IMMUNOREA - Immunological and Inflammatory Determinants Associated With the Prognosis of Intensive Care Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

540 participants

Study Classification

OBSERVATIONAL

Study Start Date

2026-01-31

Study Completion Date

2031-02-28

Brief Summary

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This is a prospective observational physiopathological study aimed at evaluating the immunological and inflammatory determinants associated with the prognosis of patients admitted to intensive care units (ICU). The study will establish multidimensional models predicting one-year survival and the occurrence of nosocomial infections.

Patients admitted to ICU undergo routine biological sampling. In addition to these, minimal supplementary samples will be collected for immunological and inflammatory biomarker analysis at admission, day 1, day 4, day 8, ICU discharge or day 28, and at 12 months. Additional samples may be taken during clinically significant events (nosocomial infections, complications).

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Detailed Description

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Conditions

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Critical Illness Intensive Care Patients Critical Illness Requiring Intensive Care - Sepsis Critical Illness Requiring Intensive Care - Acute Brain Injury Critical Illness Requiring Intensive Care - Major Surgery Critical Illness Requiring Intensive Care - Polytrauma

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Age ≥ 18 years
* Admission to ICU within 24 hours

Exclusion Criteria

* Moribund patient (ECOG=4)
* Legal protection (guardianship/curatorship)
* Uninsured patients
* Pre-existing immunosuppression (active/recent cancer, hematologic disease, autoimmune disease, organ transplant, HIV)
* Pregnant or breastfeeding women
* Participation in another interventional trial
* Patients under AME

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No