neoplasms

Interventions

DRUG

No Results Yet

NCT05275868 | TERMINATED | PHASE1

41 Participants

Study of MGY825 in Patients With Advanced Non-small Cell Lung Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-10-05

Completion: 2025-10-13

Conditions

Non-small Cell Lung Cancer

Interventions

DRUG

No Results Yet

NCT05272631 | ACTIVE_NOT_RECRUITING

250 Participants

Depuy Synthes Lower Extremity Shaft Nail Registry

Study Type: OBSERVATIONAL

Last Updated: 2025-11-10

Start Date: 2022-05-04

Completion: 2025-12-31

Conditions

Femoral Fractures Tibial Fractures

Interventions

DEVICE

No Results Yet

NCT05265273 | RECRUITING | PHASE2/PHASE3

12 Participants

A Study of Nipocalimab in Children Aged 2 to Less Than 18 Years With Generalized Myasthenia Gravis

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-07-20

Completion: 2026-06-26

Conditions

Myasthenia Gravis

Interventions

DRUG

No Results Yet

NCT05256641 | RECRUITING | PHASE1/PHASE2

24 Participants

Acalabrutinib Maintenance for the Treatment of Patients With Large B-cell Lymphoma

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2023-01-23

Completion: 2026-01-31

Conditions

Diffuse Large B-Cell Lymphoma High-grade B-cell Lymphoma Transformed Lymphoma Secondary Central Nervous System Lymphoma

Interventions

DRUG

No Results Yet

NCT05250973 | ACTIVE_NOT_RECRUITING | PHASE2

151 Participants

A Study of Daratumumab-Based Therapies in Participants With Amyloid Light Chain (AL) Amyloidosis

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-03-01

Completion: 2025-05-30

Conditions

Amyloidosis

Interventions

DRUG

No Results Yet

NCT05250284 | RECRUITING

400 Participants

The Intersection of Oncology Care and Worker Well-Being

Study Type: OBSERVATIONAL

Last Updated: 2025-11-10

Start Date: 2022-04-04

Completion: 2026-05-31

Conditions

Solid Tumor

Interventions

BEHAVIORAL

No Results Yet

NCT05247866 | COMPLETED | PHASE4

21 Participants

Efficacy of Dupilumab on Facilitated Food Introduction in Eosinophilic Esophagitis

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-06-16

Completion: 2025-01-21

Conditions

Eosinophilic Esophagitis

Interventions

DIETARY_SUPPLEMENT DRUG

Results Available

NCT05246839 | TERMINATED

1823 Participants

Informed Choice - Compass

Study Type: OBSERVATIONAL

Last Updated: 2025-11-10

Start Date: 2022-04-28

Completion: 2025-01-31

Conditions

Colorectal Cancer

Interventions

BEHAVIORAL

No Results Yet

NCT05245786 | RECRUITING | EARLY_PHASE1

15 Participants

An Investigational Scan (64Cu-Labeled M5A Antibody) in Combination With SOC Chemotherapy and Radiotherapy in Locally Advanced Rectal Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-08-31

Completion: 2026-11-12

Conditions

Locally Advanced Rectal Carcinoma Stage III Rectal Cancer AJCC v8 Stage IIIA Rectal Cancer AJCC v8 Stage IIIB Rectal Cancer AJCC v8 Stage IIIC Rectal Cancer AJCC v8

Interventions

BIOLOGICAL PROCEDURE

No Results Yet

NCT05245500 | RECRUITING | PHASE1

336 Participants

Phase 1 Study of MRTX1719 in Solid Tumors With MTAP Deletion

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-06-09

Completion: 2027-12-10

Conditions

Mesothelioma Non Small Cell Lung Cancer Malignant Peripheral Nerve Sheath Tumors Solid Tumor Pancreatic Adenocarcinoma Advanced Solid Tumor

Interventions

DRUG

No Results Yet

NCT05242484 | ACTIVE_NOT_RECRUITING | PHASE2

577 Participants

A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Ulcerative Colitis

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-09-19

Completion: 2025-05-15

Conditions

Colitis, Ulcerative

Interventions

BIOLOGICAL DRUG

No Results Yet

NCT05242471 | ACTIVE_NOT_RECRUITING | PHASE2

703 Participants

A Study of Combination Therapy With Guselkumab and Golimumab in Participants With Moderately to Severely Active Crohn's Disease

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-07-22

Completion: 2025-05-23

Conditions

Crohn's Disease

Interventions

BIOLOGICAL DRUG

No Results Yet

NCT05237128 | COMPLETED | NA

182 Participants

The Lifestyle Education About Nutrition for Diabetes (Legend) Study

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-03-22

Completion: 2025-10-01

Conditions

Type 2 Diabetes

Interventions

BEHAVIORAL

No Results Yet

NCT05235425 | ACTIVE_NOT_RECRUITING | NA

300 Participants

The Lifestyle Education About Prediabetes (Leap) Study

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-03-20

Completion: 2025-11-15

Conditions

PreDiabetes

Interventions

BEHAVIORAL

No Results Yet

NCT05232110 | APPROVED_FOR_MARKETING

Compassionate Use of Pozelimab

Study Type: EXPANDED_ACCESS

Last Updated: 2025-11-10

Conditions

CD55-deficient Protein-losing Enteropathy

Interventions

DRUG

No Results Yet

NCT05223803 | RECRUITING | PHASE2

122 Participants

TERPS Trial for de Novo Oligometastic Prostate Cancer

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2022-10-18

Completion: 2026-07-31

Conditions

Prostate Cancer Oligometastatic Disease

Interventions

RADIATION DRUG

No Results Yet

NCT05223036 | SUSPENDED | PHASE2

80 Participants

Testing Obeticholic Acid for Familial Adenomatous Polyposis

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2023-01-19

Completion: 2029-01-31

Conditions

Attenuated Familial Adenomatous Polyposis Colorectal Carcinoma Duodenal Carcinoma Familial Adenomatous Polyposis

Interventions

PROCEDURE BIOLOGICAL DRUG OTHER

No Results Yet

NCT05220501 | COMPLETED | NA

804 Participants

Optimization of Prostate Biopsy - Micro-Ultrasound Versus MRI

Study Type: INTERVENTIONAL

Last Updated: 2025-11-10

Start Date: 2021-12-15

Completion: 2024-09-06

Conditions

Prostate Cancer

Interventions

DIAGNOSTIC_TEST

Results Available

NCT05213572 | RECRUITING

200 Participants

Observational Study to Deeply Phenotype Major Organs in Sickle Cell Disease After Curative Therapies

Study Type: OBSERVATIONAL

Last Updated: 2025-11-10

Start Date: 2022-03-24

Completion: 2035-06-01

Conditions

Mortality in Sickle Cell Sickle Cell Cardiopulmonary Complications Sickle Cell Organ Damage Sickle Cell Life Expectancy and Risk Factors for Early Death Sickle Cell Lung Disease and Sudden Death

No Results Yet